Inhibition of Vitamin D Receptor Translocation by Cigarette Smoking Extracts

Uh, Soo Taek; Koo, So-My; Kim, Yang Ki; Kim, Ki Up; Park, Sung Woo; Kim, Dojin; Kim, Yong Hoon; Park, Choon-Sik

doi:10.4046/trd.2012.73.5.258

Cited by 30 publications

(24 citation statements)

References 22 publications

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“…(P=0.105) Similar to Syal SK study which is an Indian study. 21 This variation may be due to ethnic differences as observed by Sragg R. 25 As cigarette smoking inhibits Vitamin D induced translocation of VDR from the nucleus to the cell membrane efficiency of Vitamin D decreases as observed by Uh ST et al 16 Though Brot C observed deleterious effect of smoking on Vitamin D level, our study did not show any significant correlation between Smoking and Vitamin D level. 26 Significant link between family history (an important nonmodifiable risk factor) of CAD and Vitamin D level was observed by Entezari-Maleki, Taher.…”

Section: Discussioncontrasting

confidence: 53%

“…14 Ford ES demonstrated inverse relationship of vitamin D level with MS. 15 Smoking causes decrease in Nitric Oxide (NO) availability and inhibits translocation of vitamin D receptor from the nucleus to the cell membrane resulting in VDD. 16 Cardio vascular diseases (CVD) specially CAD has shown a steep rise in last few decades in India due to rising trend of obesity, high blood pressure, dyslipidemia, change in food habits ,sedentary life style. New emerging risk factors like VDD homocysteine level and inflammation are under recent investigations.…”

Section: Introductionmentioning

confidence: 99%

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The correlation of cardiovascular risk factors and angiographic findings with serum vitamin D levels in patients undergoing coronary angiography

Tripathy¹,

Dhal²,

Pattnaik³

et al. 2017

Int J Basic Clin Pharmacol

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INTRODUCTIONVDD is now a pandemic cutting across age groups, ruralurban divide and developing or developed countries. . Vit-D level <20ng/ml i.e. Vit-D deficiency (VDD) in 68, 20-30ng/ml i.e. Vit-D insufficiency (VDI) in 22 and >30ng/ml (normal) in 10. VDD was profound in 51-60 and 61-70 years age groups. Statistical correlation of VDD was not significant with conventional risk factors, but statistically significant correlation of VDD was observed with dyslipidemia and CAG findings in our study. Conclusions: Like earlier studies we observed significant correlation of Vit-D levels with CAD. Though dyslipidemia was significantly correlated with VDD, correlation of other conventional risk factors like age, sex, HTN, DM, smoking and family history was not found. We conclude from this study presence of significant association of VDD with severe CAD. DVD and TVD by CAG were common with low Vit-D levels.

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Section: Discussioncontrasting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

The correlation of cardiovascular risk factors and angiographic findings with serum vitamin D levels in patients undergoing coronary angiography

Tripathy¹,

Dhal²,

Pattnaik³

et al. 2017

Int J Basic Clin Pharmacol

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“…The actions of the vitamin D hormone [1,25‐dihydroxyvitamin D 3 (1,25(OH) 2 D 3 )] are mediated by the nuclear VDR, which when activated, causes transcription of several genes which regulate calcium metabolism and expression of cytokines and key antimicrobial peptides (Pike & Meyer, ). Cigarette smoking extracts interfere with the binding of vitamin D to its receptors and inhibit VDR translocation from the nucleus to the cytoplasm with subsequent impairment in the intracellular signaling pathway (Uh et al, ).…”

Section: Discussionmentioning

confidence: 99%

Cigarette smoking reduces the efficacy of intralesional vitamin D in the treatment of warts

El-Taweel

Salem

Allam³

2019

Dermatologic Therapy

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Cigarette smoking may decrease serum levels of vitamin D and reduce its efficacy. We aimed to evaluate the safety and efficacy of intralesional vitamin D in the treatment of warts and to investigate the effect of smoking on its efficacy in these cases. The study included 20 patients with verruca vulgaris and deep palmoplantar warts. The wart to be injected was cleaned by alcohol and then injected with 0.1 mL of prilocaine (20 mg/mL). 0.2 mL of vitamin D3 (7.5 mg/mL) solution was slowly injected into the base of each wart. The maximum total amount of vitamin D3 injected into a patient in one session was 7.5 mg. The injection was done at 4 weeks interval until clearance or for a maximum of two sessions. Clinical and dermoscopic follow‐up of the treated and distant warts was carried out. Forty percent of the treated lesions showed complete clearance and the rate of distant wart response was 17.65%. Among different demographic and clinical variables in the studied patients, smoking and older age seemed to decrease the therapeutic response Intralesional vitamin D is effective in the treatment of warts, however, smoking and aging may reduce its efficacy.

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“…One study has shown that exposing cells in culture to cigarette smoke inhibits vitamin D induced translocation of the nuclear VDR [73], however this appears to be the only evidence that cigarette smoke has a direct impact on vitamin D pathways. While acknowledging that work in this area is limited the potential upregulation of VDR in response to an insult has important implications when considering the validity of measuring 25(OH)D alone when examining disease associations.…”

Section: Chronic Obstructive Pulmonary Disease (Copd)mentioning

confidence: 99%

Vitamin D Deficiency and the Lung: Disease Initiator or Disease Modifier?

Foong

Zosky

2013

Nutrients

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Vitamin D deficiency is a global public health problem and has been associated with an increased incidence and severity of many diseases including diseases of the respiratory system. These associations have largely been demonstrated epidemiologically and have formed the basis of the justification for a large number of clinical supplementation trials with a view to improving disease outcomes. However, the trials that have been completed to date and the ongoing experimental studies that have attempted to demonstrate a mechanistic link between vitamin D deficiency and lung disease have been disappointing. This observation raises many questions regarding whether vitamin D deficiency is truly associated with disease pathogenesis, is only important in the exacerbation of disease or is simply an indirect biomarker of other disease mechanisms? In this review, we will briefly summarize our current understanding of the role of vitamin D in these processes with a focus on lung disease.

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Inhibition of Vitamin D Receptor Translocation by Cigarette Smoking Extracts

Cited by 30 publications

References 22 publications

The correlation of cardiovascular risk factors and angiographic findings with serum vitamin D levels in patients undergoing coronary angiography

The correlation of cardiovascular risk factors and angiographic findings with serum vitamin D levels in patients undergoing coronary angiography

Cigarette smoking reduces the efficacy of intralesional vitamin D in the treatment of warts

Vitamin D Deficiency and the Lung: Disease Initiator or Disease Modifier?

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