Injury-induced Erk1/2 signaling tissue-specifically interacts with Ca2+ activity and is necessary for regeneration of spinal cord and skeletal muscle

Levin, Jacqueline B.; Borodinsky, Laura N.

doi:10.1016/j.ceca.2022.102540

Cited by 10 publications

(5 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The expression of CRGs positively correlates only with robust swimming in fish, which is consistent with a shared role for CRGs in muscle contraction and not in muscle differentiation [84]. Additionally, Ca 2+ has recently been implicated in the proliferation of myogenic progenitor cells during spinal cord and skeletal muscle regeneration in frogs [85], which resembles Ca 2+ ‐induced MyoD activation during myogenic differentiation in mammals. However, the involvement of CRGs in myoblast fusion has not been reported in amphibians, suggesting that the induction of CRGs during late myogenic differentiation and fusion is a feature unique to amniotes.…”

Section: Hypothesis: Ca2+‐signalling Regulates Fusion and Contraction...mentioning

confidence: 65%

See 1 more Smart Citation

Ca²⁺ as a coordinator of skeletal muscle differentiation, fusion and contraction

2022

View full text Add to dashboard Cite

Muscle regeneration is essential for vertebrate muscle homeostasis and recovery after injury. During regeneration, muscle stem cells differentiate into myocytes, which then fuse with pre-existing muscle fibres. Hence, differentiation, fusion and contraction must be tightly regulated during regeneration to avoid the disastrous consequences of premature fusion of myocytes to actively contracting fibres. Cytosolic calcium (Ca 2+ ), which is coupled to both induction of myogenic differentiation and contraction, has more recently been implicated in the regulation of myocyte-to-myotube fusion. In this viewpoint, we propose that Ca 2+ -mediated coordination of differentiation, fusion and contraction is a feature selected in the amniotes to facilitate muscle regeneration.

show abstract

Section: Hypothesis: Ca2+‐signalling Regulates Fusion and Contraction...mentioning

confidence: 65%

“…2). While mammals (amniotes) use SCs‐derived myocytes for fusion, amphibians derive mononucleated cells by dedifferentiating injured myofibers to myocytes that fuse with injured myofibers (dedifferentiation model for muscle regeneration) [85,101–103].…”

Section: Divergent Mechanisms Of Muscle Formation and Growth Between ...mentioning

confidence: 99%

Ca²⁺ as a coordinator of skeletal muscle differentiation, fusion and contraction

2022

View full text Add to dashboard Cite

show abstract

“…It can also induce the release of a cyclic protein known as AIF, leading to cell death [ 20 ]. In addition, Ca 2+ increases the levels of various calcium-dependent enzymes, stimulating the production of lipases and other enzymes [ 33 ].…”

Section: Calcium and Cellular Biology Of Scimentioning

confidence: 99%

“…Ca 2+ dysregulation is a key step in this patho-physiological cascade [ 38 ]. Unfortunately, the field of Ca 2+ dynamics, despite developed electrophysiological and imaging techniques, is not well-supported due to the lack of sufficient evidence supporting its harmful effects [ 33 ]. The results of Ca 2+ overload on the cells can have long-term detrimental effects.…”

