Injectable Tissue-Adhesive Hydrogel for Photothermal/Chemodynamic Synergistic Antibacterial and Wound Healing Promotion

Abstract

It is an exigent need for the development of hydrogel dressings with desirable injectability, good adhesive, antibacterial, and wound healing promotion properties. Herein, the multifunctional injectable hydrogels with good tissue adhesion are designed based on Ag-doped Mo2C-derived polyoxometalate (AgPOM) nanoparticles, urea, gelatin, and tea polyphenols (TPs) for antibacterial and wound healing acceleration. After being injected into the tissue, urea diffuses out under the concentration gradient, and TPs and gelatin chains recombine to trigger the in situ formation of hydrogel with excellent adhesiveness. AgPOM fixed in the hydrogel could not only react with hydrogen peroxide in the infection site to generate singlet oxygen to kill the bacteria but also convert near-infrared light into heat under 1060 nm laser irradiation to realize sterilization. In vitro studies display the high bactericidal ability of the hydrogel against drug-resistant Staphylococcus aureus and also exhibit a prominent therapeutic effect on infected wounds through synergistic photothermal/chemodynamic therapy and accelerate wound healing. Hence, the injectable hydrogel with AgPOM as the antimicrobial agent can be a novel therapeutic agent for drug-resistant bacteria-infected wounds and wound healing promotion.

A Transparent, Tough and Self-Healable Biopolymeric Composites Hydrogel for Open Wound Management

“…The antibacterial performance is the key property that a dressing material must have to inhibit harmful microorganisms and prevent infection. 62,63 The antibacterial activity of the hydrogel film along with the positive control (Ciprofloxacin antibioticloaded on filter paper) and negative control (PBS on filter paper) was evaluated against Gram-negative E. coli and positive S. aureus bacterial strains using the disc diffusion method. The results of antimicrobial activity shown in Figure 8A−C, show that the negative control did not exhibit an antibacterial response against the selected bacterial strains.…”

Recent progress in nanozymes for the treatment of diabetic wounds

“…Therefore, researchers adopted a variety of strategies to enhance enzyme activity and antibacterial activities of peroxidase mimics. 13,[53][54][55][56][57] Wang et al reported a nanoreactor (GOx-CaPCuPt) with a core-shell structure, the core of which is Cu 2 O/Pt nanozyme, which not only has POD-like activity but also has good photothermal properties. 8 When the nanoreactor enters the traumatic environment, the Ca 3 (PO 4 ) 2 (CaP) layer will be degraded, GOx catalyzes glucose decomposition to further reduce the pH value of the wound, and then Cu 2 O/Pt produces a large amount of ROS through the Fenton reaction for the eradication of bacteria; the photothermal properties of Cu 2 O/Pt nanozymes were used to enhance chemodynamic therapy (CDT) (Fig.…”

“…11,12 However, the emergence of drug-resistant bacteria and the stagnation in the development of new antibiotics lead to the availability of fewer and fewer antibiotics, resulting in the ineffective treatment of infected wounds. [13][14][15][16][17][18][19] In addition to immunosuppression persistent high levels of glucose can lead to neurological, microvascular, and macrovascular lesions, which makes diabetic wounds difficult to heal. 10 Therefore, to accelerate the healing of diabetic wounds, we usually need to control blood glucose levels.…”

Keratin- and VEGF-Incorporated Honey-Based Sponge–Nanofiber Dressing: An Ideal Construct for Wound Healing

“…Wound occurs following skin damage, which includes, but is not limited to, cuts, accidents, burns, and surgery. Damages may lead to infection, chronic nonhealing wound formation, amputations, or even death. – The epidermis and dermis of some severe skin wounds may be entirely destroyed, and the healing process of such wounds may be very long with an impressive tendency to get infected and turn into chronic wounds. – Furthermore, underlying diseases such as diabetes, vascular disease, and cancer could also lead to chronic or difficult-to-heal wounds. In this respect, the utilization of wound dressings, which could efficiently accelerate the healing process and avoid germ entrance to wounded area, appears to be vital. ,– …”