Inhibition of Transplantable and Spontaneous Murine Tumours by the M-P Virus

Molomut, Norman; Padnos, Morton

doi:10.1038/208948a0

Cited by 25 publications

(6 citation statements)

References 2 publications

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“…It has been known for many years that acute virus infections inhibit tumor development [32]. This has not been surprising, since IFN has long been known to have an anti tumor effect [11], and acute virus infections, of course, often induce high levels of IFN.…”

Section: Evidence For An Nk Cell Role In Virus Infectionsmentioning

confidence: 96%

Activation and role of natural killer cells in virus infections

Biron

Welsh

1982

Med Microbiol Immunol

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Section: Evidence For An Nk Cell Role In Virus Infectionsmentioning

confidence: 96%

Activation and role of natural killer cells in virus infections

Biron

Welsh

1982

Med Microbiol Immunol

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“…Since the r3LCMV vector and the tumor do not share any antigen, the antitumoral effect that we report is considered bystander. Earlier studies by Lang and others have shown that infection of tumor-bearing mice with chronic strains of LCMV can improve tumor control (27)(28)(29)(30). However, safety concerns of using live LCMV have deemed this approach not translatable to humans.…”

Section: Discussionmentioning

confidence: 99%

Replication-attenuated r3LCMV vectors potentiate tumor control via IFN-I

Chung,

Awakoaiye,

Dangi

et al. 2023

Preprint

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SummaryViral vectors are being used for the treatment of cancer. Yet their efficacy varies among tumors and their use poses challenges in immunosuppressed patients, underscoring the need for alternatives. We report striking antitumoral effects by a nonlytic viral vector based on attenuated lymphocytic choriomeningitis virus (r3LCMV). We show in multiple tumor models that injection of tumor-bearing mice with this novel vector results in improved tumor control and survival. Importantly, r3LCMV also improved tumor control in immunodeficient Rag1-/- mice. Single cell RNA-Seq analyses, antibody blockade experiments, and KO models revealed a critical role for host IFN-I in the antitumoral efficacy of r3LCMV vectors. Collectively, these data demonstrate potent antitumoral effects by a replication-attenuated LCMV vector and unveil mechanisms underlying its antitumoral efficacy.

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“…Viral infections inhibit the growth of implanted tumor cells in animal models (36), and tumor remission is sometimes seen after virus infection in humans (37). Other studies have shown that vaccination of humans with mixtures of virus and tumor cells (viral oncolysates) can induce tumor-specific immunity (38).…”

Section: Discussionmentioning

confidence: 99%