Inositol and vitamin D may naturally protect human reproduction and women undergoing assisted reproduction from Covid-19 risk

Espinola, Maria Salomé Bezerra; Bertelli, Matteo; Bizzarri, Mariano; Unfer, Vittorio; Laganà, Antonio Simone; Visconti, Berniero; Aragona, Cesare

doi:10.1016/j.jri.2021.103271

Cited by 18 publications

(16 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The COVID-19 pandemic has and will continue to impose substantial adversity on research and has limited clinical care for many gynecologic and fertility procedures [ 14 ]. Some suggestions specific to the IVF population have been made for alternative, low-cost treatments that may be protective against COVID infection [ 15 ]. COVID has already resulted in significant delays in clinical research recruitment [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Willingness of Women with Endometriosis Planning to Undergo IVF to Participate in a Randomized Clinical Trial and the Effects of the COVID-19 Pandemic on Potential Participation

et al. 2021

View full text Add to dashboard Cite

The Pre-IVF Treatment with a GnRH Antagonist in Women with Endometriosis (PREGnant) Trial (clinicaltrials.gov no. NCT04173169) was designed to test the hypothesis that 60-day pre-treatment with an oral GnRH antagonist in women with documented endometriosis and planning an IVF cycle will result in a superior live birth rate to placebo. Eight hundred fourteen women are required from 4 national sites. To determine the feasibility of using an electronic medical record (EMR)-based strategy to recruit 204 participants at the Colorado site, we conducted a survey of women within the UCHealth system. Eligible women, identified using relevant ICD-10 codes, were invited to complete a 6-question survey to assess planned utilization of IVF, potential interest in participation, and whether delays in treatment due to COVID-19 would influence their decision to participate. Of 6354 age-eligible women with an endometriosis diagnosis, 421 had a concurrent infertility diagnosis. After eliminating duplicates, 212 were emailed a survey; 76 (36%) responded, 6 of whom reported no endometriosis diagnosis. Of the remaining 70, 29 (41%) were planning fertility treatment; only 19 planned IVF. All 19 expressed interest in participation. COVID-19 delays in treatment were not considered as a factor affecting participation by 8/19; the remaining 11 felt that it would “somewhat” affect their decision. None reported that they would not consider participation because of COVID-19. EMR-based recruitment for an endometriosis clinical trial is feasible although the overall yield of participants is low. Delays in treatment due to COVID-19 did not appear to overly influence potential recruitment.

show abstract

Section: Discussionmentioning

confidence: 99%

Willingness of Women with Endometriosis Planning to Undergo IVF to Participate in a Randomized Clinical Trial and the Effects of the COVID-19 Pandemic on Potential Participation

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Similarly, vitamin D has also been proposed as a possible adjuvant for fertility. However, unlike the inositols, vitamin D excessive levels may play a detrimental role in infertility [121][122][123].…”

Section: The Missing Link: New Insights Into Fertility Outcomesmentioning

confidence: 99%

Impact of lifestyle and diet on endometriosis: a fresh look to a busy corner

Habib¹,

Buzzaccarini²,

Centini³

et al. 2022

View full text Add to dashboard Cite

Endometriosis is a chronic inflammatory disorder with a prevalence of six to ten percent in women of childbearing age. As long as the aetiology of endometriosis is not fully understood and the disease has no definitive treatment, an examination of the environmental factors or interventions that could modify or cure endometriosis would greatly benefit women suffering from this chronic condition. This literature review utilized the electronic databases PubMed, EMBASE, and MEDLINE until February 2021. Studies indicate that fish oil may have a positive effect on reducing endometriosis-related pain due to the effects of pro-inflammatory prostaglandins derived from omega-3 fatty acids. The same effect was seen with the introduction of antioxidant vitamins C, D, and E. There is clinical viability of a low fermentable oligo-, di-, and mono-saccharides and polyols diet to successfully reduce the symptoms of patients who suffer from both endometriosis and irritable bowel syndrome. Despite the low level of evidence, there are frequent associations between endometriosis and gastrointestinal conditions in addition to the influence of various nutritional factors on the disease. The management of endometriosis requires a holistic approach focused on reducing overall inflammation, increasing detoxification, and attenuating troublesome symptoms. A dietician may provide great benefit in the management of these patients, especially at younger ages and in early stages. High-level evidence and well-designed randomized studies are lacking when it comes to studying the effect of lifestyle and dietary intake on endometriosis. Inarguably, further research with a more extensive focus is needed.

show abstract

“…Calcium in extremely important for S100 protein expressed by immune cells, in particular macrophages, in immune response [161]. Vitamin D is related to a reduction in viral replication and viral infectivity [162,163]. Vitamin D in pregnant women has shown preventive effects against preeclampsia [164,165], and preterminal birth [166], playing a role in angiogenesis, placental implantation, and endothelial functions [167].…”

Section: Zinc (Zn)mentioning

confidence: 99%

Immune System and Psychological State of Pregnant Women during COVID-19 Pandemic: Are Micronutrients Able to Support Pregnancy?

et al. 2022

View full text Add to dashboard Cite

The immune system is highly dynamic and susceptible to many alterations throughout pregnancy. Since December 2019, a pandemic caused by coronavirus disease 19 (COVID-19) has swept the globe. To contain the spread of COVID-19, immediate measures such as quarantine and isolation were implemented. These containment measures have contributed to exacerbate situations of anxiety and stress, especially in pregnant women, who are already particularly anxious about their condition. Alterations in the psychological state of pregnant women are related to alterations in the immune system, which is more vulnerable under stress. COVID-19 could therefore find fertile soil in these individuals and risk more severe forms. Normally a controlled dietary regimen is followed during pregnancy, but the use of particular vitamins and micronutrients can help counteract depressive-anxiety states and stress, can improve the immune system, and provide an additional weapon in the defense against COVID-19 to bring the pregnancy to fruition. This review aims to gather data on the impact of COVID-19 on the immune system and psychological condition of pregnant women and to assess whether some micronutrients can improve their psychophysical symptoms.

show abstract

Inositol and vitamin D may naturally protect human reproduction and women undergoing assisted reproduction from Covid-19 risk

Cited by 18 publications

References 49 publications

Willingness of Women with Endometriosis Planning to Undergo IVF to Participate in a Randomized Clinical Trial and the Effects of the COVID-19 Pandemic on Potential Participation

Willingness of Women with Endometriosis Planning to Undergo IVF to Participate in a Randomized Clinical Trial and the Effects of the COVID-19 Pandemic on Potential Participation

Impact of lifestyle and diet on endometriosis: a fresh look to a busy corner

Immune System and Psychological State of Pregnant Women during COVID-19 Pandemic: Are Micronutrients Able to Support Pregnancy?

Contact Info

Product

Resources

About