Inhibitory activity of traditional plants against Mycobacterium smegmatis and their action on Filamenting temperature sensitive mutant Z (FtsZ)—A cell division protein

Ravindran, Radhika; Chakrapani, Gayathri Devi; Mitra, Kartik; Doble, Mukesh

doi:10.1371/journal.pone.0232482

Cited by 13 publications

(3 citation statements)

References 56 publications

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“…Different concentrations of D‐pinitol (100, 250, 500, 750, and 1,000 µg/ml in water) were prepared and standard calibration curve was obtained to concentration D‐pinitol concentration in MPT extract (1 mg/ml). 5mM of H 2 SO 4 was used as an isocratic mobile phase at a flow rate of 0.6 ml/min and maintained at 50°C (Ravindran et al., 2020).…”

Section: Methodsmentioning

confidence: 99%

Polyphenol‐rich Indian ginger cultivars ameliorate GLUT4 activity in C2C12 cells, inhibit diabetes‐related enzymes and LPS‐induced inflammation: An in vitro study

et al. 2021

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Diabetes is a chronic metabolic disorder that results in distorted insulin signaling and microvascular complications. Current antidiabetic drugs possess harmful long term side effects, necessitating the need for alternate or compliment therapy with lesser issues. Medicinal plants such as ginger have been reported to possess several beneficial activities including antidiabetic activity. The antidiabetic efficacy of microwave-assisted polyphenolic extracts of Indian ginger cultivars from Odisha (MPO) and Tamil Nadu (MPT) is reported here. MPT and MPO showed insulin stimulated glucose uptake of 1.74 ± 0.25 and 1.47 ± 0.15 fold at 6.25 µg/ml of concentrations in C2C12 cells respectively when compared to control. MPT possessed α-amylase, α-glucosidase inhibitory and anti-glycation properties. It also showed DPPH radical scavenging activity (7.69 ± 0.001%), inhibited LPS-induced nitric oxide production (1.06 ± 0.004 fold) than the latter and increased the GLUT4 protein expression by 1.4 fold. Major active compounds such as shogaol and gingerol derivatives, curcumene, zingiberone were identified through GC-ESI/MS analysis and D-pinitol (cyclitol) was identified through HPLC analysis in this variety. This is the first paper to report the presence of an antidiabetic compound, D-pinitol, in the ginger variety. Polyphenol rich, biologically potent ginger extracts can be a good food and nutraceutical supplement to address diabetes and related complications. Practical applications Ginger is a native spice of South Asian Countries including India. Ginger extracts possess several medicinal properties such as anti-inflammatory, antidiabetic and antioxidant activities. It is used to treat nausea, vomiting and commonly used as a food flavouring agent and dietary food supplement. Our study shows the antidiabetic, anti-glycation and antioxidant efficacy of polyphenol rich Indian ginger cultivars grown in different geographical regions. Variations in the biological activities between the MPT and MPO ginger variety was observed. Different environmental conditions and their corresponding metabolite accumulation can be correlated with

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Section: Methodsmentioning

confidence: 99%

Polyphenol‐rich Indian ginger cultivars ameliorate GLUT4 activity in C2C12 cells, inhibit diabetes‐related enzymes and LPS‐induced inflammation: An in vitro study

et al. 2021

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“…(+)-Pinitol is the inositol methyl ether derivative, which can be found in more than 20 plant sources, and its highest content is in carob pods, at 5.5% [ 22 ]. The biological properties of (+)-pinitol have also been extensively studied, including anti-Alzheimer, antiaging, antibacterial, anticancer, antidepressant, antidiabetic, antifibrotic, antihyperlipidemic, and anti-inflammatory activities [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Alzheimer Potential of a New (+)-Pinitol Glycoside Isolated from Tamarindus indica Pulp: In Vivo and In Silico Evaluations

