Injury Characteristics and von Willebrand Factor for the Prediction of Acute Respiratory Distress Syndrome in Patients With Burn Injury

Afshar, Majid; Burnham, Ellen L.; Joyce, Cara; Gagnon, R.C.; Dunn, Robert; Albright, Joslyn M.; Ramírez, Luis; Repine, John E.; Netzer, Giora; Kovacs, Elizabeth J.

doi:10.1097/sla.0000000000002795

Cited by 10 publications

(7 citation statements)

References 51 publications

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“…Biomarkers have also been evaluated as potential ARDS predictive instruments. Von Willebrand Factor antigen, a marker of endothelial injury, was predictive of development of ARDS in a small study of patients with nonpulmonary sepsis 104 and a more recent larger study of patients with severe trauma 140 . Angiopoietin-2 (a marker and mediator of endothelial injury) and IL-8 were also found to be elevated in critically ill patients prior to ARDS development 108 .…”

Section: Diagnosis Screening and Preventionmentioning

confidence: 98%

Acute respiratory distress syndrome

Matthay

Zemans

Zimmerman

et al. 2019

Nat Rev Dis Primers

1,741

1,519

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The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in critically ill patients and is defined by the acute onset of noncardiogenic pulmonary edema, hypoxemia, and the need for mechanical ventilation. ARDS occurs most often in the setting of pneumonia, sepsis, aspiration of gastric contents or severe trauma, and is present in ~10% of all intensive care unit patients worldwide. Despite some improvements over the past decades, mortality remains high at 30–40% in most studies. Pathologic specimens from patients with ARDS most frequently reveal diffuse alveolar damage, and laboratory studies have demonstrated both alveolar epithelial and lung endothelial injury, resulting in accumulation of protein-rich inflammatory edema fluid in the alveolar space. Diagnosis is based on consensus syndromic criteria, with recent proposed modifications for under-resourced settings and for pediatric patients. Patient management focuses on implementing a lung-protective ventilation strategy; no specific pharmacotherapies have been identified. Long-term outcomes of patients with ARDS are increasingly recognized as important research targets, as many patients survive ARDS only to suffer ongoing functional and/or psychologic sequelae. Future directions include efforts to facilitate earlier recognition of ARDS, prognostic and/or predictive enrichment in clinical studies to identify responsive subsets, and ongoing efforts to understand fundamental mechanisms of lung injury that may respond to specific treatments.

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Section: Diagnosis Screening and Preventionmentioning

confidence: 98%

Acute respiratory distress syndrome

Matthay

Zemans

Zimmerman

et al. 2019

Nat Rev Dis Primers

1,741

1,519

View full text Add to dashboard Cite

show abstract

“…The pharmacological inhibition of PAD4, by using GSK484 treatment before skin exposure to PAO, also diminished overall lung injury. Furthermore, the suppressed lung injury correlated positively with decreased vWF levels in the plasma ( 50 ) of GSK484-treated mice exposed to PAO. These strategies also worked in the other ALI models, including sepsis and the cecal ligation and puncture–induced ALI model ( 56 – 58 ).…”

Section: Discussionmentioning

confidence: 86%

“…There is a direct correlation of increased NETs and vWF levels in the plasma of subjects with burns ( 21 ). Furthermore, elevated serum vWF is correlated with the development of ARDS in patients with extensive burns ( 50 ). The neutralization of Cit-H3 disrupts this binding, thus inhibiting the effect of Cit-H3 on the endothelial barrier.…”

Section: Discussionmentioning

confidence: 99%

NETosis in the pathogenesis of acute lung injury following cutaneous chemical burns

Surolia¹,

Li²,

Wang³

et al. 2021

JCI Insight

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“…Several predictors and prediction models for predicting the incidence of ARDS in patients with specific diseases or injuries have been reported ( 18 , 25 , 26 ). For instance, Majid et al constructed a 3-variable model comprising total body surface area percent, inhalation injury, and von Willebrand factor-A2 to predict ARDS in patients with burn injuries, with an AUC of 0.90.…”

Section: Discussionmentioning

confidence: 99%

Novel models for early prediction and prevention of acute respiratory distress syndrome in patients following hepatectomy: A clinical translational study based on 1,032 patients

Wang

Zhang²,

Zong³

et al. 2023

Front. Med.

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BackgroundAcute respiratory distress syndrome (ARDS) is a serious organ failure and postoperative complication. However, the incidence rate, early prediction and prevention of postoperative ARDS in patients undergoing hepatectomy remain unidentified.MethodsA total of 1,032 patients undergoing hepatectomy between 2019 and 2020, at the Eastern Hepatobiliary Surgery Hospital were included. Patients in 2019 and 2020 were used as the development and validation cohorts, respectively. The incidence rate of ARDS was assessed. A logistic regression model and a least absolute shrinkage and selection operator (LASSO) regression model were used for constructing ARDS prediction models.ResultsThe incidence of ARDS was 8.8% (43/490) in the development cohort and 5.7% (31/542) in the validation cohort. Operation time, postoperative aspartate aminotransferase (AST), and postoperative hemoglobin (Hb) were all critical predictors identified by the logistic regression model, with an area under the curve (AUC) of 0.804 in the development cohort and 0.752 in the validation cohort. Additionally, nine predictors were identified by the LASSO regression model, with an AUC of 0.848 in the development cohort and 0.786 in the validation cohort.ConclusionWe reported the incidence of ARDS in patients undergoing hepatectomy and developed two simple and practical prediction models for early predicting postoperative ARDS in patients undergoing hepatectomy. These tools may improve clinicians’ ability to early estimate the risk of postoperative ARDS and timely prevent its emergence.

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Injury Characteristics and von Willebrand Factor for the Prediction of Acute Respiratory Distress Syndrome in Patients With Burn Injury

Abstract: The 3-variable model with %TBSA, inhalation injury, and von Willebrand factor could be used to better identify at-risk patients for both the study and prevention of ARDS in patients with burn injury.

Cited by 10 publications

References 51 publications

Acute respiratory distress syndrome

Acute respiratory distress syndrome

NETosis in the pathogenesis of acute lung injury following cutaneous chemical burns

Novel models for early prediction and prevention of acute respiratory distress syndrome in patients following hepatectomy: A clinical translational study based on 1,032 patients

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