Over-1000 nm near-infrared fluorescent biodegradable polymer nanoparticles for deep tissue in vivo imaging in the second biological window

Kamimura, Masao; Takahiro, Shoko; Yoshida, Moe; Hashimoto, Yusuke; Fukushima, Rihito; Soga, Kohei

doi:10.1038/pj.2017.59

Cited by 46 publications

(45 citation statements)

References 21 publications

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“…Nanotechnology has offered investigators novel materials and tools against challenging problems that have remained unresolved for decades. Indeed, nanotechnology has allowed in vivo deep tissue imaging 1 – 3 , single photon emission tomography (SPECT)/computed tomography (CT) in vivo dual-modal imaging 4 , safe and controlled drug delivery 5 , and near-infrared (NIR)-induced photodynamic therapy 6 . In addition, nanotechnology has also enabled thermal therapy techniques such as photothermal therapy (PTT) 7 – 9 , making preeminent contributions to clinical studies.…”

Section: Introductionmentioning

confidence: 99%

Temperature Sensing of Deep Abdominal Region in Mice by Using Over-1000 nm Near-Infrared Luminescence of Rare-Earth-Doped NaYF4 Nanothermometer

Sekiyama

Umezawa

Kuraoka

et al. 2018

Sci Rep

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Luminescence nanothermometry has attracted much attention as a non-contact thermal sensing technique. However, it is not widely explored for in vivo applications owing to the low transparency of tissues for the light to be used. In this study, we performed biological temperature sensing in deep tissues using β-NaYF4 nanoparticles co-doped with Yb3+, Ho3+, and Er3+ (NaYF4: Yb3+, Ho3+, Er3+ NPs), which displayed two emission peaks at 1150 nm (Ho3+) and 1550 nm (Er3+) in the >1000 nm near-infrared wavelength region, where the scattering and absorption of light by biological tissues are at the minimum. The change in the luminescence intensity ratio of the emission peaks of Ho3+ and Er3+ (IHo/IEr) in the NaYF4: Yb3+, Ho3+, Er3+ nanothermometer differs corresponding to the thickness of the tissue. Therefore, the relationship between IHo/IEr ratio and temperature needs to be calibrated by the depth of the nanothermometer. The temperature-dependent change in the IHo/IEr was evident at the peritoneal cavity level, which is deeper than the subcutaneous tissue level. The designed experimental system for temperature imaging will open the window to novel luminescent nanothermometers for in vivo deep tissue temperature sensing.

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Section: Introductionmentioning

confidence: 99%

Temperature Sensing of Deep Abdominal Region in Mice by Using Over-1000 nm Near-Infrared Luminescence of Rare-Earth-Doped NaYF4 Nanothermometer

Sekiyama

Umezawa

Kuraoka

et al. 2018

Sci Rep

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“…The NIR‐II emission of NIR‐I dyes could be important to further improve fluorescence‐guided surgery with significantly reduced tissue autofluorescence and scattering, and the systematic investigation of bioconjugatable NIR‐I/II dyes will further enrich this field. Although optically guided surgery has been achieved in the NIR‐I region with several successful surgical navigation systems, it is still critically important to further improve the detection depth, signal contrast, and sensitivity . This improvement will yield a comprehensive fluorescence‐guided platform with adjustable imaging speed (real‐time) and contrast (S/B ratio), and multitargeted imaging for visualizing complex diseases simultaneously.…”

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confidence: 99%

Repurposing Cyanine NIR‐I Dyes Accelerates Clinical Translation of Near‐Infrared‐II (NIR‐II) Bioimaging

et al. 2018

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The significantly reduced tissue autofluorescence and scattering in the NIR-II region (1000-1700 nm) opens many exciting avenues for detailed investigation of biological processes in vivo. However, the existing NIR-II fluorescent agents, including many molecular dyes and inorganic nanomaterials, are primarily focused on complicated synthesis routes and unknown immunogenic responses with limited potential for clinical translation. Herein, the >1000 nm tail emission of conventional biocompatible NIR cyanine dyes with emission peaks at 700-900 nm is systematically investigated, and a type of bright dye for NIR-II imaging with high potential for accelerating clinical translation is identified. The asymmetry of the π domain in the S state of NIR cyanine dyes is proven to result in a twisted intramolecular charge-transfer process and NIR-II emission, establishing a general rule to guide future NIR-I/II fluorophore synthesis. The screened NIR dyes are identified to possess a bright emission tail in the NIR-II region along with high quantum yield, high molar-extinction coefficient, rapid fecal excretion, and functional groups amenable for bioconjugation. As a result, NIR cyanine dyes can be used for NIR-II imaging to afford superior contrast and real-time imaging of several biological models, facilitating the translation of NIR-II bioimaging to clinical theranostic applications.

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“…Previously, our group reported an easier method, the "onepot" procedure, for the preparation of OTN-NIR fluorescence PNPs (OTN-PNPs) by encapsulating a molecular dye, IR-1061, with an amphiphilic block copolymer containing the chain of poly(ethylene glycol) (PEG). 59 PNPs formed by self-assembly of block copolymers composed of PEG and hydrophobic segments have been used as carriers of drug delivery systems because it can encapsulate small molecules in the hydrophobic core. 64 Previous studies have investigated the in vivo behavior of PNPs encapsulating hydrophobic molecules as therapeutic drugs.…”

Section: Introductionmentioning

confidence: 99%

Effects of Processing pH on Emission Intensity of Over-1000 nm Near-Infrared Fluorescence of Dye-Loaded Polymer Micelle with Polystyrene Core

et al. 2020

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Over-1000 nm near-infrared fluorescent biodegradable polymer nanoparticles for deep tissue in vivo imaging in the second biological window

Cited by 46 publications

References 21 publications

Temperature Sensing of Deep Abdominal Region in Mice by Using Over-1000 nm Near-Infrared Luminescence of Rare-Earth-Doped NaYF4 Nanothermometer

Temperature Sensing of Deep Abdominal Region in Mice by Using Over-1000 nm Near-Infrared Luminescence of Rare-Earth-Doped NaYF4 Nanothermometer

Repurposing Cyanine NIR‐I Dyes Accelerates Clinical Translation of Near‐Infrared‐II (NIR‐II) Bioimaging

Effects of Processing pH on Emission Intensity of Over-1000 nm Near-Infrared Fluorescence of Dye-Loaded Polymer Micelle with Polystyrene Core

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