Innate stimulatory capacity of high molecular weight transition metals Au (gold) and Hg (mercury)

Rachmawati, Dessy; Alsalem, Inás W.A.; Bontkes, Hetty J.; Verstege, Marleen I.; Gibbs, S.; Blomberg, B. Mary E. von; Scheper, Rik J.; Hoogstraten, Ingrid M.W. van

doi:10.1016/j.tiv.2014.10.010

Cited by 19 publications

(18 citation statements)

References 28 publications

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“…The nature of the binding was a chelating pocket for the metal in the binding site of TLR4. A similar study described the potential direct triggering of TLR3 by gold in DCs 63 . Quantum dots with either carboxyl or PEG functionalized surfaces were both shown to activate inflammatory responses in macrophages, and these were abrogated by TLR4 inhibition 64 .…”

Section: Critical Features Of Biomaterials For Innate Immune Recognitionmentioning

confidence: 76%

Materials design at the interface of nanoparticles and innate immunity

Szeto

Lavik

2016

J. Mater. Chem. B

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Section: Critical Features Of Biomaterials For Innate Immune Recognitionmentioning

confidence: 76%

Materials design at the interface of nanoparticles and innate immunity

Szeto

Lavik

2016

J. Mater. Chem. B

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“…Rachmawati et al reported that the gold compound (Na 3 Au (S 2 O 3 )2· 2 H 2 O, Figure 2D ) induced substantial release of the pro-inflammatory mediator IL-8 from DC, PBMC, and THP-1 cells and expression of CD40 on the surface of DC, indicating DC's maturation and adaptive immune stimulatory capacity. The ability of this gold compound to induce innate immune responses can be attributed to TLR3 dependent signaling (Rachmawati et al, 2015b ). I. Stern et al observed the effects of auranofin ( Figure 2A ), gold sodium thiomalate ( Figure 2C ), and HAuCl4 [Au (III)] ( Figure 2E ) on the ability of LPS-induced THP1 monocytes to secrete key inflammatory cytokines (IL6, IL8, IL10, and TNF α) in vitro .…”

Section: Antitumor Immune Effects Of Gold Compoundsmentioning

confidence: 99%

Recent Advances of Gold Compounds in Anticancer Immunity

et al. 2020

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In recent years, gold compounds have gained more and more attentions in the design of new metal anticancer drugs. Numerous researches have reported that gold compounds, in addition to their widely studied cytotoxic antitumor effects, also reverse tumor immune escape and directly facilitate the functions of immune cells, leading to enhanced anticancer effects. This review mainly summarizes our current understandings of antitumor effects of gold drugs and their relationships with various aspects of antitumor immunity, including innate immunity, adaptive immunity, immunogenic cell death, and immune checkpoints, as well as their roles in adverse effects. Some recent examples of anticancer gold compounds are highlighted. The property of gold compounds is expected to combine with anticancer immunotherapy, such as immune checkpoint inhibitors, to develop new anticancer therapeutic strategies.

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“…Gold chloride significantly reduced cell viability and led to an induction of apoptosis at 1000 μ m . Other studies reported reductions of cell viability after treatment of PBMC with 125 μ m gold sodium thiosulfate for 24 h (Rachmawati et al ., ). Our results further showed inhibitory effects of gold chloride on PBMC proliferation and IL‐2 release at sub‐toxic concentrations (100 μ m ), which could explain the immunosuppressive effect on lymphocyte proliferation.…”

Section: Discussionmentioning

confidence: 97%

Immunomodulatory effects of metal salts at sub‐toxic concentrations

Steinborn

Diegel

Garcia-Käufer

et al. 2016

J of Applied Toxicology

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Because different metals are used in complementary medicine for the treatment of diseases related to a dysfunction of the immune system, this study aimed at determining the immunomodulatory potential of Pb(NO ) , AuCl , Cu(NO ) , HgCl , AgNO , SnCl , AsCl and SbCl at sub-toxic concentrations and at assessing possible toxic side effects of low-concentrated metal preparations. The influence of the metal salts on primary human mononuclear cells was analyzed by measuring cell viability using the water-soluble tetrazolium salt assay, apoptosis and necrosis induction by annexin V/propidium iodide staining and proliferation by carboxyfluorescein diacetate succinimidyl ester staining and flow cytometry. Effects on T-cell activation were assessed with CD69 and CD25 expression using flow cytometry whereas CD83, CD86 and CD14 expression was measured to evaluate the influence on dendritic cell maturation. Alterations of interleukin-2 and interferon-γ secretion were detected by enzyme-linked immunosorbent assay and genotoxic effects were analyzed using the comet assay. At sub-toxic concentrations retardation of T-cell proliferation was caused by Pb(NO ) , AuCl and Cu(NO ) and inhibitory effects on interleukin-2 secretion were measured after incubation with Pb(NO ) , AuCl , Cu(NO ) , HgCl and AsCl Cu(NO ) had immunosuppressive activity at dosages within the serum reference range for copper. All other metal salts showed effects at dosages above upper serum limits of normal. Therefore, only low-concentrated copper preparations are promising to have immunomodulatory potential. Toxic side effects of metal preparations used in complementary medicine are improbable because upper limits of metals set in the drinking water ordinance are either not exceeded or the duration of their application is limited. Copyright © 2016 John Wiley & Sons, Ltd.

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Innate stimulatory capacity of high molecular weight transition metals Au (gold) and Hg (mercury)

Cited by 19 publications

References 28 publications

Materials design at the interface of nanoparticles and innate immunity

Materials design at the interface of nanoparticles and innate immunity

Recent Advances of Gold Compounds in Anticancer Immunity

Immunomodulatory effects of metal salts at sub‐toxic concentrations

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