Innovative toxikologische Untersuchungsmethoden für Eisenoxidnanopartikel in der Nanomedizin

Janko, Christina; Pöttler, Marina; Matuszak, Jasmin; Unterweger, Harald; Hornung, Annkathrin; Friedrich, Ralf P.

doi:10.1002/cite.201600077

Cited by 2 publications

(1 citation statement)

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“…Extensive reliable toxicological studies are another essential prerequisite for successful translation into clinical applications. In particular, the interference of nanoparticles with numerous classical toxicological detection methods forces the use of alternative methods such as real-time label-free analyses, multiparameter staining for flow cytometry and fluorescence microscopy [ 644 , 645 , 646 ]. Moreover, the use of 2D cell culture is not sufficient for in vitro evaluation of particles, but should be extended with 3D cell culture and flow models before promising NPs can be evaluated in animal models [ 647 ].…”

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confidence: 99%

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

2021

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In recent years, many promising nanotechnological approaches to biomedical research have been developed in order to increase implementation of regenerative medicine and tissue engineering in clinical practice. In the meantime, the use of nanomaterials for the regeneration of diseased or injured tissues is considered advantageous in most areas of medicine. In particular, for the treatment of cardiovascular, osteochondral and neurological defects, but also for the recovery of functions of other organs such as kidney, liver, pancreas, bladder, urethra and for wound healing, nanomaterials are increasingly being developed that serve as scaffolds, mimic the extracellular matrix and promote adhesion or differentiation of cells. This review focuses on the latest developments in regenerative medicine, in which iron oxide nanoparticles (IONPs) play a crucial role for tissue engineering and cell therapy. IONPs are not only enabling the use of non-invasive observation methods to monitor the therapy, but can also accelerate and enhance regeneration, either thanks to their inherent magnetic properties or by functionalization with bioactive or therapeutic compounds, such as drugs, enzymes and growth factors. In addition, the presence of magnetic fields can direct IONP-labeled cells specifically to the site of action or induce cell differentiation into a specific cell type through mechanotransduction.

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