Inner-ear abnormalities and their functional consequences in Belgian Waterslager canaries (Serinus canarius)

Gleich, Otto; Dooling, Robert J.; Manley, Geoffrey A.

doi:10.1016/0378-5955(94)90134-1

Cited by 32 publications

(31 citation statements)

References 37 publications

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“…Inner ear defects have been described for many mutant or inbred strains of animals including fish (e.g., Whitfield et al 1996;Malicki et al 1996;Riley and Grunwald 1996;Riley et al 1997), birds (e.g., Ballarino and Howland 1986;Gleich et al 1994aGleich et al , b, 1995Weisleder and Park 1994;Weisleder et al 1996;Jones et al 1998), and mammals (e.g., Ruben et al 1991;Lyon et al 1996;Zheng et al 1999;Morton 2002;Steel et al 2002). Among mammalian species, the mouse has a long history as a genetic model for hearing and/or balance dysfunction (e.g., Yerkes 1907; Lord and Gates 1929;Lyon 1953;Deol 1954;see also Ruben 1991;Henry and McGinn 1992;Brown 1994, 1996;Steel 1995;Lyon et al 1996;Morton 2002;Parkinson and Brown 2002;Avraham 2003).…”

Section: Introductionmentioning

confidence: 99%

A Quantitative Survey of Gravity Receptor Function in Mutant Mouse Strains

Jones

Johnson

et al. 2005

JARO

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The purpose of this research was to identify vestibular deficits in mice using linear vestibular evoked potentials (VsEPs). VsEP thresholds, peak latencies, and peak amplitudes from 24 strains with known genetic mutations and 6 inbred background strains were analyzed and descriptive statistics generated for each strain. Response parameters from mutant homozygotes were compared with heterozygote and/or background controls and all strain averages were contrasted to normative ranges. Homozygotes of the following recessive mutations had absent VsEPs at the ages tested: Espn je , Atp2b2 dfw-2J , Spnb4 qv-lnd2J , Spnb4 qv-3J , Myo7a sh1 , Tmie sr , Myo6 sv , jc, Pcdh15 av-J , Pcdh15 av-2J , Pcdh15 av-3J , Cdh23 v-2J , Sans js , hr, Kcne1 pkr , and Pou3f4 del . These results suggest profound gravity receptor deficits for these homozygotes, which is consistent with the structural deficits that have been documented for many of these strains. Homozygotes of Catna2 cdf , Grid2 ho4J , Wnt1 sw , qk, and Mbp shi strains and heterozygotes of Grid2 lc had measurable VsEPs but one or more response parameters differed from the respective control group (heterozygote or background strain) or were outside normal ranges. For example, qk and Mbp shi homozygotes showed significantly prolonged latencies consistent with the abnormal myelin that has been described for these strains. Prolonged latencies may suggest deficits in neural conduction; elevated thresholds suggest reduced sensitivity, and reduced amplitudes may be suggestive for reduced neural synchrony. One mutation, Otx1 jv , had all VsEP response parameters within normal limits-an expected finding because the abnormality in Otx1 jv is presumably restricted to the lateral semicircular canal. Interestingly, some heterozygote groups also showed abnormalities in one or more VsEP response parameters, suggesting that vestibular dysfunction, although less severe, may be present in some heterozygous animals.

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Section: Introductionmentioning

confidence: 99%

A Quantitative Survey of Gravity Receptor Function in Mutant Mouse Strains

Jones

Johnson

et al. 2005

JARO

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“…To determine whether this hearing loss occurred at a peripheral (e.g., cochlear) or a more central level, we recently investigated the basilar papillae of BWS canaries and quantitatively characterized hair cell pathologies and associated physiological deficits that are correlated with this hearing loss (Gleich et al, 1994aGleich and Dooling, 1995). Our scanning electron microscopic (SEM) investigations of the basilar papilla in BWS revealed that they have, on average, 30% fewer hair cells than do canaries of other strains (Gleich et al, 1994a).…”

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Evidence for supporting cell proliferation and hair cell differentiation in the basilar papilla of adult Belgian Waterslager canaries (Serinus canarius)

