Insertion/deletion polymorphism of the bradykinin type 2 receptor gene influence diastolic blood pressure

Gender-related associations of genetic polymorphisms of α-adrenergic receptors, endothelial nitric oxide synthase and bradykinin B2 receptor with treadmill exercise test responses

“…This polymorphism was associated with autonomic control and with blood pressure responses to antihypertensive drugs. 29–31 In a multiethnic Brazilian study with 1500 participants, the rs1048101 allele Cys was associated with higher levels of blood pressure in a subgroup of physically active participants aged 45 years or lower, but not in sedentary participants, 32 suggesting that this variant may be implicated with the blood pressure adaptations to exercise.…”

“…In a Brazilian study, the deletion allele was associated with higher diastolic blood pressure in the general population of a metropolitan area. 32 Another BDKRB2 polymorphism has been shown to influence physical performance in marathon runners. 46 These findings suggest that BDKRB2 may participate in the modulation of exercise.…”

The correlation between SNPs within the gene of adrenergic receptor and neuropeptide Y and risk of cervical vertigo

“…Among the investigated SNPs of ADRA1A , rs1048101 was located in the 4th exon of ADRA1A , and the mutation of C to T belonged to nonsynonymous mutation, suggesting that the mutation of bases could alter the sequences of the translated proteins and thereby to affect the function of proteins. Previously, a Brazilian study covering 1500 subjects of multiple ethnicities drawn a conclusion that rs1048101 could participate in altering the blood pressure of physically active populations . More than that, rs1048101 was also documented to display associations with the effects of antihypertensive drugs on the blood pressure .…”

“…Previously, a Brazilian study covering 1500 subjects of multiple ethnicities drawn a conclusion that rs1048101 could participate in altering the blood pressure of physically active populations. 22 More than that, rs1048101 was also documented to display associations with the effects of antihypertensive drugs on the blood pressure. [23][24][25] Thus, the correlation between rs1048101 and susceptibility to cervical vertigo was quite acceptable.…”

Resposta cardiovascular ao teste ergométrico e a capacidade vasodilatadora periférica quanto a polimorfismos genéticos da enzima sintetase do óxido nítrico endotelial e dos receptores alfa-adrenérgicos

“…O receptor B2 da bradicinina parece desempenhar um importante papel na regulação e modulação dos fenômenos biológicos associados à bradicinina [Burch et al 1992] O gene do receptor B2 da bradicinina é um candidato na modulação genética de doenças crônicas como hipertensão arterial sistêmica e doença isquêmica cardíaca, e variantes genéticas neste gene foram previamente identificadas [Braun et al, 1995, Freitas et al, 2009. Apesar de alguns estudos terem avaliado os polimorfismos associados ao gene do receptor B2 da bradicinina quanto à sua prevalência em determinadas populações [ZakrzewskiJakubiak et al, 2008], para nosso conhecimento atual, estas variantes não foram estudadas em relação à vasodilatação periférica ou ao exercício.…”