Inhibition of neuroinflammation by cinnamon and its main components

Ho, Su-Chen; Chang, Ku-Shang; Chang, Pei-Wen

doi:10.1016/j.foodchem.2012.12.020

Cited by 88 publications

(74 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…But there was no earlier study studying the effects of cinnamon polyphenol on the NF- κ B p65 in the liver with which to compare this study. Nevertheless, in a previous study, it was shown that cinnamon-based treatment induced inhibition of NF- κ B and neuroinflammation and supported our present findings [52]. …”

Section: Discussionsupporting

confidence: 93%

Cinnamon Polyphenol Extract Inhibits Hyperlipidemia and Inflammation by Modulation of Transcription Factors in High‐Fat Diet‐Fed Rats

Tuzcu

Orhan

Şahin

et al. 2017

Oxidative Medicine and Cellular Longevity

115

View full text Add to dashboard Cite

We evaluated the effects of cinnamon polyphenol extract on hepatic transcription factors expressions including SREBP-1c and LXR-α in rats fed high fat diet (HFD). Twenty-eight Wistar rats were allocated into four groups: (i) normal control: animals fed with normal chow; (ii) cinnamon: animals supplemented with cinnamon polyphenol; (iii) HFD: animals fed a high-fat diet; and (iv) HFD + cinnamon: animals fed a high-fat diet and treated with cinnamon polyphenol. Obesity was linked to hyperglycemia, hyperlipidemia, and oxidative stress as imitated by elevated serum glucose, lipid profile, and serum and liver malondialdehyde (MDA) concentrations. Cinnamon polyphenol decreased body weight, visceral fat, liver weight and serum glucose and insulin concentrations, liver antioxidant enzymes, and lipid profile (P < 0.05) and reduced serum and liver MDA concentration compared to HFD rats (P < 0.05). Cinnamon polyphenol also suppressed the hepatic SREBP-1c, LXR-α, ACLY, FAS, and NF-κB p65 expressions and enhanced the PPAR-α, IRS-1, Nrf2, and HO-1 expressions in the HFD rat livers (P < 0.05). In conclusion, cinnamon polyphenol reduces the hyperlipidemia, inflammation, and oxidative stress through activating transcription factors and antioxidative defense signaling pathway in HFD rat liver.

show abstract

Section: Discussionsupporting

confidence: 93%

Cinnamon Polyphenol Extract Inhibits Hyperlipidemia and Inflammation by Modulation of Transcription Factors in High‐Fat Diet‐Fed Rats

Tuzcu

Orhan

Şahin

et al. 2017

Oxidative Medicine and Cellular Longevity

115

View full text Add to dashboard Cite

show abstract

“…Cinnamaldehyde is a diterpene found in considerable quantities in the stem bark of Cinnamomum cassia (He et al ., ) and exhibits anti‐inflammatory action in vitro (Reddy et al ., ; Youn et al ., ; Ho et al ., ). Cinnamaldehyde also protected against cardiac ischaemia injury by inhibiting inflammation in vivo (Hwa et al ., ) and a recent study showed that cinnamaldehyde provided neuroprotection in inflammation‐mediated neurodegenerative diseases (Pyo et al ., ).…”

Section: Resultsmentioning

confidence: 97%

“…In our study, a certain number of factors related to inflammatory response, such as inflammatory cytokines (IL‐1β and TNF‐α), chemokines (CCL2) and adhesion molecules (ELAM‐1), were induced by ischaemia and inhibited by cinnamaldehyde, indicating that the neuroprotective efficacy of cinnamaldehyde could be attributed, at least in part, to its anti‐inflammatory activities. This is in agreement with previous reports of the anti‐inflammatory effects of cinnamaldehyde, in vitro and in vivo (Ho et al ., ; Pyo et al ., ).…”

Section: Resultsmentioning

confidence: 99%

“…(A)-(C) Immunohistochemical staining for TLR4, TRAF6 and NF-κB in different groups at 24 h after cerebral ischaemia (400 × magnification). Results shown are the means ± SEM, n = 3 * P < 0.05, versus Cinnamaldehyde is a diterpene found in considerable quantities in the stem bark of Cinnamomum cassia (He et al, 2005) and exhibits anti-inflammatory action in vitro (Reddy et al, 2004;Youn et al, 2008;Ho et al, 2013). Cinnamaldehyde also protected against cardiac ischaemia injury by inhibiting inflammation in vivo (Hwa et al, 2012) and a recent study showed that cinnamaldehyde provided neuroprotection in inflammation-mediated neurodegenerative diseases (Pyo et al, 2013).…”

Section: Figurementioning

confidence: 98%

See 1 more Smart Citation

Cinnamaldehyde inhibits inflammation and brain damage in a mouse model of permanent cerebral ischaemia

