Inhibitory effect of resveratrol on proteinuria, hypoalbuminemia and hyperlipidemia in nephritic rats

Protective effect of ursodeoxycholic acid, resveratrol, andN-acetylcysteine on nonalcoholic fatty liver disease in rats

“…Mechanisms may include RSV activation of AMP-activated protein kinase C and SIRT1 (Deng et al, 2007;Pfluger et al, 2008;Tamaki et al, 2014). Concerning the effect of RSV on hypoalbuminemia, previous authors reported that serum albumin concentration was increased by RSV in the course of treatment of nephritic syndrome in rats (Nihei et al, 2001). An antidiabetic potential for NAC was reported experimentally in different animal models (Bajaj & Khan, 2012;Murata et al, 2003).…”

Resveratrol inhibits fatty acid and triacylglycerol synthesis in rat hepatocytes

“…Like other phenolic compounds, resveratrol is assumed to protect against atherosclerosis and coronary heart disease by reducing the peroxidative degradation of LDL [9,28]. The lipid lowering effect of resveratrol has been indicated in tumoral cell lines [14] as well as in in vivo studies [14,15,29]. In the latter, resveratrol was administered for several days or even weeks before changes in lipid metabolism were observed.…”

“…Resveratrol dose-dependently suppressed both serum triacylglycerols (TAG) and very low density lipoprotein (VLDL) + LDL-cholesterol levels in hepatomabearing rats [14], and reduced significantly hyperlipidemia in nephritic rats [15]. In the latter, the hypotriacylglycerolemic action was more prominent than the hypocholesterolemic one [15]. In the above-mentioned studies, resveratrol effects on lipid metabolism were investigated in proliferating cell lines and in vivo studies relative to pathological conditions.…”

Resveratrol And Its Derivative Improves Oxidative Stress and Protects Against Alloxan- Induced Diabetics

“…Diabetes mellitus, the most common endocrine disease, is not a single disease but a group of disorders of varying etiology and pathogenesis current approaches of diabetes therapy involve mainly drugs enhancing insulin secretion while the role of antioxidants as the important agents restore the redox balance of the organism [22], while other studies have suggested that medical herbs may offer a similar degree of efficacy without so many troubles some side effects [23,24]. Figure (1) there were significant decreased in zinc concentration in the drug treated group (0.52±0.026 ppm) in comparison to the normoglycemic group (0.66±0.02ppm), the administration of resveratrol derivative to rabbits resulted in the significant increase of zinc (0.79±0.02 ppm) after sixth weeks of treatment in comparison with control (0.66±0.02ppm).…”