Insight into the Hypoglycaemic Effect of Traditional Indian Herbs used in the Treatment of Diabetes

Joseph, Baby; Jini, D.

doi:10.3923/rjmp.2011.352.376

Cited by 79 publications

(56 citation statements)

References 39 publications

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“…In fact, in many parts of the world, especially poor countries, this may be the only form of therapy available to treat diabetic patients. There are several reviews by different authors about anti-diabetic herbal plants [1,[14][15][16][17] . Ayurveda and other traditional medicinal systems for the treatment of diabetes describe a number of plants used as herbal drugs.…”

Section: Plant-based Anti-diabetic Medicinementioning

confidence: 99%

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Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency

Joseph¹,

Jini²

2013

Asian Pacific Journal of Tropical Disease

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387

252

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Section: Plant-based Anti-diabetic Medicinementioning

confidence: 99%

“…Diabetes mellitus is considered as one of the five leading causes of death in the world [1] . Diabetes mellitus is a major global health concerning with a projected rise in prevalence from 171 million in 2000 to 366 million in 2030 [2] .…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency

Joseph¹,

Jini²

2013

Asian Pacific Journal of Tropical Disease

Self Cite

387

252

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“…Diabetes is a serious metabolic disorder characterised by altered carbohydrate, lipid and protein metabolism which causes hyperglycemia resulting from insufficient insulin secretion, insulin action or both (Joseph, Jini, 2011).…”

Section: Introductionmentioning

confidence: 99%

Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetes

Haroon

Murali

2016

Braz. J. Pharm. Sci.

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Murva is an important drug in Ayurveda. Wattakaka volubilis is used as one of the botanical sources of Murva. The aim of this study is to evaluate the effect of the alcohol extract of W. volubilis root in streptoztocin (STZ) induced diabetes and diabetic neuropathy. Diabetes mellitus (DM) was induced by the administration of STZ (45 mg/kg, i.p). DM was induced within 72 h. Diabetic animals were treated with glimepiride (0.5 mg/kg) and ethyl alcohol extract 100 and 200 mg/kg for 21 d. After determining the changes in fasting serum glucose and lipid profile, animals were further treated for a period of 15 d to determine the protective effect of extract against diabetic neuropathy. All the alcohol extract treated animals, showed a significant decrease in serum glucose level (P<0.001), and overall decrease in the severity of diabetic neuropathy. Alcohol extract of W. volubilis root showed antihyperglycemic activity and beneficial protection against diabetic neuropathy and hence can be a promising agent for treatment and prevention of diabetic neuropathy.

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“…Furthermore, they are also able to target multiple mechanisms comprising of improvement in insulin sensitivity, stimulation of insulin secretion, or limitation of carbohydrate absorption. [4][5][6] According to VietHerb Ontology database, Catharanthus roseus (L.) G. Don (C. roseus), a herbaceous plant of family Apocynaceae, widely distributes all over the world, primarily tropical regions. C. roseus is a small medicinal plant of about 30 to 100 centimeters in height with glossy green leaves, rounded apex, fragrant-smelled flowers, follicle hair and many seeds.…”

mentioning

confidence: 99%

Exploring Anti-Hyperglycemic Potential of Alkaloid Compounds From Catharanthus Roseus G. Don (L) Against Various Type Ii Diabetes Targets by in Silico Virtual Screening

Le¹

2017

WJPPS

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Background: Catharanthus roseus (L.) G. Don (C. roseus) is a prominent anticancer herb having high alkaloid content. Besides known anticancer effect, this plant has been also traditionally used as an effective anti-diabetic treatment in many Asian countries, such as India, Malaysia, and Vietnam. Some in vivo and in vitro studies on its compounds and fractional extracts have confirmed its strong anti-hyperglycemia. This fact raises a question whether alkaloid compounds probably play any function in inhibitory activity on proteins related to Type 2 Diabetes Mellitus (T2DM). This study, therefore, was conducted not only to assess the role of alkaloid compounds in glucoregulatory pathway but also investigate other chemical groups treating T2DM besides known ones such as polyphenols and terpenoids. Ly et al. World Journal of Pharmacy and Pharmaceutical Sciencesprotein's active sites. Besides, pharmacokinetics of these compounds were also evaluate to support the conclusion of potent drug candidates for T2DM treatment. Method: Molecular Dynamics (MD) simulation was processed on pre-docking protein to assess the their stability.Then, the structure-based virtual screening was processed to evaluate the binding free energy of the alkaloid compounds when they were in contact with the protein active sites. Potent compounds whose binding free energy was greater than or equal to those of the control ligands were selected for pharmacophore analysis to investigate which functional residue got involve in the interaction. Besides, pharmacokinetics evaluation was done to assess the adverse drug interaction. All the in silico results were combined to explain and suggest potent compounds. Results: All structure of protein was simulated to assess the stability before processing structure-based virtual screening. After structure-based screening, 12 potential compounds were sellected. Then, pharmacokinetics of all compounds was evaluated. Enzyme CYP2C9 is considered to be the least targeted isoform while CYP2D6 is the most targeted one, followed by CYPA4. Structure-based pharmacophore features of these compounds were also analyzed to understand their molecular interaction modes and explain the differences in binding free energy. Conclusion: After combining all the in silico result, there were 8 compounds (com_05, com_07, com_16, com_26, com_27, com_28, com_46, and com_56) were suggested to be potent drug candidates for experimental confirmation. Besides, com_56(Strictosidine lactam) and com_46 (Mitraphyllline) are considered to be two best top-hit ligands with extremely high docked score. These ligands, however, well targeted on 11-β-HSD1. Moreover, since 4 in 8 compounds well targeted on 11-β-HSD1, this protein is undoubtly confirmed as the most suitable receptor for in vitro testing. On the other hand, although com_21 (Alstonine) was temporarily rejected due to targeting on up to 3 three CYP enzyme, the potential role of this compound should be carefully re-assess because it is the only multi-target compounds toward to 4 pr...

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Insight into the Hypoglycaemic Effect of Traditional Indian Herbs used in the Treatment of Diabetes

Cited by 79 publications

References 39 publications

Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency

Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency

Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetes

Exploring Anti-Hyperglycemic Potential of Alkaloid Compounds From Catharanthus Roseus G. Don (L) Against Various Type Ii Diabetes Targets by in Silico Virtual Screening

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