Topicality. Today, one of the most important unresolved issues of the post-war recovery of Ukraine's economy is the strategic management of the economic development of socio-ecological-economic systems based on the effective use of resources to ensure their economic self-sufficiency, as well as the issue of realizing the potential of the entrepreneurial sector in a spatial and sectoral dimension, in the context of the fulfillment by entrepreneurs of their institutional roles – drivers of economic growth, use and reproduction of capital in social production, improvement of welfare and employment of the population.Aim and tasks. The purpose of this scientific article is to develop a methodological toolkit for diagnosing the resource provision of economic self-sufficiency of the region as a dominant factor in the post-war recovery and modernization of entrepreneurship in Ukraine and to assess the effectiveness of its application.This goal made it possible to form the following tasks: to provide a categorical apparatus on which the toolkit for resource provision of the region's economic self-sufficiency is based; determine the principles that must be followed when forming a database for calculating integral indicators of resource provision; develop an algorithm for calculating the above-mentioned index; to reveal the economic burden of group and generalizing integral indices according to the proposed method; carry out a diagnosis of the resource provision of economic self-sufficiency of the regions of Ukraine and provide an illustrative example of the use of the obtained results for making management decisions on the example of the Odesa region.Materials and Methods. This study was carried out because of the use of methods of logical, monographic and content analysis, analysis of hierarchies, standardization (norming), integral and rating evaluation. The source of information is the data of such statistical collections of Ukraine as: "Regions of Ukraine", "Environment of Ukraine", "Statistical Yearbook of Ukraine", "Labor of Ukraine", "Activity of Entrepreneurs", Statistics of the external sector of Ukraine according to the methodology of the 6th publication of the "Management on the Balance of Payments and International Investment Position"; Public report of the Head of the State Forest Resources Agency of Ukraine for 2020.Research results. The article contains a methodical toolkit for diagnosing the resource provision of the region's economic self-sufficiency based on the application of integral indices, which are formed according to the principle of compliance with the structural factors of the regional economic system using a systemic and praxeological approach. This made it possible to build a database for determining the indicators of the level of resource provision of the economic self-sufficiency of the region, to develop a method of integral assessment of this level, the use of which makes it possible to determine the potential and real opportunities of the region in the context of resource provision of its economic self-sufficiency as dominant factors of the post-war revival and modernization of entrepreneurship, and to carry out a diagnosis of the resource ensuring economic self-sufficiency in the regions of Ukraine.Conclusion. The results of the diagnosis of the resource provision of economic self-sufficiency of the regions of Ukraine, obtained on the basis of the application of the methodological tools proposed in the article, can be used for practical use by local self-government bodies, subjects of the formation of territorial communities, bodies of the State Statistics Service of Ukraine, State regional administrations, the Ministry of Development of Communities and Territories of Ukraine, the Ukrainian Union of Industrialists and Entrepreneurs in the process of assessing the resource provision of economic self-sufficiency of the territories with the aim of further developing measures to substantiate the development of entrepreneurship as an institutional driver of the country's post-war recovery.This scientific article was prepared within the framework of the National Development Program 3.1.8.82/B "Institutional modernization of the business sector in the context of local self-government reform" (№ 0122U002365).