Inhibitory effect of thyrotropin releasing hormone on spontaneous proliferation of mouse spleen lymphocytes in vitro

Kunert‐Radek, Jolanta; Pawlikowski, Marek; Stępień, H; Janecka, Anna

doi:10.1016/0006-291x(91)91226-3

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…High levels of TRH receptor mRNA have recently been found in the rat thymus [20]. In our earlier study, we showed that TRH inhibited the proliferation of murine spleen lymphocytes in vitro [21]. Summing up, the present study supports the earlier observations indicating the involvement of the TRH-TSH axis in the neuroendocrine control of the thymus.…”

Section: Discussionsupporting

confidence: 80%

Time of Day-Dependent Effects of Thyroliberin and Thyrotropin on Thymocyte Proliferation in Rats

Winczyk

Pawlikowski

2000

Neuroimmunomodulation

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Our earlier studies have shown that thyroliberin (TRH) as well as thyrotropin (TSH) enhanced thymus cell proliferation. The aim of the present study was to investigate whether the effects of TRH and TSH on thymocyte proliferation depend on time of day. A single subcutaneous injection of TRH (25 μg/animal) or TSH (3 IU/animal) was made at 9:00 h (1 h after light onset) or at 18:00 h (10 h after light onset) in 3-month-old male Wistar rats. The animals were killed 24 h later. The proliferation of thymocytes was assessed by incorporation of bromodeoxyuridine into cell nuclei. Thymocyte proliferation was significantly increased by TSH administration at 9:00 h, whereas treatment given at 18:00 h was ineffective. TRH enhanced the proliferation when injected at 9:00 h, but had an inhibitory effect when administered at 18:00 h. These data indicate that the effects of TRH and TSH on thymocyte proliferation are dependent on time of day.

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Section: Discussionsupporting

confidence: 80%

Time of Day-Dependent Effects of Thyroliberin and Thyrotropin on Thymocyte Proliferation in Rats

Winczyk

Pawlikowski

2000

Neuroimmunomodulation

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“…The experimental work of Kunert-Radek et al (1991) addressed the proliferation of murine splenocytes in vitro considering the 3 H-thymidine incorporation into splenocyte DNA as an index of proliferation. They found that TRH suppressed the proliferation of splenocytes.…”

Section: Thyrotropin-releasing Hormone (Trh)mentioning

confidence: 99%

Hypothalamic neurohormones and immune responses

Quintanar¹,

Guzmán-Soto²

2013

Front. Integr. Neurosci.

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The aim of this review is to provide a comprehensive examination of the current literature describing the neural-immune interactions, with emphasis on the most recent findings of the effects of neurohormones on immune system. Particularly, the role of hypothalamic hormones such as Thyrotropin-releasing hormone (TRH), Corticotropin-releasing hormone (CRH) and Gonadotropin-releasing hormone (GnRH). In the past few years, interest has been raised in extrapituitary actions of these neurohormones due to their receptors have been found in many non-pituitary tissues. Also, the receptors are present in immune cells, suggesting an autocrine or paracrine role within the immune system. In general, these neurohormones have been reported to exert immunomodulatory effects on cell proliferation, immune mediators release and cell function. The implications of these findings in understanding the network of hypothalamic neuropeptides and immune system are discussed.

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“…Thus, TRH may inhibit the ability of monocytes to produce reactive oxygen important in the destruction of microbes (24). TRH inhibits IgG production (25) and spontaneous proliferation of mouse spleen lymphocytes in vitro (26), and it inhibits the proliferation of the GH4 rat pituitary cells by blocking their entry into the S phase (27). Thus, the inhibition of cell growth might be a more generalized action of TRH.…”

Section: Discussionmentioning

confidence: 99%

Suppressive effect of TRH and antidepressants on human interferon-γ productionin vitro

Kubera

Kenis

Basta‐Kaim

et al. 2002

Acta Neuropsychiatr.

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Inhibitory effect of thyrotropin releasing hormone on spontaneous proliferation of mouse spleen lymphocytes in vitro

Cited by 5 publications

References 6 publications

Time of Day-Dependent Effects of Thyroliberin and Thyrotropin on Thymocyte Proliferation in Rats

Time of Day-Dependent Effects of Thyroliberin and Thyrotropin on Thymocyte Proliferation in Rats

Hypothalamic neurohormones and immune responses

Suppressive effect of TRH and antidepressants on human interferon-γ productionin vitro

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