Inhibitory effects of Piper betle on production of allergic mediators by bone marrow-derived mast cells and lung epithelial cells

Piper nigrum, Piper betle and Gnetum gnemon- Natural Food Sourcewith Anti-Quorum Sensing Properties

“…It is used in treatment for asthma, cough, diabetes and heart problems [24]. On the other hand, Piper betle (common name: betle leaves) was shown to contain compounds that have anti-diabetic and anti-allergic effects [25,26]. Gnetum gnemon (common name: belinjo leaves) fruits and leaves are consumed in Southeast Asians countries and the study conducted by Kato et al [27] found that the seeds of G. gnemon have anti-oxidant properties.…”

Improving the knowledge on Piper betle: Targeted metabolite analysis and effect on acetylcholinesterase

“…They are tastefully eaten by people in India as they taste warm, aromatic and bitter. They are also largely consumed as a mouth freshener and masticator [1], being additionally credited with many biological properties, such as antioxidant [2,3], antimicrobial [4][5][6][7][8], anti-allergic [9], gastroprotective [10], immunomodulator [11], anti-inflammatory [12], chemopreventive [13] and xanthine oxidase inhibitor [14]. As folk medicine, betel leaf is traditionally known to be useful in the treatment of several situations, like boils and abscesses, conjunctivitis, constipation, headache, hysteria, itches, mastitis, mastoiditis, leucorrhoea, otorrhoea, ringworm, swelling of gum, rheumatism, abrasion, bad breath, cuts and injuries [1].…”

The n-hexane and chloroform fractions of Piper betle L. trigger different arms of immune responses in BALB/c mice and exhibit antifilarial activity against human lymphatic filarid Brugia malayi

“…The alcoholic extract of P. betle leaves is known to exert potent anti-leishmanial, anti-amoebic, anti-giardial, anti-microbial and larvicidal properties [42][43][44][45][46]. The ethanolic leaf extract of P. betle at 100 mg kg − 1 has earlier been shown to possess IL-12 inhibitory property in rat, thus indicating the ability of leaf extract to downregulate Th1 pro-inflammatory responses [47].…”

“…Leaves of betel vine have been used with condiments such as areca nut, kattha, cloves, cardamom, fennel and candied rose for chewing purposes and nearly one billion people consume it daily in one form or the other globally [6]. The betel leaves act as breath-freshener and are used in the Indian system of medicine and health and include medicinal properties such as digestive, antacid, decongestant, carminative, stimulant, antipyretic, anti-inflammatory, anti-allergic, anti-septic, hepatoprotective, radio-protective, anti-fungal, anti-platelet, anti-fertility, nematocidal and anti-oxidant [7][8][9][10][11][12][13][14][15][16]. The chief constituent of the leaves is a volatile oil which contains phenols, betel-phenol; chavibetol and chavicol; cadinene and hydroxychavicol, which have been ascribed to possess anti-oxidant and anti-carcinogenic activities [8,17].…”