Inhibitory effects of ketotifen on eotaxin‐dependent activation of eosinophils: consequences for allergic eye diseases

Abstract

Through inhibition of chemotaxis, ketotifen might limit the number of eosinophils at the inflammation site during allergic reaction. Furthermore, inhibition by ketotifen of main inflammatory mediators release suggests a potential role of the drug in limiting the pathological potential of eosinophils.

Caffeic acid phenethyl ester attenuates allergic airway inflammation and hyperresponsiveness in murine model of ovalbumin-induced asthma

“…Many studies have shown an increased production of ROS in asthma, allergic rhinitis, and atopy dermatitis, which contributes, in part, to tissue injury at sites of inflammation (Bowler and Crapo, 2002). A respiratory burst of eosinophils activated by eotaxin has been demonstrated, leading to production of ROS (Woerly et al, 2003;Elsner et al, 1998). We examined the effect of CAPE on generation of ROS, as described in Fig.…”

ORIGINAL ARTICLE Effect of Ketotifen Fumarate, Olopatadine, and Levocabastine on Ocular Active Anaphylaxis in the Guinea Pig and Ocular Immediate Hypersensitivity in the Albino Rat

“…Ketotifen, indeed, prevents late-phase anaphylactic events such as platelet-activating factor (PAF)-mediated reactions 11 as well as eosinophil chemotaxis and activation. 12 This paper reports the effects of ketotifen fumarate (Zaditen Ophtha R , 0.025% ophthalmic solution), olopatadine (Patanol R , 0.1% ophthalmic solution), and levocabastine (Levophta R , 0.05% ophthalmic suspension) in two different animal models. Ocular active anaphylaxis was studied in guinea pigs and ocular immediate hypersensitivity in albino rats.…”

Formyl Peptide Receptor-Like 2 Is Expressed and Functional in Plasmacytoid Dendritic Cells, Tissue-Specific Macrophage Subpopulations, and Eosinophils

“…The production of reactive oxygen species (ROS) from eosinophils was analyzed as previously described by a luminol-dependent chemiluminescence assay (29). Purified eosinophils (3 ϫ 10 5 cells) were incubated in 25 l of RPMI 1640 without phenol red in white 96-well plates for 30 min at 37°C in 5% CO 2 .…”