Inonotus obliquus aqueous extract prevents histopathological alterations in liver induced by environmental toxicant Microcystin

Ishfaq, Pir Mohammad; Shivani, Mishra; Ahmad, Zaved; Shovanlal, Gayen; Jain, S. K.; Swati, Tripathi; Mishra, Siddhartha

doi:10.1016/j.crphar.2022.100118

Cited by 16 publications

(9 citation statements)

References 57 publications

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“…Several studies have shown the antitumor effects of Chaga mushrooms against various cancers, including lung adenocarcinoma, breast cancer, liver carcinoma, and colorectal cancer 6 , 7 , 10 , 31 . Chaga mushroom extract inhibits the growth of breast cancer cells by inducing autophagy processes 6 .…”

Section: Discussionmentioning

confidence: 99%

Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism

Yeo,

Yun,

Shin

et al. 2024

Sci Rep

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Oral cancer stands as a prevalent maligancy worldwide; however, its therapeutic potential is limited by undesired effects and complications. As a medicinal edible fungus, Chaga mushroom (Inonotus obliquus) exhibits anticancer effects across diverse cancers. Yet, the precise mechanisms underlying its efficacy remain unclear. We explored the detailed mechanisms underlying the anticancer action of Chaga mushroom extract in oral cancer cells (HSC-4). Following treatment with Chaga mushroom extracts, we analyzed cell viability, proliferation capacity, glycolysis, mitochondrial respiration, and apoptosis. Our findings revealed that the extract reduced cell viability and proliferation of HSC-4 cells while arresting their cell cycle via suppression of STAT3 activity. Regarding energy metabolism, Chaga mushroom extract inhibited glycolysis and mitochondrial membrane potential in HSC-4 cells, thereby triggering autophagy-mediated apoptotic cell death through activation of the p38 MAPK and NF-κB signaling pathways. Our results indicate that Chaga mushroom extract impedes oral cancer cell progression, by inhibiting cell cycle and proliferation, suppressing cancer cell energy metabolism, and promoting autophagy-mediated apoptotic cell death. These findings suggest that this extract is a promising supplementary medicine for the treatment of patients with oral cancer.

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Section: Discussionmentioning

confidence: 99%

Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism

Yeo,

Yun,

Shin

et al. 2024

Sci Rep

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“…For assaying the LPO, MDA concentration which is formed by the addition of thiobarbituric acid (TBA) as described previously. [26,[31][32][33] SOD activity was assessed in the brain regions by measuring the absorbance of formazan compound. CAT activity was assayed by the H 2 O 2 degradation kinetics, as well as GSH content and GR activity was assayed in the brain regions.…”

Section: Assay For No Lpo Sod Cat Reduced Gsh Grmentioning

confidence: 99%

Naringenin mitigates aluminum toxicity‐induced learning memory impairments and neurodegeneration through amelioration of oxidative stress

Rai,

Jat,

Mishra

2024

J Biochem & Molecular Tox

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Aluminum chloride (AlCl3) is a potent neurotoxic substance known to cause memory impairment and oxidative stress‐dependent neurodegeneration. Naringenin (NAR) is a dietary flavonoid with potent antioxidant and anti‐inflammatory properties which was implemented against AlCl3‐induced neurotoxicity to ascertain its neuroprotective efficacy. Experimental neurotoxicity in mice was induced by exposure of AlCl3 (10 mg/kg, p.o.) followed by treatment with NAR (10 mg/kg, p.o.) for a total of 63 days. Assessed the morphometric, learning memory dysfunction (novel object recognition, T‐ and Y‐maze tests), neuronal oxidative stress, and histopathological alteration in different regions of the brain, mainly cortex, hippocampus, thalamus, and cerebellum. AlCl3 significantly suppressed the spatial learning and memory power which were notably improved by administration of NAR. The levels of oxidative stress parameters nitric oxide, advanced oxidation of protein products, protein carbonylation, lipid peroxidation, superoxide dismutase, catalase, glutathione reductase, reduced glutathione, and the activity of acetylcholine esterase were altered 1.5–3 folds by AlCl3 significantly. Treatment of NAR remarkably restored the level of oxidative stress parameters and maintained the antioxidant defense system. AlCl3 suppressed the expression of neuronal proliferation marker NeuN that was restored by NAR treatment which may be a plausible mechanism. NAR showed therapeutic efficacy as a natural supplement against aluminum‐intoxicated memory impairments and histopathological alteration through a mechanism involving an antioxidant defense system and neuronal proliferation.

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“…The anti-inflammatory properties of Chaga associated with isolated ergosterol, ergosterol peroxide, and trametenolic acid were further confirmed by Kou et al (2021) . Ishfaq et al (2022) , demonstrated that aqueous extract of chaga possess anti-inflammatory chaacteristics. The study further demonstrated the ability of the extract to suppress expression of p53, caspace-3 and microcystin-LR known to cause inflammation and toxicity to the liver in mice ( Ishfaq et al, 2022 ).…”

Section: Pharmacological Potentialmentioning

confidence: 99%

Chaga mushroom: a super-fungus with countless facets and untapped potential

Fordjour,

Manful,

Javed

et al. 2023

Front. Pharmacol.

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Inonotus obliquus (Chaga mushroom) is an inexpensive fungus with a broad range of traditional and medicinal applications. These applications include therapy for breast, cervix, and skin cancers, as well as treating diabetes. However, its benefits are virtually untapped due to a limited understanding of its mycochemical composition and bioactivities. In this article, we explore the ethnobotany, mycochemistry, pharmacology, traditional therapeutic, cosmetic, and prospective agricultural uses. The review establishes that several secondary metabolites, such as steroids, terpenoids, and other compounds exist in chaga. Findings on its bioactivity have demonstrated its ability as an antioxidant, anti-inflammatory, antiviral, and antitumor agent. The study also demonstrates that Chaga powder has a long history of traditional use for medicinal purposes, pipe smoking rituals, and mystical future forecasts. The study further reveals that the applications of Chaga powder can be extended to industries such as pharmaceuticals, food, cosmetics, and agriculture. However numerous publications focused on the pharmaceutical benefits of Chaga with few publications on other applications. Overall, chaga is a promising natural resource with a wide range of potential applications and therefore the diverse array of therapeutic compounds makes it an attractive candidate for various applications such as plant biofertilizers and active ingredients in cosmetics and pharmaceutical products. Thus, further exploration of Chaga’s potential benefits in agriculture and other industries could lead to exciting new developments and innovations.

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Inonotus obliquus aqueous extract prevents histopathological alterations in liver induced by environmental toxicant Microcystin

Cited by 16 publications

References 57 publications

Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism

Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism

Naringenin mitigates aluminum toxicity‐induced learning memory impairments and neurodegeneration through amelioration of oxidative stress

Chaga mushroom: a super-fungus with countless facets and untapped potential

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