Inhibitors of biotin biosynthesis as potential herbicides

N-Carbamate α-aminoalkyl-p-tolylsulfones—convenient substrates in the nitro-Mannich synthesis of secondary N-carbamate protected syn-2-amino-1-nitroalkanephosphonates

“…24 Similarly, the mixture of trans-and cis-4g (cleavage of N-Cbz group was accomplished using ammonium formate/PdeC system 25 ) afforded the mixture of the appropriate trans-and cisimidazolidine-2-thiones 5a (trans/cis¼16/84) in 23% yield.…”

Triazolyl phenyl disulfides: 8-Amino-7-oxononanoate synthase inhibitors as potential herbicides

“…Biotin biosynthesis is understood in detail in Therefore, inhibition of the enzymes involved in the biotin biosynthesis pathway can cause irreparable damage to plants; for this reason, such enzymes can be useful targets for the rational design of inhibitors in the hopes of finding new herbicides [4,5].…”

“…Plants, microorganisms, and some fungi bio-synthesize their own biotin, while animals necessarily require trace amounts of the vitamin in their diet. Therefore, inhibition of the enzymes involved in the biotin biosynthesis pathway can cause irreparable damage to plants but be non-toxic to mammals; for this reason, such enzymes can be useful targets for the rational design of inhibitors in the hopes of finding new herbicides [4,5]. The validation of one potential herbicide target, 8-amino-7-oxononanoate synthase (AONS), was performed in vitro and in vivo with lead chemical triphenyltin acetate [6]; a natural compound, plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), was reported as a potential AONS inhibiting herbicide [7].…”

7-Keto-8-Aminopelagonic Acid Synthase as a Potential Herbicide Target

“…Plants, micro-organisms, and some fungi biosynthesize their own biotin, while animals necessarily require trace amounts of the vitamin in their diet. Therefore, inhibition of the enzymes involved in the biotin biosynthesis pathway can cause irreparable damage to plants, and for this reason, such enzymes can be useful targets for the rational design of inhibitors in the hopes of finding new herbicides (Webster et al, 2000;Nudelman et al, 2004). The aim of our investigation is to confirm that a particular enzyme chosen is indeed essential for a plant growth, and to validate the successful inhibition of the enzyme can lead …”