Insights into the separation performance of MOFs by high-performance liquid chromatography and in-depth modelling

Qin, Weiwei; Silvestre, Martin E.; Brenner‐Weiß, Gerald; Wang, Zhengbang; Schmitt, Sophia; Hübner, Jonas; Franzreb, Matthias

doi:10.1016/j.seppur.2015.10.008

Cited by 18 publications

(4 citation statements)

References 35 publications

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“…In addition, referring to the preparative chromatography for SGs separation [12, 46‐47], HP‐NH 2 ‐MIL‐53 has the general conditions of chromatographic filler: high specific surface area, high porosity and stability, appropriate particle size, with amino group and reveals reversed‐phase mode retention properties (the column used for the analytical HPLC is an amine column). Moreover, according to the currently reported literature on MOF as chromatographic column filler [48–50], most MOF‐based materials can modify the stationary phase as preparative chromatography such as MOF@SiO 2 core‐shell stationary phase [49]. Therefore, in addition to being directly used for adsorption and separation, HP‐NH 2 ‐MIL‐53 has the potential to be used as a stationary phase or an auxiliary stationary phase to realize the separation of natural products, especially SGs.…”

Section: Resultsmentioning

confidence: 99%

A well‐defined hierarchically porous metal–organic framework and its application in separation and purification of steviol glycosides

Chen

Huang

et al. 2022

J of Separation Science

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The separation and removal of stevioside from natural product steviol glycosides to obtain high-purity rebaudioside A is of great significance for the application of steviol glycosides in food, medicine, and other fields. Here, in order to explore the adsorbent pore structure suitable for the separation of stevioside and rebaudioside A, a hierarchically porous amino-functionalized metal-organic framework (HP-NH 2 -MIL-53) with an appropriate and narrow pore size distribution was prepared using a modulator-induced defect-formation strategy. The results showed that the hierarchically porous structure with micropores and mesopores increased the specific surface area and exposed amino groups compared with original metal organic framework (NH 2 -MIL-53), and the maximum adsorption capacity of HP-NH 2 -MIL-53 for stevioside and rebaudioside A was 233.89 mg/g. The narrow pore size distribution close to 3.80 nm promoted the screening effect, resulting in a maximum adsorption selectivity of 4.13. This work proves that when the pore size of the adsorbent is between 1.41 and 3.80 nm, it has a certain pore size screening effect on stevioside and rebaudioside A, and the hierarchically porous metal-organic frameworks provide a pre-design idea of adsorbent structure for the separation of natural products with molecular weight of 800-1000 Da.

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Section: Resultsmentioning

confidence: 99%

A well‐defined hierarchically porous metal–organic framework and its application in separation and purification of steviol glycosides

Chen

Huang

et al. 2022

J of Separation Science

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“…Qin et al. used the composite magnetic silica particles as scaffold for the synthesis of UiO‐67 (Zr) coating . The step‐by‐step coating was again utilised to achieve the desired coating.…”

Section: Fabrication Of Core–shell Particles For Separationsmentioning

confidence: 99%

“…Step-by-step assembly growth strategy using ethanolic solutions of metal source and ligand was used and desired shell thickness was achieved by repetitive deposition process. Qin et al used the composite magnetic silica particles as scaffold for the synthesis of UiO-67 (Zr) coating [120]. The step-bystep coating was again utilised to achieve the desired coating.…”

Section: Core-shell Particles With Silica-core and Mof-shellmentioning

confidence: 99%

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Core–shell microspheres with porous nanostructured shells for liquid chromatography

Ahmed

Skinley

Herodotou

et al. 2017

J of Separation Science

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The development of new stationary phases has been the key aspect for fast and efficient high-performance liquid chromatography separation with relatively low backpressure.Core-shell particles, with a solid core and porous shell, have been extensively investigated and commercially manufactured in the last decade. The excellent performance of core-shell particles columns has been recorded for a wide range of analytes, covering small and large molecules, neutral and ionic (acidic and basic), biomolecules and metabolites. In this review, we first introduce the advance and advantages of coreshell particles (or more widely known as superficially porous particles) against nonporous particles and fully porous particles. This is followed by the detailed description of various methods used to fabricate core-shell particles. We then discuss the applications of common silica core-shell particles (mostly commercially manufactured), spheres-on-sphere particles and core-shell particles with a non-silica shell. This review concludes with a summary and perspective on the development of stationary phase materials for high-performance liquid chromatography applications.

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The Rise of Metal–Organic Frameworks in Analytical Chemistry

Pacheco‐Fernández

González‐Hernández

Pasán

et al. 2019

Handbook of Smart Materials in Analytical Chemistry

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Insights into the separation performance of MOFs by high-performance liquid chromatography and in-depth modelling

Cited by 18 publications

References 35 publications

A well‐defined hierarchically porous metal–organic framework and its application in separation and purification of steviol glycosides

A well‐defined hierarchically porous metal–organic framework and its application in separation and purification of steviol glycosides

Core–shell microspheres with porous nanostructured shells for liquid chromatography

The Rise of Metal–Organic Frameworks in Analytical Chemistry

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