Injectable polydimethylsiloxane microfiller coated with zwitterionic polymer for enhanced biocompatibility

Hydrophilic Modification Strategies to Enhance the Surface Biocompatibility of Poly(dimethylsiloxane)‐Based Biomaterials for Medical Applications

“…Thus, ECM proteins and synthetic ECMs can be used as implant coatings to reduce the amount of inflammation, regulate protein adhesion and subsequent cytokine release, and control immunomodulation. [221][222][223] Recently, MPC, a zwitterionic polymer, was used to create an artificial ECM to mimic the components that give structure and support to cells and tissues. Subsequently, it has garnered much interest for use as a coating material, mainly for implants and devices in the biomedical field.…”

“…Subsequently, it has garnered much interest for use as a coating material, mainly for implants and devices in the biomedical field. [187,221,222,[224][225][226][227] Over the long-term, covalently attaching MPC to the surface of PDMS diminishes the immune response along with the thickness of the fibrous capsule and levels of inflammatory indicators. [225,226,228] Researchers have reported that based on the inflammatory and fibrosis scores, MPC zwitterion-coated PDMS microfillers reduced the immunological response in a rat model.…”

“…[221,222] Semipermeable hydrogels have been intensively investigated as antifouling implant coverings due to their unique properties, such as high water content, ease of solute transport, and the capacity for numerous active groups for future chemical modification. [221,229] They can be used to encapsulate islets against attack from immune cells by preventing direct physical contact while allowing molecules such as reactive oxygen species, NO, and cytokines to pass freely across the hydrogel network. In addition to delivering anti-inflammatory capability, polymeric hydrogels can include traps for catching proinflammatory signals.…”

“…[225,226,228] Researchers have reported that based on the inflammatory and fibrosis scores, MPC zwitterion-coated PDMS microfillers reduced the immunological response in a rat model. [221,222] Semipermeable hydrogels have been intensively investigated as antifouling implant coverings due to their unique properties, such as high water content, ease of solute transport, and the capacity for numerous active groups for future chemical modification. [221,229] They can be used to encapsulate islets against attack from immune cells by preventing direct physical contact while allowing molecules such as reactive oxygen species, NO, and cytokines to pass freely across the hydrogel network.…”

“…[ 225,226,228 ] Researchers have reported that based on the inflammatory and fibrosis scores, MPC zwitterion‐coated PDMS microfillers reduced the immunological response in a rat model. [ 221,222 ]…”