Inorganic nanoparticles for optical bioimaging

Jaque, Daniel; Richard, Cyrille; Viana, Bruno; Soga, Kohei; Liu, Xiaogang; Solé, J. Garcı́a

doi:10.1364/aop.8.000001

Cited by 183 publications

(110 citation statements)

References 355 publications

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“…After excitation, traps release the stored energy by thermal activation to emissive centers, which then emit light. PerL is also known as afterglow and is a phenomenon whereby luminescence lasts for minutes, hours, or even days . PerL possesses unique features such as possibility of excitation before injection and long duration of luminescence that result in high‐contrast, autofluorescence‐free optical imaging.…”

Section: Nanoparticles For In Vivo Bioimaging and Theranosticsmentioning

confidence: 99%

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Zhou

Leaño

Liu³

et al. 2018

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145

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Half a century after its initial emergence, lanthanide photonics is facing a profound remodeling induced by the upsurge of nanomaterials. Lanthanide-doped nanomaterials hold promise for bioapplications and photonic devices because they ally the unmatched advantages of lanthanide photophysical properties with those arising from large surface-to-volume ratios and quantum confinement that are typical of nanoobjects. Cutting-edge technologies and devices have recently arisen from this association and are in turn promoting nanophotonic materials as essential tools for a deeper understanding of biological mechanisms and related medical diagnosis and therapy, and as crucial building blocks for next-generation photonic devices. Here, the recent progress in the development of nanomaterials, nanotechnologies, and nanodevices for clinical uses and commercial exploitation is reviewed. The candidate nanomaterials with mature synthesis protocols and compelling optical uniqueness are surveyed. The specific fields that are directly driven by lanthanide doped nanomaterials are emphasized, spanning from in vivo imaging and theranostics, micro-/nanoscopic techniques, point-of-care medical testing, forensic fingerprints detection, to micro-LED devices.

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Section: Nanoparticles For In Vivo Bioimaging and Theranosticsmentioning

confidence: 99%

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Zhou

Leaño

Liu³

et al. 2018

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145

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“…Persistent luminescence materials made with particular centers emitting in the red and near infrared range have recently emerged as new powerful nanoprobes for bioimaging 31, 32, 33, 34. The main requirements that the materials must fulfill for this particular application are the following:

have size ranging from 50 to 200 nm.

…”

Section: Introductionmentioning

confidence: 99%

Chemically engineered persistent luminescence nanoprobes for bioimaging

L’Ecuyer¹,

Teston²,

et al. 2016

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Imaging nanoprobes are a group of nanosized agents developed for providing improved contrast for bioimaging. Among various imaging probes, optical sensors capable of following biological events or progresses at the cellular and molecular levels are actually actively developed for early detection, accurate diagnosis, and monitoring of the treatment of diseases. The optical activities of nanoprobes can be tuned on demand by chemists by engineering their composition, size and surface nature. This review will focus on researches devoted to the conception of nanoprobes with particular optical properties, called persistent luminescence, and their use as new powerful bioimaging agents in preclinical assays.

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“…1,2 Most of the currently used fluorescent probes have several drawbacks, such as low body penetration and high phototoxicity, because they are excited by ultraviolet (UV; o400 nm) or short wavelength visible (VIS; 400-700 nm) light. As an alternative, NIR light solves these problems and provides a new opportunity to observe deep parts of the body with low phototoxicity.…”

Section: Introductionmentioning

confidence: 99%