Innate Lymphocytes in Inflammatory Arthritis

Wu, Xunyao

doi:10.3389/fimmu.2020.565275

Cited by 27 publications

(16 citation statements)

References 147 publications

(170 reference statements)

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“…RA results from the loss of immune self-tolerance, autoantigen presentation, and aberrant inflammatory cytokine production caused by abnormal activation of innate and adaptive immune systems (101). Although adaptive immunity (e.g., autoantibody production mediated by CD4 + T cells and B cells) predominates, innate immune cells (e.g., DCs, macrophages, mast cells, and NK cells) have also been implicated in RA pathogenesis (98,102,103).…”

Section: Nk Cells and Rheumatoid Arthritis (Ra)mentioning

confidence: 99%

NK Cells in Autoimmune Diseases: Protective or Pathogenic?

2021

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Autoimmune diseases generally result from the loss of self-tolerance (i.e., failure of the immune system to distinguish self from non-self), and are characterized by autoantibody production and hyperactivation of T cells, which leads to damage of specific or multiple organs. Thus, autoimmune diseases can be classified as organ-specific or systemic. Genetic and environmental factors contribute to the development of autoimmunity. Recent studies have demonstrated the contribution of innate immunity to the onset of autoimmune diseases. Natural killer (NK) cells, which are key components of the innate immune system, have been implicated in the development of multiple autoimmune diseases such as systemic lupus erythematosus, type I diabetes mellitus, and autoimmune liver disease. However, NK cells have both protective and pathogenic roles in autoimmunity depending on the NK cell subset, microenvironment, and disease type or stage. In this work, we review the current knowledge of the varied roles of NK cell subsets in systemic and organic-specific autoimmune diseases and their clinical potential as therapeutic targets.

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Section: Nk Cells and Rheumatoid Arthritis (Ra)mentioning

confidence: 99%

NK Cells in Autoimmune Diseases: Protective or Pathogenic?

2021

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“…These studies highlight the role of IL-9 in the resolution of inflammation in arthritis [130]. In human studies, IL-9-producing IL-C2 cells were also identified in the PBMCs of RA patients [130,131]. In a study of treatment-induced remission of RA, synovial fluid of patients showed high levels of IL-9 [128].…”

Section: Rheumatoid Arthritis (Ra)mentioning

confidence: 83%

“…Type 2 innate lymphoid cells (IL-C2) are documented to express IL-9 and have an anti-inflammatory function [128,129]. These studies highlight the role of IL-9 in the resolution of inflammation in arthritis [130]. In human studies, IL-9-producing IL-C2 cells were also identified in the PBMCs of RA patients [130,131].…”

Section: Rheumatoid Arthritis (Ra)mentioning

confidence: 93%

Therapeutic Potential of IL-9 in Allergic and Autoimmune Diseases

Bintha¹,

Amadou²,

Huzzatul³

et al. 2021

Interleukins - The Immune and Non-Immune Systems’ Related Cytokines

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Interleukin-9 (IL-9) is a pleiotropic cytokine produced by several immune and epithelial cells. Recently, many studies have eluded the physiological and pathological roles of IL-9 and its lineage-specific helper T cell subset (Th9). In this chapter, we will focus on the immunological role of Interleukin 9 (IL-9) in allergy and autoimmunity. We will introduce the basics of IL-9 and describe the cells involved in the secretion, signaling, and regulation of IL-9. After establishing the background, we will discuss the pathogenesis and regulation of IL-9 in allergic and autoimmune diseases. We will conclude the chapter by providing an updated therapeutics that target IL-9 and their potential uses in autoimmune and allergic diseases.

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“…As a messenger between the innate and adaptive immune systems, innate lymphoid cells (ILCs) have been realized to be intensely involved in the pathogenesis of inflammatory arthritis ( 52 , 53 ). In particular, ILC2 acts as a crucial regulator in damping joint inflammation in contrast to proinflammatory ILC1/ILC3.…”

Section: Ilc2–eosinophil–m2 Macrophage Axis Counteracts Joint Inflammationmentioning

confidence: 99%

Emerging Role of Eosinophils in Resolution of Arthritis

Qin

Jin

et al. 2021

Front. Immunol.

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Eosinophils are a minor component of circulating granulocytes, which are classically viewed as end-stage effector cells in host defense against helminth infection and promoting allergic responses. However, a growing body of evidence has emerged showing that eosinophils are versatile leukocytes acting as an orchestrator in the resolution of inflammation. Rheumatoid arthritis (RA) is the most common chronic inflammatory disease characterized by persistent synovitis that hardly resolves spontaneously. Noteworthy, a specific population of eosinophils, that is, regulatory eosinophils (rEos), was identified in the synovium of RA patients, especially in disease remission. Mechanistically, the rEos in the synovium display a unique pro-resolving signature that is distinct from their counterpart in the lung. Herein, we summarize the latest understanding of eosinophils and their emerging role in promoting the resolution of arthritis. This knowledge is crucial to the design of new approaches to rebalancing immune homeostasis in RA, considering that current therapies are centered on inhibiting pro-inflammatory cytokines and mediators rather than fostering the resolution of inflammation.

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Innate Lymphocytes in Inflammatory Arthritis

Cited by 27 publications

References 147 publications

NK Cells in Autoimmune Diseases: Protective or Pathogenic?

NK Cells in Autoimmune Diseases: Protective or Pathogenic?

Therapeutic Potential of IL-9 in Allergic and Autoimmune Diseases

Emerging Role of Eosinophils in Resolution of Arthritis

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