Inhibitory effect of mandarin juice rich in β-cryptoxanthin and hesperidin on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary tumorigenesis in mice

Dietary β-cryptoxanthin inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice

“…The oxygenated carotenoid ß-cryptoxanthin is one of the major carotenoids in the blood, and recent epidemiological studies revealed an inverse association between serum and diet concentrations of ß-cryptoxanthin and the risks of cancer in various organs (46)(47)(48)(49), including the urinary bladder (50). ß-cryptoxanthin is non-toxic as found in this study and previous long-term in vivo experiments (14)(15)(16)(17). Therefore, it is worthy to investigate the relationship between the intake of ß-cryptoxanthin and occurrence of malignant neoplasms in other sites.…”

“…ß-cryptoxanthin is able to inhibit chemically-induced carcinogenesis in mouse skin (14) and rat colon (15,16). In addition, treatment with mandarin juices rich in ß-cryptoxanthin and hesperidin also suppress rat colon (16) and mouse lung carcinogenesis (17). Furthermore, certain epidemiological studies suggest that serum level of ß-cryptoxanthin is inversely correlated with the risk of cancer development in esophagus (18), cervix (19), lung (20,21), and the bladder (22).…”

Medicinal and Edible Plants as Cancer Preventive Agents

“…The peel has been used as a crude drug for gastric secretion promotion, anti-allergic action, inhibition of airway contraction, and sedative effect. Oral administration of unshu mikan juice inhibited colon carcinogenesis by azoxymethane (AOM) (Tanaka, et al, 2000), and lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in mice (Kohno, et al, 2001). Unshu mikan contains high amounts of -cryptoxanthin and hesperidin.…”

Effects of Oxygenated Carotenoid β-Cryptoxanthin on Morphological Differentiation and Apoptosis in Neuro2a Neuroblastoma Cells

“…This bCx had been received attention as a possible protector against carcinogenesis. [7][8][9] Otherwise, there are no previous reports on a neuronal function of bCx in neuronal cell line. This study was done to investigate whether or not bCx has a potential eŠect on neuronal function.…”

“…Several pieces of evidence suggest that dietary bCx may prevent cacinogenesis. [7][8][9] Recent evidence suggest that an action mechanism such as the antioxidant potential, modulation of intercellular communication via gap junctions, and alterations in intercellular signaling pathways and regulation of cell apoptosis could contribute to those anticarcinogenic potentials. 12) In this study, we showed that bCx could regulate the diŠerentiation and apoptosis in Neuro2a neuroblastoma cells, but further studies are needed to clarify the mechanisms of neuromodulatory action of bCx demonstrated in this study.…”