Inhibitory effect of garlic extract on oral bacteria

Bakri, I.; Douglas, C. W. I.

doi:10.1016/j.archoralbio.2004.12.002

Cited by 244 publications

(168 citation statements)

References 31 publications

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“…With the rise of bacterial resistance to antibiotics, there is need to search for other antimicrobial agents for treatment and control of oral infections. Garlic which is known to have antibacterial antiviral, anti-brotozoal and antifungal activity (Tariq Abdullah1987).It has an inhibitory effect against gram+ve and gram-ve bacteria in oral cavity (Elnima et al 1983), (Groppo 2002) inhibition of streptococcus mutans(,Bakri 2005) in study of the inhibitory effect on putative periodontal pathogens and (Fanni et al 2007) in study of inhibition of multidrug-resistant strain of streptococcus mutans,so in the present study ,which is the first study in Sudan, we confirmed the marked growth inhibition activity of garlic( grows in northern Sudan) against P. gingivalis which has been described before (Bakri 2005). Aqueous extract(concentration 16.5%) at serial dilution of 100%,, 50%, 25%,12.5% and 10% showed activity .…”

Section: Result:-supporting

confidence: 77%

Isolation of Actinobacillus Actinomycetumcomitans (Aggregobacter) Andporphyromonas Gingivalis From Sudanese Aggressive Periodontitis Patients and Testing Inhibitory Effect of Garlic Extract Compared to Chlorhexidine Digluconate 0.2%.

Mohamed.¹

2017

IJAR

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Section: Result:-supporting

confidence: 77%

Isolation of Actinobacillus Actinomycetumcomitans (Aggregobacter) Andporphyromonas Gingivalis From Sudanese Aggressive Periodontitis Patients and Testing Inhibitory Effect of Garlic Extract Compared to Chlorhexidine Digluconate 0.2%.

Mohamed.¹

2017

IJAR

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“…In fact there is an overwhelming number of studies on the biological activities of plants and their natural product derivatives (8)(9)(10). Essential oils and their derivatives are one such example (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of the essential oil from Lippia sidoides, carvacrol and thymol against oral pathogens

Botelho

Nogueira

Bastos

et al. 2007

Braz J Med Biol Res

348

222

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Dental caries and periodontal disease are associated with oral pathogens. Several plant derivatives have been evaluated with respect to their antimicrobial effects against such pathogenic microorganisms. Lippia sidoides Cham (Verbenaceae), popularly known as "Alecrimpimenta" is a typical shrub commonly found in the Northeast of Brazil. Many plant species belonging to the genus Lippia yield very fragrant essential oils of potential economic value which are used by the industry for the commercial production of perfumes, creams, lotions, and deodorants. Since the leaves of L. sidoides are also extensively used in popular medicine for the treatment of skin wounds and cuts, the objective of the present study was to evaluate the composition and antimicrobial activity of L. sidoides essential oil. The essential oil was obtained by hydro-distillation and analyzed by GC-MS. Twelve compounds were characterized, having as major constituents thymol (56.7%) and carvacrol (16.7%). The antimicrobial activity of the oil and the major components was tested against cariogenic bacterial species of the genus Streptococcus as well as Candida albicans using the broth dilution and disk diffusion assays. The essential oil and its major components thymol and carvacrol exhibited potent antimicrobial activity against the organisms tested with minimum inhibitory concentrations ranging from 0.625 to 10.0 mg/mL. The most sensitive microorganisms were C. albicans and Streptococcus mutans. The essential oil of L. sidoides and its major components exert promising antimicrobial effects against oral pathogens and suggest its likely usefulness to combat oral microbial growth.

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“…The garlic clove extract was prepared as described by Bakri and Douglas [5], with slight modifications. Fresh cloves were separated and peeled and then 10 g was weighed and crushed using a mortar and pestle.…”

Section: Preparation Of Garlic Clove Extractmentioning

confidence: 99%

In Vitro Antibacterial Mechanism of Action of Crude Garlic (Allium sativum) Clove Extract on Selected Probiotic Bifidobacterium Species as Revealed by SEM, TEM, and SDS-PAGE Analysis

Booyens

Labuschagne

Thantsha

2013

Probiotics & Antimicro. Prot.

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There has been much research on the effects of garlic (Allium sativum) on numerous pathogens, but very few, if any, studies on its effect on beneficial, probiotic bifidobacteria. We have recently shown that garlic exhibits antibacterial activity against bifidobacteria. The mechanism by which garlic kills bifidobacteria is yet to be elucidated. This study sought to determine the mechanism of action of garlic clove extract on selected Bifidobacterium species using scanning and transmission electron microscopy and SDS-PAGE analysis. SEM micrographs revealed unusual morphological changes such as cell elongation, cocci-shaped cells with crosswalls and distorted cells with bulbous ends. With TEM observed changes included among others, condensation of cytoplasmic material, disintegration of membranes and loss of structural integrity. SDS-PAGE analysis did not reveal any differences in whole cell protein profiles of untreated and garlic clove extract treated cells. The current study is the first to reveal the mechanism of action of garlic clove extract on probiotic Bifidobacterium species. The results indicate that garlic affect these beneficial bacteria in a manner similar to that exhibited in pathogens. These results therefore further highlight that caution should be taken especially when using raw garlic and probiotic bifidobacteria simultaneously as viability of these bacteria could be reduced by allicin released upon crushing of garlic cloves, thereby limiting the health benefits that the consumer anticipate to gain from probiotics.1

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Inhibitory effect of garlic extract on oral bacteria

Cited by 244 publications

References 31 publications

Isolation of Actinobacillus Actinomycetumcomitans (Aggregobacter) Andporphyromonas Gingivalis From Sudanese Aggressive Periodontitis Patients and Testing Inhibitory Effect of Garlic Extract Compared to Chlorhexidine Digluconate 0.2%.

Isolation of Actinobacillus Actinomycetumcomitans (Aggregobacter) Andporphyromonas Gingivalis From Sudanese Aggressive Periodontitis Patients and Testing Inhibitory Effect of Garlic Extract Compared to Chlorhexidine Digluconate 0.2%.

Antimicrobial activity of the essential oil from Lippia sidoides, carvacrol and thymol against oral pathogens

In Vitro Antibacterial Mechanism of Action of Crude Garlic (Allium sativum) Clove Extract on Selected Probiotic Bifidobacterium Species as Revealed by SEM, TEM, and SDS-PAGE Analysis

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