Inhibitors ofα-glucosidase andα-amylase fromCyperus rotundus

Tran, Hong Hanh Thi; Nguyen, Minh; Le, Hoang Tram; Nguyen, Thi Luyen; Pham, Thanh Binh; Chau, Van Minh; Nguyễn, Hoài Nam; Dat, Nguyen Tien

doi:10.3109/13880209.2013.814692

Cited by 66 publications

(24 citation statements)

References 30 publications

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“…The porcine pancreas α -amylase (A3176, Sigma-Aldrich) enzyme inhibitory activity was carried out according to the standard method with minor modifications [20–22]. The substrate was prepared by boiling 100 mg potato starch in 5 mL phosphate buffer (pH 7.0) for 5 min and then cooling to room temperature.…”

Section: Methodsmentioning

confidence: 99%

α-Amylase and α-Glucosidase Inhibitory Activities of Chemical Constituents from Wedelia chinensis (Osbeck.) Merr. Leaves

Thao

Binh

Luyen

et al. 2018

Journal of Analytical Methods in Chemistry

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As part of an ongoing search for new natural products from medicinal plants to treat type 2 diabetes, two new compounds, a megastigmane sesquiterpenoid sulfonic acid (1) and a new cyclohexylethanoid derivative (2), and seven related known compounds (3–9) were isolated from the leaves of Wedelia chinensis (Osbeck.) Merr. The structures of the compounds were conducted via interpretation of their spectroscopic data (1D and 2D NMR, IR, and MS), and the absolute configurations of compound 1 were determined by the modified Mosher's method. The MeOH extract of W. chinensis was found to inhibit α-amylase and α-glucosidase inhibitory activities as well as by the compounds isolated from this extract. Furthermore, compound 7 showed the strongest effect with IC50 values of 112.8 ± 15.1 μg/mL (against α-amylase) and 785.9 ± 12.7 μg/mL (against α-glucosidase). Compounds 1, 8, and 9 showed moderate α-amylase and α-glucosidase inhibitory effects. Other compounds showed weak or did not show any effect on both enzymes. The results suggested that the antidiabetic properties from the leaves of W. chinensis are not simply a result of each isolated compound but are due to other components such as the accessibility of polyphenolic groups to α-amylase and α-glucosidase activities.

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Section: Methodsmentioning

confidence: 99%

α-Amylase and α-Glucosidase Inhibitory Activities of Chemical Constituents from Wedelia chinensis (Osbeck.) Merr. Leaves

Thao

Binh

Luyen

et al. 2018

Journal of Analytical Methods in Chemistry

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“…Furthermore, constituent 1 has β-secretase and Aβ inhibitory activities ( Jeon et al ., 2007 ; Rivière et al ., 2010 ; Richard et al ., 2011 ), but the direct neuroprotective effects of constituent 1 were demonstrated for the first time in the present study. Several studies have reported that constituent 2 exhibits anti-oxidative, anti-diabetic, and anti-photoaging activities, as well as vasorelaxing effects ( Kobayashi et al ., 2006 ; Sano et al ., 2011 ; Maruki-Uchida et al ., 2013 ; Tran et al ., 2014 ), while no study on the neuroprotective effects of constituent 2 has been reported. However, further investigation is necessary to confirm these effects in animal models and to determine the molecular mechanisms underlying the neuroprotection of constituents 1 and 2.…”

Section: Discussionmentioning

confidence: 99%

Identification of Neuroactive Constituents of the Ethyl Acetate Fraction from Cyperi Rhizoma Using Bioactivity-Guided Fractionation

Sim

Choi

et al. 2016

Biomolecules & Therapeutics

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Cyperi Rhizoma (CR), the rhizome of Cyperus rotundus L., exhibits neuroprotective effects in in vitro and in vivo models of neuronal diseases. Nevertheless, no study has aimed at finding the neuroactive constituent(s) of CR. In this study, we identified active compounds in a CR extract (CRE) using bioactivity-guided fractionation. We first compared the anti-oxidative and neuroprotective activities of four fractions and the CRE total extract. Only the ethyl acetate (EA) fraction revealed strong activity, and further isolation from the bioactive EA fraction yielded nine constituents: scirpusin A (1), scirpusin B (2), luteolin (3), 6′-acetyl-3,6-diferuloylsucrose (4), 4′,6′ diacetyl-3,6-diferuloylsucrose (5), p-coumaric acid (6), ferulic acid (7), pinellic acid (8), and fulgidic acid (9). The activities of constituents 1–9 were assessed in terms of anti-oxidative, neuroprotective, anti-inflammatory, and anti-amyloid-β activities. Constituents 1, 2, and 3 exhibited strong activities; constituents 1 and 2 were characterized for the first time in this study. These results provide evidence for the value of CRE as a source of multi-functional neuroprotectants, and constituents 1 and 2 may represent new candidates for further development in therapeutic use against neurodegenerative diseases.

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“…This comparison is made with the anti-diabetic compound acarbose. The concentration of the test compound is 200 and 500mg/kg (Tran et al, 2014).…”

Section: Cyperus Rotundus (Scariosus) (Musta )mentioning

confidence: 99%

Studying the Anti-Diabetic Basis of Ayurvedic Formulations –Avipattikara Churna And Triphala Churna

K¹,

Nagarajan²,

Kumar

2020

ijrps

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Diabetes mellitus (DM), belongs to the class of metabolic diseases having the primary symptom associated with this disease is high sugar levels in the blood for an extended period. It can be categorized to the world's major diseases considering that affects the high population on the earth and presents two main types I and II.The prevalence of diabetes for all age-groups world-wide was estimated to be 2.8% in 2000 and 4.4% in 2030. Diabetes complications include possible blindness, amputation of a lower limb, renal failure, and cardiac arrest or stroke. There are twenty types of Pramehas (Kaphaja-10 Pittaja-6, and Vataja-4) have been mentioned in the Ayurveda. ‘Prameha’ and ‘Diabetes’ are synonymous. Diabetes is one of the ‘Prameha’ which consists of two words, ‘Pra’ meaning abundant, and ‘Meha' meaning 'passing of large quantity of Urine. Incidentally, the term diabetes has been derived from the Greek term 'Diabainein' to mean 'to cross through a siphon' meaning the continuous free flow of water and applied to mean the elimination of large quantity of Urine. Thus the terms ‘Prameha’ and ‘Diabetes’ carry similar meaning. This review summarizes the two Ayurvedic formulations for both types of DM, which are mentioned in the Ayurvedic Formulary of India. Till now, various kinds of synthetic and herbal formulations were made, and many are more frequently used to achieve desirable treatment. Patients prefer oral anti-diabetic medications since they are more comfortable to be administered, and for this reason, researchers focus their studies in this direction. This review aimed to explore the possibility of anti-diabetic treatment from herbal sources well mentioned in Ayurvedic Formulary of India that is Avipattikara Churna, Triphala Churna.Triphala Churna

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Inhibitors ofα-glucosidase andα-amylase fromCyperus rotundus

Cited by 66 publications

References 30 publications

α-Amylase and α-Glucosidase Inhibitory Activities of Chemical Constituents from Wedelia chinensis (Osbeck.) Merr. Leaves

α-Amylase and α-Glucosidase Inhibitory Activities of Chemical Constituents from Wedelia chinensis (Osbeck.) Merr. Leaves

Identification of Neuroactive Constituents of the Ethyl Acetate Fraction from Cyperi Rhizoma Using Bioactivity-Guided Fractionation

Studying the Anti-Diabetic Basis of Ayurvedic Formulations –Avipattikara Churna And Triphala Churna

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