Inhibition of Oxidative Modification of Low Density Lipoprotein by Antioxidants

Niki, Etsuo; Noguchi, Noriko; Gotoh, Naohiro

doi:10.3177/jnsv.39.supplement_s1

Cited by 17 publications

(5 citation statements)

References 18 publications

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“…α‐tocopherol is the most abundant and active antioxidant in LDL [ 32]. Greatly elevated α‐tocopherol levels in LDL may increase its resistance to copper induced oxidation [ 26].…”

Section: Discussionmentioning

confidence: 99%

Combined oestrogen–progestogen replacement therapy does not inhibit low‐density lipoprotein oxidation in postmenopausal women

Wen¹,

Doyle²,

Norris

et al. 1999

Brit J Clinical Pharma

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Aims The use of oestrogen containing hormone replacement therapy (HRT) is related to a significantly reduced atherosclerotic cardiovascular risk in postmenopausal women. Oestrogen is thought to be antioxidant and may inhibit low-density lipoprotein (LDL) oxidation in vitro. We investigated the effect of combined oestrogen and progestogen HRT on LDL oxidation in postmenopausal women. Methods Eighteen healthy women were given oestrogen/progestogen, and the susceptibility of LDL to oxidation was measured as the level of autoantibody to oxidative modified LDL and the production of conjugated dienes during copperdependent oxidation after 3 and 6 months HRT. The levels of vitamin E, the major antioxidant in LDL, were also measured. Results After HRT, the anti-oxidatively modified LDL antibody level remained unchanged [1.58±0.16, 0.10 (−0.10, 0.26), and 0.08 (−0.09, 0.19), mean±s.d. at baseline, and mean change with 95% confidence intervals for differences at 3 and 6 months, respectively, P >0.05] as did the production of conjugated dienes when determined as lag phase [51.2±7.

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“…α‐tocopherol is the most abundant and active antioxidant in LDL [ 32]. Greatly elevated α‐tocopherol levels in LDL may increase its resistance to copper induced oxidation [ 26].…”

Section: Discussionmentioning

confidence: 99%

Combined oestrogen–progestogen replacement therapy does not inhibit low‐density lipoprotein oxidation in postmenopausal women

Wen¹,

Doyle²,

Norris

et al. 1999

Brit J Clinical Pharma

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“…Eventually, CoQ exerts an antioxidant role by preventing oxidative damage in the low-density lipoproteins (LDLs), which is essential for the protection against cardiovascular diseases [ 101 , 102 ]. Takahashi and colleagues show that an LDL-associated CoQ-reducing mechanism exists at the external surface of the plasma membrane in HepG2 cells [ 103 ].…”

Section: Coenzymeq10mentioning

confidence: 99%

CoQ10 and Resveratrol Effects to Ameliorate Aged-Related Mitochondrial Dysfunctions

Gherardi

Corbioli²,

Ruzza³

et al. 2022

Nutrients

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Mitochondria participate in the maintenance of cellular homeostasis. Firstly, mitochondria regulate energy metabolism through oxidative phosphorylation. In addition, they are involved in cell fate decisions by activating the apoptotic intrinsic pathway. Finally, they work as intracellular signaling hubs as a result of their tight regulation of ion and metabolite concentrations and other critical signaling molecules such as ROS. Aging is a multifactorial process triggered by impairments in different cellular components. Among the various molecular pathways involved, mitochondria are key regulators of longevity. Indeed, mitochondrial deterioration is a critical signature of the aging process. In this scenario, we will focus specifically on the age-related decrease in CoQ levels, an essential component of the electron transport chain (ETC) and an antioxidant, and how CoQ supplementation could benefit the aging process. Generally, any treatment that improves and sustains mitochondrial functionality is a good candidate to counteract age-related mitochondrial dysfunctions. In recent years, heightened attention has been given to natural compounds that modulate mitochondrial function. One of the most famous is resveratrol due to its ability to increase mitochondrial biogenesis and work as an antioxidant agent. This review will discuss recent clinical trials and meta-analyses based on resveratrol and CoQ supplementation, focusing on how these compounds could improve mitochondrial functionality during aging.

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“…CoQ also plays an key antioxidant role in the prevention of oxidative damage in plasma cholesterol lipoproteins, essentially in low-density lipoproteins (LDLs) [ 89 ]. This role has been essentially considered in the prevention of, and protection against, cardiovascular diseases and atherogenesis [ 4 , 90 ].…”

Section: Coq As Metabolic Integrative Factor For Cellular Homeostasismentioning

confidence: 99%

Coenzyme Q at the Hinge of Health and Metabolic Diseases

et al. 2021

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Coenzyme Q is a unique lipidic molecule highly conserved in evolution and essential to maintaining aerobic metabolism. It is endogenously synthesized in all cells by a very complex pathway involving a group of nuclear genes that share high homology among species. This pathway is tightly regulated at transcription and translation, but also by environment and energy requirements. Here, we review how coenzyme Q reacts within mitochondria to promote ATP synthesis and also integrates a plethora of metabolic pathways and regulates mitochondrial oxidative stress. Coenzyme Q is also located in all cellular membranes and plasma lipoproteins in which it exerts antioxidant function, and its reaction with different extramitochondrial oxidoreductases contributes to regulate the cellular redox homeostasis and cytosolic oxidative stress, providing a key factor in controlling various apoptosis mechanisms. Coenzyme Q levels can be decreased in humans by defects in the biosynthesis pathway or by mitochondrial or cytosolic dysfunctions, leading to a highly heterogeneous group of mitochondrial diseases included in the coenzyme Q deficiency syndrome. We also review the importance of coenzyme Q levels and its reactions involved in aging and age-associated metabolic disorders, and how the strategy of its supplementation has had benefits for combating these diseases and for physical performance in aging.

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Inhibition of Oxidative Modification of Low Density Lipoprotein by Antioxidants

Cited by 17 publications

References 18 publications

Combined oestrogen–progestogen replacement therapy does not inhibit low‐density lipoprotein oxidation in postmenopausal women

Combined oestrogen–progestogen replacement therapy does not inhibit low‐density lipoprotein oxidation in postmenopausal women

CoQ10 and Resveratrol Effects to Ameliorate Aged-Related Mitochondrial Dysfunctions

Coenzyme Q at the Hinge of Health and Metabolic Diseases

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