Section: Calcium and Cellular Biology Of Scimentioning

confidence: 99%

Main Cations and Cellular Biology of Traumatic Spinal Cord Injury

Munteanu

Rotariu

Turnea

et al. 2022

Cells

View full text Add to dashboard Cite

Traumatic spinal cord injury is a life-changing condition with a significant socio-economic impact on patients, their relatives, their caregivers, and even the community. Despite considerable medical advances, there is still a lack of options for the effective treatment of these patients. The major complexity and significant disabling potential of the pathophysiology that spinal cord trauma triggers are the main factors that have led to incremental scientific research on this topic, including trying to describe the molecular and cellular mechanisms that regulate spinal cord repair and regeneration. Scientists have identified various practical approaches to promote cell growth and survival, remyelination, and neuroplasticity in this part of the central nervous system. This review focuses on specific detailed aspects of the involvement of cations in the cell biology of such pathology and on the possibility of repairing damaged spinal cord tissue. In this context, the cellular biology of sodium, potassium, lithium, calcium, and magnesium is essential for understanding the related pathophysiology and also the possibilities to counteract the harmful effects of traumatic events. Lithium, sodium, potassium—monovalent cations—and calcium and magnesium—bivalent cations—can influence many protein–protein interactions, gene transcription, ion channel functions, cellular energy processes—phosphorylation, oxidation—inflammation, etc. For data systematization and synthesis, we used the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) methodology, trying to make, as far as possible, some order in seeing the “big forest” instead of “trees”. Although we would have expected a large number of articles to address the topic, we were still surprised to find only 51 unique articles after removing duplicates from the 207 articles initially identified. Our article integrates data on many biochemical processes influenced by cations at the molecular level to understand the real possibilities of therapeutic intervention—which must maintain a very narrow balance in cell ion concentrations. Multimolecular, multi-cellular: neuronal cells, glial cells, non-neuronal cells, but also multi-ionic interactions play an important role in the balance between neuro-degenerative pathophysiological processes and the development of effective neuroprotective strategies. This article emphasizes the need for studying cation dynamics as an important future direction.

show abstract

“…It has been proved that ERK1/2 was activated in stem cells of the damaged area. In skeletal muscle associated tissues, the activation of ERK1/2 was necessary for an injury-induced increase in intracellular store-dependent Ca 2+ dynamics, but in spinal cord, injury increases Ca 2+ influx-dependent Ca 2+ activity independent of ERK1/2 signalling ( Levin and Borodinsky, 2022 ). It is obvious to see the vital role of stem cells in muscle repair, and the purpose is to regulate the inflammatory environment by stimulating transformation of stem cells.…”

Section: Msc-evs In Tissue Repair and Regeneration In Oral And Cranio...mentioning

confidence: 99%

Emerging role of mesenchymal stem cell-derived extracellular vesicles in oral and craniomaxillofacial tissue regenerative medicine

Liu

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Mesenchymal stem cells (MSCs) are multipotent stem cells with differentiation potential and paracrine properties, drawing significant attention in the field of regenerative medicine. Extracellular vesicles (EVs), mainly including exosomes, microvesicles and apoptotic bodies (ABs), are predominantly endosomal in origin and contain bioactive molecules, such as miRNAs, mRNAs, and proteins, which are transferred from their original cells to target cells. Recently it has emerged that MSC-derived EVs (MSC-EVs) combine the advantages of MSCs and EVs, which may be used as a promising MSC-based therapy in tissue repair and regeneration. Oral and craniomaxillofacial diseases are clinically complications containing the soft and hard tissues in craniofacial and dental arches. These diseases are often induced by various factors, such as chemical, microbiological, physical factors, and systemic disorders. For decades, tissue repair and regeneration in oral and craniomaxillofacial regions provide substantial improvements in the prevention and treatment of some severe diseases. In this review we discuss MSC-EVs and their therapeutic potential in oral and craniomaxillofacial tissue regenerative medicine.

show abstract

Injury-induced Erk1/2 signaling tissue-specifically interacts with Ca2+ activity and is necessary for regeneration of spinal cord and skeletal muscle

Cited by 10 publications

References 56 publications

Ca²⁺ as a coordinator of skeletal muscle differentiation, fusion and contraction

Ca²⁺ as a coordinator of skeletal muscle differentiation, fusion and contraction

Main Cations and Cellular Biology of Traumatic Spinal Cord Injury

Emerging role of mesenchymal stem cell-derived extracellular vesicles in oral and craniomaxillofacial tissue regenerative medicine

Contact Info

Product

Resources

About

Injury-induced Erk1/2 signaling tissue-specifically interacts with Ca2+ activity and is necessary for regeneration of spinal cord and skeletal muscle

Cited by 10 publications

References 56 publications

Ca2+ as a coordinator of skeletal muscle differentiation, fusion and contraction

Ca2+ as a coordinator of skeletal muscle differentiation, fusion and contraction

Main Cations and Cellular Biology of Traumatic Spinal Cord Injury

Emerging role of mesenchymal stem cell-derived extracellular vesicles in oral and craniomaxillofacial tissue regenerative medicine

Contact Info

Product

Resources

About

Ca²⁺ as a coordinator of skeletal muscle differentiation, fusion and contraction

Ca²⁺ as a coordinator of skeletal muscle differentiation, fusion and contraction