Mohamed¹,

Elmaidomy

Alaaeldin

et al. 2023

Metabolites

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Tamarindus indica Linn (tamarind, F. Leguminosae) is one of the most widely consumed edible fruits in the world. Phytochemical investigation of tamarind pulp n-butanol fraction yielded one new (+)-pinitol glycoside compound 1 (25% w/w), and 1D, 2D NMR, and HRESIMS investigation were used to confirm the new compound’s structure. (+)-Pinitol glycoside showed anti-Alzheimer potential that was confirmed in prophylactic and treatment groups by decreasing time for the T-maze test; decreased TAO, brain and serum AChE, MDA, tau protein levels, and β amyloid peptide protein levels; and increasing GPX, SOD levels, and in vivo regression of the neurodegenerative features of Alzheimer’s dementia in an aluminum-intoxicated rat model. The reported molecular targets for human Alzheimer’s disease were then used in a network pharmacology investigation to examine their complex interactions and identify the key targets in the disease pathogenesis. An in silico-based analysis (molecular docking, binding free energy calculation (ΔGBinding), and molecular dynamics simulation) was performed to identify the potential targets for compound 1. The findings of this study may lead to the development of dietary supplements for the treatment of Alzheimer’s disease.

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“…D-Pinitol (DP) is a methylated derivative of D-chiral-inositol, mainly from Ceratonia siliqua L [1]. Many biological properties of DP have been reported, including anti-diabetes, insulin regulation [2], antioxidant [3], antibacterial [4], treatment of polycystic ovary syndrome (PCOS) [5], antidepressant [6], hepatoprotective [7], and lipid-lowering [8]. DP can bind to PTPN22 receptor through Arg59, Tyr60, Leu106 and Lys138 to produce anti-in ammatory effect [9].…”

Section: Introductionmentioning

confidence: 99%

D-Pinitol extends antioxidant activity and longevity of Caenorhabditis elegans via insulin-like signaling pathway

Shi,

Liu,

et al. 2023

Preprint

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D-Pinitol is a cyclic polyol mainly derived from pinaceae and legume. It has the functions of regulating blood glucose balance, anti-inflammation and cardiovascular protection. D-Pinitol is a 3-methoxy analogue of D-chiral-inositol. In our previous study, we found that D-chiral-inositol could prolong the lifespan of Caenorcaditis elegans. D-Pinitol and D-chiral-inositol are commonly used in the treatment of diabetes and polycystic ovary syndrome. We therefore proceeded to investigate the anti-aging effect of D-Pinitol in Caenorhabditis elegans. Our findings demonstrate that D-Pinitol significantly extends the lifespan of Caenorhabditis elegans by 25.41%, enhances body bend frequency, and reduces lipofuscin accumulation. Moreover, it effectively delays neurodegenerative disease development in this model organism. Mechanistically, D-Pinitol promotes gene expression related to insulin-like signaling pathway in Caenorhabditis elegans while also reducing malondialdehyde levels and increasing total antioxidant capacity as well as superoxide dismutase and catalase activities. Consequently, our results indicate that through activation of the insulin-like signaling pathway, D-Pinitol improves both antioxidant capacity and lifespan in Caenorhabditis elegans—a testament to its remarkable antioxidative properties—thus highlighting the significance for further research on this compound.

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Inhibitory activity of traditional plants against Mycobacterium smegmatis and their action on Filamenting temperature sensitive mutant Z (FtsZ)—A cell division protein

Cited by 13 publications

References 56 publications

Polyphenol‐rich Indian ginger cultivars ameliorate GLUT4 activity in C2C12 cells, inhibit diabetes‐related enzymes and LPS‐induced inflammation: An in vitro study

Polyphenol‐rich Indian ginger cultivars ameliorate GLUT4 activity in C2C12 cells, inhibit diabetes‐related enzymes and LPS‐induced inflammation: An in vitro study

Anti-Alzheimer Potential of a New (+)-Pinitol Glycoside Isolated from Tamarindus indica Pulp: In Vivo and In Silico Evaluations

D-Pinitol extends antioxidant activity and longevity of Caenorhabditis elegans via insulin-like signaling pathway

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