Inhibitory Effect of Some Plant Extracts on Pancreatic Lipase

Gholamhoseinian, Ahmad; Shahouzehi, Beydolah; Sharififar, Fariba

doi:10.3923/ijp.2010.18.24

Cited by 72 publications

(50 citation statements)

References 30 publications

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“…Tannins have strong interactions with metal ions and macromolecules, such as polysaccharides, and the ability to form soluble complexes with several proteins such as digestive enzymes (GHOLAMHOSEINIAN et al, 2010). This ability of tannins to interact with proteins makes this class of substances potent inhibitors of digestive enzymes.…”

Section: Resultsmentioning

confidence: 99%

“…The functionality of phenolic compounds is mainly related to their antioxidant action, that is, free radical scavenger and, therefore, may be associated with the prevention of various diseases such as some types of cancers and cardiovascular diseases (KARAKAYA, 2004;NINFALI et al 2005), and action in the prevention of obesity (GHOLAMHOSEINIAN et al, 2010).…”

Section: Resultsmentioning

confidence: 99%

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MINERALS AND PHENOLIC COMPOUNDS OF CAGAITA FRUITS AT DIFFERENT MATURATION STAGES (Eugenia dysenterica)

et al. 2017

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-Cerrado is the largest biome in the state of Minas Gerais-Brazil, represented by a biodiversity of fruit species, especially cagaita (Eugenia dysenterica). Cagaita fruits are considered an important option for fruit growing, because they are source of phenolic compounds with antioxidant properties and mineral content that can contribute with beneficial health effects. In this study, phenolic compounds were characterized by high-performance liquid chromatography and the mineral content of ripe and unripe cagaita fruits was evaluated. Regarding minerals, ripe and unripe fruits stand out due to their high potassium content. Unripe fruits are rich in boron while ripe fruits are source of this mineral. ripe and unripe cagaita fruits have the following phenolic compounds: gallic, caffeic, vanillic, p-coumaric, siringeic, ferulic and salicylic acids, epicatechin, quercetin and rutin, the highest contents of these compounds are caffeic, p-coumaric, siringeic and ferrulic, epicatechin and rutin identified in unripe fruits, while ripe fruits have high contents of gallic, vanillic and quercetin acids. Thus, cagaita fruits have great potential for food, therapeutic and medicinal applications bringing health benefits. Index terms: Cerrado fruits, Myrtaceae, HPLC-Uv. MINERAIS E COMPOSTOS FENÓLICOS EM DIFERENTES ESTÁDIOS DE MATURAÇÃO DE FRUTOS DE CAGAITEIRA (Eugenia dysenterica)RESUMO -O Cerrado é o maior bioma no Estado de Minas Gerais-Brasil, representado uma biodiversidade de espécies frutíferas, destacando a cagaiteira (Eugenia dysenterica). Frutos de cagaiteira são considerados uma opção importante para fruticultura, por apresentarem fonte de compostos fenólicos com propriedades antioxidantes e teores de minerais que podem contribuir com efeitos benéficos à saúde. Neste estudo, caracterizaram-se os compostos fenólicos por cromatografia líquida de alta eficiência e avaliaram-se os teores de minerais presentes em frutos de cagaiteira em estádio de maturação maduros e verdes. Em relação aos minerais, frutos maduros e verdes destacam-se por serem ricos em potássio. Os frutos verdes são ricos em boro, enquanto os frutos maduros são fonte desse mineral. Nos frutos de cagaiteira maduros e verdes, foram identificados os compostos fenólicos: os ácidos gálico, cafeico, vanílico, p-cumárico, siríngico, ferúlico e salicílico, epicatequina, quercetina e rutina, sendo os maiores teores dos compostos os ácidos cafeico, p-cumárico, siríngico e ferúlico, epicatequina e rutina identificados nos frutos verdes, enquanto para frutos maduros o destaque foi para os ácidos gálico, vanílico esalicílico e quercetina. Assim, frutos de cagaita podem apresentar grande potencial para aplicações alimentares, terapêuticas e medicinais, trazendo benefícios à saúde. Termos de indexação:Frutos do cerrado, Myrtaceae, CLAE-Uv.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

MINERALS AND PHENOLIC COMPOUNDS OF CAGAITA FRUITS AT DIFFERENT MATURATION STAGES (Eugenia dysenterica)

et al. 2017

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“…However, according to a study which was conducted by Gholamhoseinian et al the inhibition percentage of U. urens against pancreatic lipase was 44.7% by using turbidimetric method (39).…”