Zhao

Zhang

Dong

et al. 2015

British J Pharmacology

View full text Add to dashboard Cite

BACKGROUND AND PURPOSERecent findings suggest the importance of inflammation in the pathogenesis of cerebral ischaemia and its potential as a therapeutic target. Cinnamaldehyde is a diterpene with a wide range of anti-inflammatory effects thus may be advantageous in the treatment of cerebral ischaemia. The present study examined the potential therapeutic effects of cinnamaldehyde on cerebral ischaemia using a mouse model with permanent middle cerebral artery occlusion. EXPERIMENTAL APPROACHMale CD-1 mice, which had the middle cerebral artery occluded, were treated (i.p.) with cinnamaldehyde. Neuroprotection by cinnamaldehyde was analysed by evaluating neurological deficit scores, brain oedema and infarct volume. Expressionsof signal transduction molecules and inflammatory mediators were measured by Western blotting, qRT-PCR and immunohistochemical staining. Activation of NF-κB was assessed by Western blotting, immunohistochemistry and immunofluorescence. KEY RESULTSCinnamaldehyde reduced the neurological deficit scores, brain oedema and infarct volume. Cinnamaldehyde suppressed the activation of signal transduction molecules including toll-like receptor 4, tumour necrosis receptor-associated factor 6 and NF-κB, attenuated the increased levels of TNF-α, IL-1β, CCL2 and endothelial-leukocyte adhesion molecule-1 and ultimately reduced leukocyte infiltration into the ischaemic brain areas after cerebral ischaemia. CONCLUSIONS AND IMPLICATIONSCinnamaldehyde protects against cerebral ischaemia injury by inhibiting inflammation, partly mediated by reducing the expression of toll-like receptor 4, tumour necrosis receptor-associated factor 6 and the nuclear translocation of NF-κB. Our findings suggest that cinnamaldehyde may serve as a new candidate for further development as a treatment for stroke. AbbreviationsBBB, blood brain barrier; ELAM-1, endothelial leukocyte adhesion molecule-1; IHC, immunohistochemical staining; IRAK, IL-1 receptor-associated kinase; MAPKs, mitogen-activated protein kinases; MPO, myeloperoxidase; pMCAO, permanent middle cerebral artery occlusion; qRT-PCR, quantitative real-time polymerase chain reaction; rCBF, relative regional cerebral blood flow; TRAF6, tumour necrosis factor receptor-associated factor 6; TTC, 2,3,5-triphenyltetrazolium chloride BJP British Journal of Pharmacology

show abstract

“…C. verum belongs to the genus Cinnamomum, which includes about 250 species of plants distributed worldwide, especially in parts of Africa and Asia [13]. C. verum has several medicinal properties, such as anti-inflammatory, hypoglycemic, antibacterial, antioxidant, spasmolytic, antidiarrheal, antifungal, antitumor, analgesic, gastroprotective, anticancer, and anthelmintic ones [14,19,20]. Interestingly, recent studies have documented the antimalarial efficacy of C. verum extract [21,22].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Characterization and Chemotherapeutic Potential of Cinnamomum verum Extracts on the Multiplication of Protozoan Parasites In Vitro and In Vivo

et al. 2020

View full text Add to dashboard Cite

Cinnamomum verum is a commonly used herbal plant that has several documented properties against various diseases. The existing study evaluated the inhibitory effect of acetonic extract of C. verum (AECV) and ethyl acetate extract of C. verum (EAECV) against piroplasm parasites in vitro and in vivo. The drug-exposure viability assay was tested on Madin-Darby bovine kidney (MDBK), mouse embryonic fibroblast (NIH/3T3) and human foreskin fibroblast (HFF) cells. Qualitative phytochemical estimation revealed that AECV and EAECV containing multiple bioactive constituents namely alkaloids, tannins, saponins, terpenoids and remarkable amounts of polyphenols and flavonoids. AECV and EAECV inhibited B. bovis, B. bigemina, B. divergens, B. caballi, and T. equi multiplication at half-maximal inhibitory concentrations (IC50) of 23.1 ± 1.4, 56.6 ± 9.1, 33.4 ± 2.1, 40.3 ± 7.5, 18.8 ± 1.6 µg/mL, and 40.1 ± 8.5, 55.6 ± 1.1, 45.7 ± 1.9, 50.2 ± 6.2, and 61.5 ± 5.2 µg/mL, respectively. In the cytotoxicity assay, AECV and EAECV affected the viability of MDBK, NIH/3T3 and HFF cells with half-maximum effective concentrations (EC50) of 440 ± 10.6, 816 ± 12.7 and 914 ± 12.2 µg/mL and 376 ± 11.2, 610 ± 7.7 and 790 ± 12.4 µg/mL, respectively. The in vivo experiment showed that AECV and EAECV were effective against B. microti in mice at 150 mg/kg. These results showed that C. verum extracts are potential antipiroplasm drugs after further studies in some clinical cases.

show abstract

Inhibition of neuroinflammation by cinnamon and its main components

Cited by 88 publications

References 31 publications

Cinnamon Polyphenol Extract Inhibits Hyperlipidemia and Inflammation by Modulation of Transcription Factors in High‐Fat Diet‐Fed Rats

Cinnamon Polyphenol Extract Inhibits Hyperlipidemia and Inflammation by Modulation of Transcription Factors in High‐Fat Diet‐Fed Rats

Cinnamaldehyde inhibits inflammation and brain damage in a mouse model of permanent cerebral ischaemia

Phytochemical Characterization and Chemotherapeutic Potential of Cinnamomum verum Extracts on the Multiplication of Protozoan Parasites In Vitro and In Vivo

Contact Info

Product

Resources

About