Inhibitory effect of N-phenyl-N?-aryl- or alkylthiourea derivatives on the multiplication of some picornaviruses (Coxsackie B1, ECHO 19, and foot-and-mouth disease virus) in cell cultures

Galabov, Angel S.; Shindarov, L; Vassilev, G. N.; Vassileva, R.

doi:10.1007/bf01249666

Cited by 11 publications

(3 citation statements)

References 3 publications

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“…The results of the in vivo tests are a new proof of the relationship between chemical structure and antiviral activity established in vitro for these compounds (3,4).…”

Section: Discussionmentioning

confidence: 89%

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Antiviral Activity of N -Phenyl- N ′-Aryl- or Alkylthiourea Derivatives in Coxsackie Virus Infections in Mice

Galabov

Velichkova

1974

Antimicrob Agents Chemother

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The effect of five derivatives of N-phenyl-N'-aryl- or alkylthiourea-inhibitors of the multiplication of Coxsackie virus B1 and other picornaviruses in vitro-was tested in experimental infections with Coxsackie viruses B1, B3, A6, and A7 in newborn mice. Under the action of N-phenyl-N'-3-hydroxyphenylthiourea (no. 23) and N-phenyl-N'-4-carboxy-5-hydroxyphenylthiourea (no. 20) a two- to threefold reduction in mortality was observed, as well as an appreciable delay in the course of the disease (mean effective dose, lengthening by 2 to 6 days) after infection with Coxsackie viruses B1, B3, and A7. The infection with Coxsackie virus A6 was affected only by compound no. 23 and, at that, to a low degree. If the antiviral effect is to be obtained, the compounds must be applied daily (once subcutaneously) from the 24th to the 144th h after virus inoculation, a period which corresponds to the incubation period and the beginning of the manifested infection. On the basis of these data, as well as of the relatively high selectivity (therapeutic index of 3 to 20), the two indicated substances may be considered to be reliable antiviral chemotherapeutic agents.

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“…The results of the in vivo tests are a new proof of the relationship between chemical structure and antiviral activity established in vitro for these compounds (3,4).…”

Section: Discussionmentioning

confidence: 89%

“…The derivatives of N-phenyl-N'-arylor alkylthiourea inhibit the multiplication of some picornaviruses-poliovirus 1 (3), Coxsackie virus Bi (4), echovirus 19 (4), encephalomyocarditis virus (A. S. Galabov, unpublished data), and foot-and-mouth disease virus type C (4) in cell cultures, the inhibitory effect attaining 99.9%.…”

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confidence: 97%

Antiviral Activity of N -Phenyl- N ′-Aryl- or Alkylthiourea Derivatives in Coxsackie Virus Infections in Mice

Galabov

Velichkova

1974

Antimicrob Agents Chemother

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“…In previous publications [6,7] we have established high activity of the N-phenyl-N'-aryl-or alkylthiourea derivatives in suppressing human en teroviruses and foot-and-mouth disease virus multiplication. The present communication aims at discussing the results of studying the effect of this group of compounds on rhinovirus growth in cell cultures.…”

mentioning

confidence: 99%

Antiviral Activity of N-Phenyl-N′-arylthiourea Derivatives against some Rhinoviruses

Galabov¹,

Velichkova²,

Vassilev³

1977

Chemotherapy

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The effect of 12 derivatives of N-phenyl-N′-aryl- or alkylthiourea, inhibitors of human enteroviruses and foot-and-mouth disease virus, on reproduction of some rhinoviruses (H-17, B-632) in HeLa Bristol cells was studied. As screening methods both the multicycle growth test in roller tube cultures and two variants of plaque inhibition tests were employed. The compounds selected were tested in one-step growth cycle set-up. We established that N-phenyl-N′-4-hydroxyphenyl-thiourea (V-24) and N-phenyl-N′-2-carboxyphenylthiourea (V-17) have a distinct inhibitory effect on the growth of rhinovirus H-17, and N-phenyl-N′-2-hydroxy-5-nitrophenylthiourea (V-25) inhibited strongly the multiplication of rhinovirus B-632.

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Enhanced inhibition of plant virus replication by pyridylthiourea compounds complexed with metal ions

1989

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Inhibitory effect of N-phenyl-N?-aryl- or alkylthiourea derivatives on the multiplication of some picornaviruses (Coxsackie B1, ECHO 19, and foot-and-mouth disease virus) in cell cultures

Cited by 11 publications

References 3 publications

Antiviral Activity of N -Phenyl- N ′-Aryl- or Alkylthiourea Derivatives in Coxsackie Virus Infections in Mice

Antiviral Activity of N -Phenyl- N ′-Aryl- or Alkylthiourea Derivatives in Coxsackie Virus Infections in Mice

Antiviral Activity of N-Phenyl-N′-arylthiourea Derivatives against some Rhinoviruses

Enhanced inhibition of plant virus replication by pyridylthiourea compounds complexed with metal ions

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