Inhibitory effects of maslinic acid upon human esophagus, stomach and pancreatic cancer cells

Lin, Chih Kuang; Yan, Sheng-Lei; Yin, Mei‐chin

doi:10.1016/j.jff.2014.08.020

Cited by 16 publications

(8 citation statements)

References 28 publications

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“…Apigenin in high concentration (90 µM) inhibited over 90% wound healing in both pancreatic cancer cell lines. In addition, the Hsp90 client protein MMP-9 is reported to degrade the extracellular matrix and promote the mobility of various cancer cells (Lin, Yan, & Yin, 2014). Our western blotting data showed that MMP-9 was significantly decreased by apigenin in both time-and dose-dependent manner (Fig.…”

Section: Apigenin Inhibits Pancreatic Cancer Cell Migrationmentioning

confidence: 72%

Natural plant flavonoid apigenin directly disrupts Hsp90/Cdc37 complex and inhibits pancreatic cancer cell growth and migration

Ning

Wang

et al. 2015

Journal of Functional Foods

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Section: Apigenin Inhibits Pancreatic Cancer Cell Migrationmentioning

confidence: 72%

Natural plant flavonoid apigenin directly disrupts Hsp90/Cdc37 complex and inhibits pancreatic cancer cell growth and migration

Ning

Wang

et al. 2015

Journal of Functional Foods

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“…OE33, a human esophageal squamous cancer cell line, and A549, a NSCLC cell line, have been widely used to investigate the apoptotic effects and possible mechanism of certain compounds against esophagus cancer and NSCLC. 8,9 In the present study, both cancer cell lines were also used to examine the cytotoxic potential and action mode of RA at various concentrations.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Apoptotic Effects of Rotundic Acid on Human Esophagus and Lung Cancer Cells

Lin

Yin

2016

Integr Cancer Ther

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Rotundic acid (RA) is a pentacyclic triterpenic acid. Apoptotic effects of RA at 4, 8, or 16 µM in OE33 and A549 cell lines, an esophageal squamous cancer cell line and a non-small-cell lung cancer cell line, were examined. RA at 4 to 16 µM inhibited the survival of both cell lines. RA at 8 and 16 µM decreased Bcl-2 expression and at 4 to 16 µM upregulated Bax and cleaved caspase-3 expression. RA treatments decreased the ratio of Bcl-2/Bax in those cells. RA at 4 to 16 µM lowered Na-K-ATPase activity and reduced mitochondrial membrane potential in OE33 and A549 cells. RA at 8 and 16 µM enhanced DNA fragmentation and caspase-3 and caspase-9 expression in OE33 cells. In A549 cells, RA increased caspase-3 expression in a concentration-dependent manner; but only at 8 and 16 µM, it upregulated caspase-9 expression. RA treatments at 4 to 16 µM decreased protein kinase c activity, suppressed the expression of cytochrome c and apoptosis-inducing factor, and lowered the production of reactive oxygen species, vascular endothelial growth factor, transforming growth factor-β1, and tumor necrosis factor-α in both cell lines. RA at 8 and 16 µM downregulated hypoxia-inducible factor-1α expression. These findings suggest that RA could penetrate into OE33 and A549 cells and execute cytotoxic activities.

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“…To illustrate the point, maslinic acid is a natural pentacyclic triterpene, frequently found in olive oil and medicinal plants such as Aster yunnanensis and Eugenia gustavioides. Maslinic acid and its derivatives had been reported by many research groups with apoptotic activities against different cancer cell lines (Juan et al, 2008;Lin et al, 2014;Parra et al, 2011;Bianka Siewert et al, 2013); however, the exact mechanism remains elusive. Through comparative proteomic study, it was reported that in maslinic acid-treated cancer cells, the expressions of dUTPase and stathmin (two cancer proteins involved in inducing early S and G2 cell cycle arrest) were down-regulated (Yap et al, 2012).…”

Section: Phytochemical-mediated Cancer Protein Targetsmentioning

confidence: 99%

Phytochemical-mediated Protein Expression Profiling and the Potential Applications in Therapeutic Drug Target Identifications

Wong

Tan

Chai

2015

Critical Reviews in Food Science and Nutrition

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Many phytochemicals derived from edible medicinal plants have been investigated intensively for their various bioactivities. However, the detailed mechanism and their corresponding molecular targets frequently remain elusive. In this review, we present a summary of the research works done on phytochemical-mediated molecular targets, identified via proteomic approach. Concurrently, we also highlighted some pharmaceutical drugs which could be traced back to their origins in phytochemicals. For ease of presentation, these identified protein targets were categorized into two important healthcare-related fields, namely anti-bacterial and anti-cancer research. Through this review, we hope to highlight the usefulness of comparative proteomic as a powerful tool in phytochemical-mediated protein target identifications. Likewise, we wish to inspire further investigations on some of these protein targets identified over the last few years. With contributions from all researchers, the accumulative efforts could eventually lead to the discovery of some target-specific, low-toxicity therapeutic agents.

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Inhibitory effects of maslinic acid upon human esophagus, stomach and pancreatic cancer cells

Cited by 16 publications

References 28 publications

Natural plant flavonoid apigenin directly disrupts Hsp90/Cdc37 complex and inhibits pancreatic cancer cell growth and migration

Natural plant flavonoid apigenin directly disrupts Hsp90/Cdc37 complex and inhibits pancreatic cancer cell growth and migration

RETRACTED: Apoptotic Effects of Rotundic Acid on Human Esophagus and Lung Cancer Cells

Phytochemical-mediated Protein Expression Profiling and the Potential Applications in Therapeutic Drug Target Identifications

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