Inhomogeneity of photo-induced fat cell lipolysis

Abstract

The effect of optical properties changes of adipose tissue cells in vitro as a result of photoaction was found and investigated. The experimental study of photo-induced post action upon the cells of fat tissue by means of digital microscopy was fulfilled. The computer processing of digital photos obtained gave an opportunity to estimate quantitatively the level of photoaction upon tissue. Optical interpretation of photos obtained proves that the phenomenon observed corresponds to the lipolysis of adipose tissue cells, but without their complete destruction.

Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy

“…The result was also the cell lipolysis. The hypothesis of pore formation is in good agreement with the experimental results [37, 206,220,224]. Fig.…”

“…The heating and coagulation of a tissue change its optical properties, and this should be taken into account in the calculation of the radiation doze in the process of treatment [3,22]. The method of controlling optical properties of fat tissue, which is usually a strongly scattering tissue, was proposed in [205,206]. The method is based on the combined photochemical and photothermal effect [2,207] induced in the fat tissue cells.…”

Fat tissue histological study at NIR laser treatment of the skin in vivo

“…[24][25][26] ICG tissue staining may induce the photodynamic effect. [16][17][18][19][20][27][28][29] Relatively narrow absorption peak of this dye allow for effective use in selective laser destruction of tissues, but caution should be accounted for because dye molecules at interaction with organic molecules of a tissue change their absorption spectrum peaks up to 10-20 nm. [27][28][29][30] The intensity and position of the absorption bands depend on the ICG solvents used.…”

“…5,[16][17][18][19][20] In particular, it relates to the employment of localized optical (laser) radiation of the appropriate wavelength and power, which also may be integrated in conjunction with localized specific fat tissue staining or lipolytic agent application, to noninvasive and non-or least-destructively downsize fat tissue volume and thereby modify contour/shape local target adipose tissue.…”

trans-Cinnamic Acid Conjugated Gold Nanoparticles as Potent Therapeutics against Brain-Eating Amoeba Naegleria fowleri

“…Nanoparticles are subcolloidal metallic particles within the size range of nanometer scale. For example, gold nanoparticles of size lower than 20 nm have been conjugated with diverse cellular functions targeting peptides which can infiltrate the cell membrane to reach in the nucleus. , Gold nanoparticles hold significant value in the drug delivery and diagnostic applications due to their tunable physicochemical properties, strong optical absorption, and high biocompatibility . Nanoparticles are also known to enhance the bioactivity of drugs by high drug loading which eventually leads to increased concentration of drugs at target site.…”