Inhibitory effects of Schizandrae Fructus on eotaxin secretion in A549 human epithelial cells and eosinophil migration

Lilium lancifolium Thunb. extract attenuates pulmonary inflammation and air space enlargement in a cigarette smoke-exposed mouse model

“…Herbal extracts have long been used as part of traditional Korean medicine, and have been used effectively to treat a variety of inflammatory disorders (Lim et al, 2009;Oh et al, 2009;Ra et al, 2010;Xue et al, 2011). For example, according to the DonguiBogam, a book edited by the royal physician Heo Jun and published in 1613 during the Joseon Dynasty of Korea, the root of Lilium lancifolium Thunb.…”

Effects of schizandrin on the expression of thymic stromal lymphopoietin in human mast cell line HMC-1

“…In this study, schizandrin inhibited the expression and production of TSLP through the inhibition of caspase-1 and NF-κB pathways. Previous studies reported that schizandrin reduced the protein expressions of TNF-α and IL-4 in IgE-induced RBL 2H3 cells and inhibited the secretion of eotaxin in A549 cells Oh et al, 2009). Furthermore, schizandrin reduced the levels of IL-4, IL-5, IFN-γ, and TNF-α in bronchoalveolar lavage fluid in a murine asthma model .…”

Antiasthmatic effects of schizandrae fructus extract in mice with asthma

“…[29] In a previous study, both SF and schizandrin lowered the levels of eotaxin. [31] In addition, SF decreased messenger ribonucleic acid expression levels in the A549 cells. In particular, eosinophil recruitment to lung epithelial cells was also reduced by SF in vitro .…”

“…In particular, eosinophil recruitment to lung epithelial cells was also reduced by SF in vitro . [31] For these reasons, the suppressive effect of SF on eosinophil infiltration might be one of the possible mechanisms involved in antihyperresponsive action of SF.…”