2013
DOI: 10.1016/j.bbagen.2013.03.013
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Inhibition of TNF-α, and NF-κB and JNK pathways accounts for the prophylactic action of the natural phenolic, allylpyrocatechol against indomethacin gastropathy

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Cited by 31 publications
(30 citation statements)
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“…This anti-inflammatory effect of sEHI was expected on the basis of previous observations (Schmelzer et al, 2005;Zhang et al, 2012;Kodani and Hammock, 2015). OME was also reported to decrease the levels of MPO and TNF-a in indomethacin-induced ulcers (Chatterjee et al, 2012;Yadav et al, 2013). In our study, pretreatment with OME decreased the level of MPO and TNF-a significantly, consistent with OME having significant anti-inflammatory activity in addition to inhibiting proton pumps (Fig.…”
Section: Resultssupporting
confidence: 78%
“…This anti-inflammatory effect of sEHI was expected on the basis of previous observations (Schmelzer et al, 2005;Zhang et al, 2012;Kodani and Hammock, 2015). OME was also reported to decrease the levels of MPO and TNF-a in indomethacin-induced ulcers (Chatterjee et al, 2012;Yadav et al, 2013). In our study, pretreatment with OME decreased the level of MPO and TNF-a significantly, consistent with OME having significant anti-inflammatory activity in addition to inhibiting proton pumps (Fig.…”
Section: Resultssupporting
confidence: 78%
“…O mecanismo de indução de úlcera é mediado por espécies reativas de oxigênio (ROS) (Oyagi et al, 2010;Yadav et al, 2013). No extrato etanólico de P. alnifolia foi identificado a presença de rutina (Andrade et al, 2012), flavonoide com elevada capacidade antioxidante (Yang et al, 2008).…”
Section: Resultado E Discussãounclassified
“…)-induced acute stomach ulceration in mice. Moreover, the protocols of IND-mediated ulceration in mice, and its healing by several anti-ulcer agents have also been extensively studied by our group [23,24]. Hence the present study was carried out under the same experimental conditions.…”
Section: Discussionmentioning
confidence: 96%
“…Group I mice served as normal control, while ulceration in the groups II-V mice was induced by IND (18 mg kg − 1 , p. o., single dose) dissolved in distilled water and suspended in the vehicle, gum acacia (2%). The dose of IND and the treatment regime (drug doses and period of treatment) were standardized in our earlier studies [9,23,24]. The mice of groups I and III (referred to as control) were given the daily oral dose of vehicle (gum acacia in distilled water, 0.2 ml).…”
Section: Experimental Protocol For Ulceration and Biochemical Studiesmentioning
confidence: 99%