Inhibitory Effect of Cycloartenol Ferulate, a Component of Rice Bran, on Tumor Promotion in Two-Stage Carcinogenesis in Mouse Skin.

Studies on the nutraceuticals composition of wheat derived oils wheat bran oil and wheat germ oil

“…An oil rich in unsaturated fatty acids and good amount of minor components is expected to have number of beneficial health effects (Hu et al 1998). Some of the nutraceuticals of minor components in the oil are unique such as steryl ferulates (known as oryzanol in rice bran oil) which have number of biological activities viz., reducing serum cholesterol levels (Wilson et al 2007), inhibiting tumoroigenesis (Yasukawa et al 1998), anti-diabetic properties (Myoung et al 2011) and others. Some of the nutrients like carotenoids (β-carotene, pro vitamin A), tocopherols (vitamin E), cannot be synthesized de novo and hence have to be supplemented exogenously through foods.…”

Isolation of Campesteryl Ferulate and Epi-Campesteryl Ferulate, Two Components of γ-Oryzanol from Rice Bran

“…[1][2][3][4][5][6][7][8][9][10][11][12][13] -Oryzanol has been discussed in relation to a wide range of biological activities, including its effects on lipid metabolism, antioxidant activity, and ultraviolet absorptivity. Recently, -oryzanol has attracted much interest in view of its anti-inflammatory effects 14,15) and action against type-2 diabetes, 16) but it is unclear which components are important to these bioactivities.…”

“…[4][5][6][7][8][9][10][11][12][13] Recently, we developed novel process for efficient crystallization of 2 after removal of 1 by selective epoxidation of -oryzanol with m-chloroperbenzoic acid. 17) Other important components oforyzanol, such as 24-methylcholesteryl ferulate (3) and -sitosteryl ferulate (4) at more than 5% content were isolated by HPLC.…”

“…17) Other important components oforyzanol, such as 24-methylcholesteryl ferulate (3) and -sitosteryl ferulate (4) at more than 5% content were isolated by HPLC. [7][8][9][10][11][12][13] Five minor components have been isolated by HPLC: cycloartanyl ferulate by Rogers et al, 8) cyclobranyl ferulate by Norton et al, 9) stigmasteryl ferulate by Xu et al, 11) and 24-methylenecholesteryl ferulate and cycloeucalenyl ferulate by Akihisa et al 12) In 1998, Yasukawa et al found that compound 3 was a isomeric mixture at the 24 position (3:7 ratio), and they confirmed that compound 3 was constituted of campesteryl ferulate (3a) and epi-campesteryl ferulate (3b) by hydrolysis and subsequent acylation. 10) But the isolation of 3a and 3b have not been reported, except for assignment of the major parts of the 1 H-NMR spectrum of each component.…”

Stabilized rice bran extract: Acute and 28-day repeated dose oral toxicity with in vitro mutagenicity and genotoxicity study

“…Nonmutagenicity of rice bran oil was demonstrated using the bacterial reverse mutation Ames mutagenicity assay (Polasa and Rukmini, 1987). Other in vivo long-term toxicity studies evidenced the non-carcinogenic properties of the bran oil active constituents as γ-oryzanol and ferulic acid derivatives in rats and mice (Tamagawa et al, 1992;Yasukawa et al, 1998). Lack of toxicity testing of heat stabilized rice bran as well as its alcohol extract amplifies the need for further toxicological studies in order to determine its safety.…”