Inhibitory effect of tannins from galls of Carpinus tschonoskii on the degranulation of RBL-2H3 Cells

Yamada, Parida; Ono, Takako; Shigemori, Hideyuki; Han, Jianzhong; Isoda, Hiroko

doi:10.1007/s10616-012-9457-y

Cited by 12 publications

(6 citation statements)

References 38 publications

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“…Casu isolated from different plant species such as Carpinus tschonoskii and strawberry is able to inhibit allergic reactions induced by BSA (bovine serum albumin) and leads to NF-kβ inhibition, exerting a gastric anti-inflammatory function [24,25]. However, the evaluation of Casu anti-inflammatory activity in the presence of sPLA2 as a pro-inflammatory agent is essential considering the fundamental role of this enzyme in the inflammatory process [26].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Inhibitory Potential of Casuarictin, an Ellagitannin Isolated from White Mangrove (Laguncularia racemosa) Leaves, on Snake Venom Secretory Phospholipase A2

et al. 2019

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Ellagitannins constitute the largest group of hydrolyzable tannins of plants, and, from this group, casuarictin (Casu) was identified in some plant species. However, to our knowledge, no investigation of secretory phospholipase A2 (sPLA2) inhibition by Casu has been performed yet. Casuarictin was isolated by chromatography n-butanol (n-BuOH) partition of Laguncularia racemosa leaves. The pharmacological and biological effects of Casu were evaluated on isolated sPLA2 from the rattlesnake (Crotalus durissus terrificus) and using a plant bacterial strain. The compound was able to form a protein complex consisting of a stable sPLA2 + Casu complex. Analyses carried out with matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF) revealed that the molecular mass of sPLA2 increased from 14,425.62 to 15,362.74 Da. The enzymatic activity of the sPLA2 + Casu complex was significantly lower than that of native sPLA2. Besides, molecular interactions of Casu with sPLA2 were able to virtually abolish the native edematogenic effect as well as myonecrosis induced by the protein when injected 10 min after sPLA2. Therefore, Casu may be considered a potential anti-inflammatory that can be used to treat edema and myonecrosis induced by serine-secreting phospholipase A2. In addition, the compound also showed great antimicrobial potential.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Inhibitory Potential of Casuarictin, an Ellagitannin Isolated from White Mangrove (Laguncularia racemosa) Leaves, on Snake Venom Secretory Phospholipase A2

et al. 2019

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“…Two more hydrolysable tannins found in P. lactiflora have potential for allergic disease. Strictinin (25-100 μM), a component also of tea (Camellia sinensis), inhibits the IgE production pathway in mice, and casuarictin (30 μM) shows mast cell degranulation activity (Tachibana et al, 2001;Yamada et al, 2012).…”

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confidence: 99%

A Pharmacological Review of Bioactive Constituents ofPaeonia lactifloraPallas andPaeonia veitchiiLynch

et al. 2016

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The roots of two peony species, Paeonia lactiflora Pallas and Paeonia veitchii Lynch are routinely referred to as either chishao () or baishao (). This paper reviews the botanical origins and traditional medicinal usage of each species, as well as pharmacological like activity of their constituents. A search of herbal pharmacological encyclopaedia, PubChem and PubMed databases identified their known constituents. The biological data for these constituents were evaluated and classified according to pharmacological-like activity, with emphasis on compounds of greatest concentration and bioavailability. It was found that P. lactiflora and P. veitchii have some common compounds; however, their phytochemical bioavailability varies. Furthermore, a larger number of compounds have been identified in P. lactiflora. These have greater potential for antiinflammatory, antiviral, antibacterial and antioxidant therapeutic activity compared with P. veitchii. However, evidence indicates both species are similarly indicated for antiviral and glycaemic activity. Major compounds of each are classified as flavonoids, hydrolysable tannins (polyphenols) and monoterpene glycosides. The evidence suggests both species, when administered in entire botanical form, have an excellent safety profile; however, constituent toxicity risk evidence is limited, requiring further investigation. Although experiments show many compounds have biological activity, further investigation of their therapeutic potential is needed. Copyright © 2016 John Wiley & Sons, Ltd.

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“…26 TA is an exogenous substance suggested to be capable of inhibiting allergic reactions and which might be useful for the treatment or prevention of type I allergic diseases. 27 However it is also suspected to be an anaphylactoid potential allergen 28 which can cause significant anaphylactoid reaction when used in high concentration as demonstrated in our study. C48/80 is a well-known activator of mast cells via phospholipase D and heterotrimeric GTPbinding proteins.…”

Section: Discussionmentioning

confidence: 50%

The evaluation and optimization of animal model for anaphylactoid reaction induced by injections

Kang²,

Dou³

et al. 2015

Asian Pac J Allergy Immunol

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Background: Recent research indicates that injections inducing unwanted anaphylactoid reactions occur frequently in a clinical setting. In this paper, we explored anaphylactoid reactions trends in animal models following ginsenosides injections. Methods: Our anaphylactoid animal model was optimized by comparing reactions between BN rats, SD rats, guinea pigs and ICR mice to first intravenous exposure to standard compounds including ovalbumin (OVA), tannic acid (TA), Tween 80 (T80), bovine serum albumin (BSA) and Compound 48/80 (C48/80), Shengmai injection (SMI) and Xuesaitong injection (XSTI) which contains ginsenosides, respectively. The anaphylactoid symptoms were documented and the plasma levels of histamine were assessed. Subsequently, the IgE levels and total complement activity (CH50) were determined to further explore the mechanisms underlying the observed anaphylactoid reactions on the optimized animal model. Results: We observed that BN rats and guinea pigs exhibited particularly exacerbated symptoms after administration of OVA, T80, TA, SMI and XSTI. Regarding histamine levels, we observed that BN rats were more sensitive to TA and XSTI, guinea pigs were more sensitive to OVA, T80 and SMI, and SD rats were more sensitive to C48/80. According to both anaphylactoid symptom scores and histamine secretion rates, BN rats, in particular, were found to be more sensitive to OVA, T80, TA, SMI and XSTI. Noteworthy however, the four rodents showed significantly weaker anaphylactoid reactions after administration of BSA. Conclusion: BN rats were more suitable for comprehensive evaluation of anaphylatoid reactions following injections; both IgE levels and CH50 could be used as auxiliary mediators for the assessment of anaphylactoid reactions.

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Inhibitory effect of tannins from galls of Carpinus tschonoskii on the degranulation of RBL-2H3 Cells

Cited by 12 publications

References 38 publications

Evaluation of the Inhibitory Potential of Casuarictin, an Ellagitannin Isolated from White Mangrove (Laguncularia racemosa) Leaves, on Snake Venom Secretory Phospholipase A2

Evaluation of the Inhibitory Potential of Casuarictin, an Ellagitannin Isolated from White Mangrove (Laguncularia racemosa) Leaves, on Snake Venom Secretory Phospholipase A2

A Pharmacological Review of Bioactive Constituents ofPaeonia lactifloraPallas andPaeonia veitchiiLynch

The evaluation and optimization of animal model for anaphylactoid reaction induced by injections

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