1997

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We used the bromodeoxyuridine technique to study the proliferative activity in the basilar papilla of normal and Belgian Waterslager canaries with and without preceding sound trauma. Without sound trauma, there were, on average, six supporting cell divisions per day in the basilar papilla of Waterslager canaries. This rate of supporting cell proliferation corresponds well with estimates of the rate of hair cell differentiation derived from counts of immature-appearing hair cells obtained by using scanning electron microscopy of the Waterslager basilar papilla. Thus, supporting cell division appeared correlated with hair cell differentiation in Waterslager canaries. Bromodeoxyuridine labeling of cells in undamaged non-Waterslager canaries also indicated a very low rate of supporting cell division. In contrast with Waterslager canaries, this low rate of proliferation was not associated with a measurable rate of hair cell differentiation. In both normal and Waterslager canaries, exposure to traumatizing sound induced a dramatic increase in the rate of cell proliferation. These data show that a very low rate of supporting cell proliferation is normally present in birds, but it is not associated with a corresponding rate differentiation of hair cells. Only an increase above this low ambient rate of supporting cell proliferation, such as that following loss of hair cells, induces the differentiation of new hair cells in birds. The reason why Waterslager canaries do not completely compensate for their inherited hair cell deficit of 30% is not clear, when they can clearly respond to additional cochlear trauma from noise exposure with an increase in proliferation rate.

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“…Male BWC normally learn their songs from their fathers and male siblings, though they can learn from other sources of acoustic input ͑Marler and Waser and Marler, 1977͒. Recent work has shown that song learning by juvenile BWC is largely influenced by tutor song, and that young birds are capable of imitating synthesized song with a structure that does not resemble normal adult song, highlighting the substantial influence of acoustic input during song learning ͑Gardner et al, 2005͒. BWC have been found to have a hereditary hearing loss, primarily above 2000 Hz, linked to hair cell abnormalities ͑Gleich et al, 1994͑Gleich et al, , 1995Dooling, 1985, 1987;Wright et al, 2004͒, which is presumably due to breeding for special song characteristics. Many hair cells are missing or damaged, and many of the remaining hair cells have abnormal stereocilia bundles ͑Gle-ich et Weisleder and Park, 1994;Weisleder et al, 1996͒.…”

Section: Introductionmentioning

confidence: 99%

Detection and discrimination of simple and complex sounds by hearing-impaired Belgian Waterslager canaries

Lauer

Dooling

Leek

et al. 2007

The Journal of the Acoustical Society of America

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Dooling, R. J.; Leek, M.R., Leek, M.R.; and Poling, K., "Detection and discrimination of simple and complex sounds by hearing-impaired Belgian Waterslager canaries" (2007). Journal of the Acoustical Society of America, 122, 6,[3615][3616][3617][3618][3619][3620][3621][3622][3623][3624][3625][3626][3627] Belgian Waterslager canaries ͑BWC͒ are bred to produce a distinctive low-pitched song with energy restricted to a lower range of frequencies than in other types of canaries. Previous studies have shown a high frequency hearing loss primarily above 2000 Hz that is related to hair cell abnormalities in BWC, but little is known about auditory perception in these birds. Here, frequency, duration, and intensity discrimination, temporal integration, gap detection, and discrimination of temporally reversed harmonic complexes in BWC were measured and compared to normal-hearing non-BWC. BWC had excellent frequency discrimination ability at 1000 Hz, but showed poor frequency discrimination compared to non-BWC at frequencies in the region of hearing loss. Duration and intensity discrimination were not adversely affected in BWC. Temporal integration was reduced in BWC, except at 2000 Hz. Gap detection and discrimination of temporally reversed stimuli were somewhat better in BWC than in non-BWC. Those tests that relied primarily on temporal processing were less affected by the cochlear damage in BWC than tests that probably relied more on audibility and spectral analysis. Thus, despite significant high frequency hearing loss and extensive damage along the basilar papilla, BWC retain relatively good hearing abilities under many conditions.

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Inner-ear abnormalities and their functional consequences in Belgian Waterslager canaries (Serinus canarius)

Cited by 32 publications

References 37 publications

A Quantitative Survey of Gravity Receptor Function in Mutant Mouse Strains

A Quantitative Survey of Gravity Receptor Function in Mutant Mouse Strains

Evidence for supporting cell proliferation and hair cell differentiation in the basilar papilla of adult Belgian Waterslager canaries (Serinus canarius)

Detection and discrimination of simple and complex sounds by hearing-impaired Belgian Waterslager canaries

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