Inhibitory Effect of Baicalein, a Flavonoid in Scutellaria Root, on Eotaxin Production by Human Dermal Fibroblasts

Nakajima, Toshiharu; Imanishi, Masako; Yamamoto, Kazuhiko; Cyong, Jong‐Chol; Hirai, Koichi

doi:10.1055/s-2001-11532

Cited by 60 publications

(39 citation statements)

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“…Baicalein and wogonin were shown to inhibit histamine release from rat mast cell in vitro with IC 50 of 52.1 M and 40.0 M, respectively (Kubo et al, 1984b). Another activity of baicalein, oroxylin A, and baicalin (in diminishing order of potency) associated with inflammation is in vitro inhibition of eotaxin production at 10 g/mL (Nakajima et al, 2001). Eotaxin acts to increase inflammation by recruiting eosinophils to allergic inflammatory sites such as the bronchi in asthma.…”

Section: Animal and In Vitro Studiesmentioning

confidence: 97%

Skullcap Scutellaria lateriflora L.: An American nervine

Upton¹,

DAyu²

2012

Journal of Herbal Medicine

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Section: Animal and In Vitro Studiesmentioning

confidence: 97%

Skullcap Scutellaria lateriflora L.: An American nervine

Upton¹,

DAyu²

2012

Journal of Herbal Medicine

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“…Baicalin inhibited the induction of IL-1b, IL-6, TNF-a , IFN-g, monocyte chemotactic protein-1, macrophage inflammatory protein (MIP)-1a , and MIP-1b at protein as well as at RNA levels from human blood monocytes treated with staphylococcal enterotoxin (67). In human dermal fibroblasts induced by IL-4 plus TNF-a, baicalein > oroxylin A > baicalin > skullcapflavone II inhibited eotaxin production (68).…”

Section: Effects On the Expression Of Inos And Cox-2mentioning

confidence: 99%

Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms

et al. 2004

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Abstract. Plant flavonoids show anti-inflammatory activity in vitro and in vivo. Although not fully understood, several action mechanisms are proposed to explain in vivo anti-inflammatory action. One of the important mechanisms is an inhibition of eicosanoid generating enzymes including phospholipase A 2 , cyclooxygenases, and lipoxygenases, thereby reducing the concentrations of prostanoids and leukotrienes. Recent studies have also shown that certain flavonoids, especially flavone derivatives, express their anti-inflammatory activity at least in part by modulation of proinflammatory gene expression such as cyclooxygenase-2, inducible nitric oxide synthase, and several pivotal cytokines. Due to these unique action mechanisms and significant in vivo activity, flavonoids are considered to be reasonable candidates for new anti-inflammatory drugs. To clearly establish the therapeutic value in inflammatory disorders, in vivo anti-inflammatory activity, and action mechanism of varieties of flavonoids need to be further elucidated. This review summarizes the effect of flavonoids on eicosanoid and nitric oxide generating enzymes and the effect on expression of proinflammatory genes. In vivo anti-inflammatory activity is also discussed. As natural modulators of proinflammatory gene expression, certain flavonoids have a potential for new anti-inflammatory agents.

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“…It is also reported in Oroxylum indicum or Indian trumpet flower. It has been reported to present anti-inflammatory [1], anti-HIV [2], anticancer [3][4][5][6], free radical scavenging and antioxidant effects [7,8], and also has been widely used in traditional Chinese medicine for a long time [9]. It can also chelate with some metal cations, including copper(II), cobalt(II), nickel(II), and zinc(II), to form stable complex with antibacterial and scavenging superoxide radical properties [10,11].…”

Section: Introductionmentioning

confidence: 99%