Injectable calcium phosphate cement for bone repair and implant fixation

Jansen, John A.; Ooms, E.M.; Wolke, Joop G.C.

doi:10.1016/j.ocl.2004.06.014

Cited by 82 publications

(65 citation statements)

References 32 publications

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“…Probably, this problem can be solved by using a CaP cement, which can be injected in situ and reshaped within the hardening time. 31 Gauthier et al 32 showed that an injectable cement composed of BCP and polymer indeed was favorable compared to a BCP ceramic.…”

Section: Discussionmentioning

confidence: 99%

Bone regeneration of porous β‐tricalcium phosphate (Conduit™ TCP) and of biphasic calcium phosphate ceramic (Biosel®) in trabecular defects in sheep

Bodde

Wolke

Kowalski³

et al. 2007

J Biomedical Materials Res

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In this study bone regeneration between porous beta-tricalcium phosphate (Conduit TCP) and biphasic calcium phosphate ceramic (Biosel), with a hydroxyapatite/beta-TCP ratio of 75/25, was compared. The ceramic particles were implanted in sheep trabecular bone for 3, 12, and 26 weeks. Histomorphometrical analysis revealed that Conduit degraded significantly during time and only 36% of the material was left at 26 weeks implantation time. Biosel, in contrast, remained nearly intact. The degradation of Conduit was due to dissolution as well as cell-mediated. Biosel showed a high cellular intervention, although this material did not degrade. Both materials were osteoconductive. The amount of newly formed bone appeared greater in the Conduit group after 26 weeks (46% +/- 8% as compared to 37% +/- 8% for Biosel), but this difference was not significant. Bone distribution over the defect was homogeneous in Conduit, whereas Biosel showed significantly more bone in the periphery of the defect after 26 weeks in comparison to the center. In conclusion, both ceramics are biocompatible and osteoconductive. Degradation showed a difference in amount and in cellular events, with more degraded Conduit TCP with less cellular intervention as compared to Biosel.

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Section: Discussionmentioning

confidence: 99%

Bone regeneration of porous β‐tricalcium phosphate (Conduit™ TCP) and of biphasic calcium phosphate ceramic (Biosel®) in trabecular defects in sheep

Bodde

Wolke

Kowalski³

et al. 2007

J Biomedical Materials Res

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“…Considering their properties, calcium orthophosphate cements might potentially be applied to reinforce osteoporotic vertebral bodies [512,526]. Further details on this topic are available elsewhere [527,528]. Besides, calcium orthophosphate cements appear to be a reliable subchondral replacement material when the bone defect is adjacent to the articular cartilage [529].…”

Section: Orthopaedic Applicationsmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are a bioactive and biodegradable grafting material in the form of a powder and a liquid. Both phases after mixing form a viscous paste that after being implanted sets and hardens within the body as either a non-stoichiometric calcium deficient hydroxyapatite (CDHA) or brushite, sometimes blended with un-reacted particles and other phases. As both CDHA and brushite are remarkably biocompartible and bioresorbable (therefore, in vivo they can be replaced with a newly forming bone), self-setting calcium orthophosphate cements represent a good correction technique of non-weight-bearing bone fractures or defects and appear to be very promising materials for bone grafting applications. Besides, these cements possess an excellent osteoconductivity, molding capabilities, and easy manipulation. Nearly perfect adaptation to the tissue surfaces in bone defects and a gradual bioresorption followed by new bone formation are additional distinctive advantages of calcium orthophosphate cements. Besides, reinforced formulations are available; those are described as calcium orthophosphate concretes. Furthermore, formulations with high viscosity, such as pastes and putties are also known. The discovery of self-setting formulations has opened up a new era in the medical application of calcium orthophosphates; several commercial compositions have already been introduced as a result. Many more formulations are in experimental stages. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent biomaterials suitable for both dental and bone grafting applications, has been provided.

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“…One study showed that its calcium phosphate cement had an initial set time of 2.75 minutes, a final set time of 7.5 minutes at 37ºC, and a final compressive strength of 48MPa at 24 hours (the maximum compression strength of cancellous bone is 30MPa). 77 A study of the calcium phosphate cement…”

Section: A Comparison Of Mineral Bone Graft Substitutes For Bone Defectsmentioning

confidence: 99%

A Comparison of Mineral Bone Graft Substitutes for Bone Defects

Allison¹,

Lindberg²,

Samimi³

et al. 2011

Oncology &Amp; Hematology Review (US)

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Cavitary bone defects are created in the curettage or debridement of benign bone tumors, infections, or low-grade malignancies. In order for new bone to fill these defects, the material that resides within must be osteoconductive, or an appropriate scaffolding that prevents non-osseous (fibrous) tissue infiltration, supports the attachment of new osteoblasts and osteoprogenitor cells, and sustains an interconnected structure through which new cells can migrate and new vessels can form. 1The subsequent substance that develops through this osteoconductive step must also be osteoinductive (facilitate the travel of factors and materials for cellular differentiation) and osteogenic (cause the cellular production of new bone) for new bone to form. 1 Current US consensus dictates that in order for this cascade to develop in a bone defect, a graft must be used. In fact, over 500,000 bone graft procedures are performed annually in the US.2 In order to meet the first and crucial step of osteoconductivity, the graft must fill the void and provide a scaffolding on which stem cells can attach;in order to facilitate the next two critical steps, the graft must be non-inflammatory and non-toxic and resorb at a rate roughly equal to that of bone formation. Prospective randomized clinical trials in the treatment of bone tumors are necessary to properly delineate the real indications for bone grafting and to demonstrate the graft's efficacy in this regard. KeywordsMineral ceramic bone graft substitute, bone defect, bone void Disclosure:The authors have no conflicts of interest to declare.

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Injectable calcium phosphate cement for bone repair and implant fixation

Cited by 82 publications

References 32 publications

Bone regeneration of porous β‐tricalcium phosphate (Conduit™ TCP) and of biphasic calcium phosphate ceramic (Biosel®) in trabecular defects in sheep

Bone regeneration of porous β‐tricalcium phosphate (Conduit™ TCP) and of biphasic calcium phosphate ceramic (Biosel®) in trabecular defects in sheep

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

A Comparison of Mineral Bone Graft Substitutes for Bone Defects

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