Section: Discussionmentioning

confidence: 99%

Anti-lipase activity for Portulaca oleracea, Urtica urens, Brassica napus and Lathyrus hierosolymitanus wild plants from Palestine

Jaradat¹,

Zaid²,

Zaghal³

2017

mpj

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Plants are used to the treatment and prevention of many of metabolic, degenerative and cardiovascular diseases. Obesity is one of the most common metabolic diseases which is considered one of the global health problems. The present study aimed to screen anti-lipase effect of Portulaca oleracea, Urtica urens, Brassica napus and Lathyrus hierosolymitanus traditional Palestinian medicinal wild plants. Anti-lipase activity was measured by using porcine pancreatic lipase inhibitory test which was established by using the UV-visible spectrophotometer method, while orlistat (anti-obesity drug) was used as a positive control reference. The porcine pancreatic lipase inhibitory effect for organic and aqueous extracts of Urtica urens were 157 μg/ml and 157.1 μg/ml, respectively. While the anti-lipase IC 50 value for the organic extract of P. oleracea was 262.03 μg/ml. In addition, the aqueous extracts of Brassica napus and Portulaca oleracea have anti-lipase activity with the IC 50 values 296.87 μg/ml and 417.62 μg/ml, respectively. Meanwhile, Lathyrus hierosolymitanus both aqueous and organic extracts were almost inactive. The results showed that Urtica urens, Portulaca oleracea, and Brassica napus have anti-lipase activity, which provided evidence for their folkloric use as functional food and medicine. These three plants could be used as antilipase agents in the pharmaceutical and nutritional industries or may be used as fatty food additives in order to decrease the absorption and digestion of fats from food. Keywords

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“…Therefore, researches need to find natural anti-obesity compound to avoid the side effects. Now, a lot of extracts from hundreds of species of plants [6] and marine algae [7] as well as the metabolites from microorganisms [8] are being screened for their lipase inhibitory activity. In the research of effective antiobesity agents, several categories of natural compounds such as polyphenols, saponins, triterpenes, flavonoids, some certain proteins and basic polysaccharides show potent inhibitory activity against PL [4].…”

Section: Introductionmentioning

confidence: 99%

The Inhibitory Effect of Different Solvents Extracts from Walnut Shell (<i>Juglans regia </i><i>L.</i>) on Pancreatic Lipase and Adipogenesis of 3T3-L1 Preadipocytes

Yang¹,

Chen²,

Zhao³

et al. 2014

JFNR

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In this article, the effect of the solvents (water, methanol, ethanol, chloroform, N-butanol and ethyl acetate) on the extraction yields (EY), total flavonoids content (TFC), total phenols content (TPC) form walnut shell and the inhibitory effect of extracts on pancreatic lipase were analysed. The kinetics of enzyme inhibition and was investigated. The inhibitory effect of extracts on adipogenesis of 3T3-L1 preadipocytes was also investigated. The highest EY, TFC and TPC were achieved with N-butanol (4.54%), Ethyl acetate (80.40 mg QEs/g extract) and ethyl acetate (200.40 mg GAE/g extract). The order of inhibitory activity was methanol extract (ME) > ethyl acetate extract (EAE) > ethanol extract (EE) > water extract (WE) > N-butanol extract (NBE) > chloroform extract (CE), the inhibition ratios were 82.51%, 73.13%, 70.49%, 69.42%, 65.57% and 60.66%, respectively under the concentration of 500 μg/mL. The IC 50 values of WE, ME, EE, CE, NBE and EAE were 371.35, 308.91, 407.57, 196.50, 247.79 and 254.27 μg/mL respectively. The inhibitory types of walnut shell extracts were noncompetitive. All the extracts were non-toxic to 3T3-L1 preadipocytes. The ME, EE, CE, NBE and EAE have inhibitory effect on triglyceride accumulation of 3T3-L1 cells.

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Inhibitory Effect of Some Plant Extracts on Pancreatic Lipase

Cited by 72 publications

References 30 publications

MINERALS AND PHENOLIC COMPOUNDS OF CAGAITA FRUITS AT DIFFERENT MATURATION STAGES (Eugenia dysenterica)

MINERALS AND PHENOLIC COMPOUNDS OF CAGAITA FRUITS AT DIFFERENT MATURATION STAGES (Eugenia dysenterica)

Anti-lipase activity for Portulaca oleracea, Urtica urens, Brassica napus and Lathyrus hierosolymitanus wild plants from Palestine

The Inhibitory Effect of Different Solvents Extracts from Walnut Shell (<i>Juglans regia </i><i>L.</i>) on Pancreatic Lipase and Adipogenesis of 3T3-L1 Preadipocytes

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