Insomnia in adults

Morin, Charles M.; Daley, Meagan; Ouellet, Marie‐Christine

doi:10.1007/s11940-001-0020-y

Cited by 11 publications

(3 citation statements)

References 31 publications

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“…63, 64 More severe sleep disorders occur at a frequency 2-3 times greater than the general population. 65, 66 In a recent study by Savard et al, 962 patients with non-metastatic cancer in the perioperative phase (T1) were studied and followed over 18 month period. 67 At T1, 31% had insomnia symptoms, defined as a complaint of sleep difficulties and need for hypnotic medication 1-2 night per week, while 28% had more severe insomnia syndrome.…”

Section: Additional Mechanisms Leading To Autonomic Dysfunction In Brmentioning

confidence: 99%

Autonomic dysfunction in early breast cancer: Incidence, clinical importance, and underlying mechanisms

Lakoski

Jones

Krone

et al. 2015

American Heart Journal

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Autonomic dysfunction represents a loss of normal autonomic control of the cardiovascular system associated with both sympathetic nervous system overdrive and reduced efficacy of the parasympathetic nervous system. Autonomic dysfunction is a strong predictor of future coronary heart disease, vascular disease and sudden cardiac death. In the current review, we will discuss the clinical importance of autonomic dysfunction as a cardiovascular risk marker among breast cancer patients. We will review the effects of antineoplastic therapy on autonomic function, as well as discuss secondary exposures, such as psychological stress, sleep disturbances, weight gain/ metabolic derangements, and loss of cardiorespiratory fitness which may negatively impact autonomic function in breast cancer patients. Lastly, we review potential strategies to improve autonomic function in this population. The perspective can help guide new therapeutic interventions to promote longevity and cardiovascular health among breast cancer survivors. Keywords autonomic dysfunction; cardiovascular disease; breast cancerCorrespondence: Susan G. Lakoski, MD, University of Vermont, Department of Internal Medicine, 208 South Park Drive Colchester, VT 05446, USA, susan.lakoski@uvm.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conflicts of Interest:Dr. Lee Jones is a cofounder a commercial company, Exercise by Science, Inc. DisclosureThe authors are solely responsible for the design and conduct of this study, all study analyses, the drafting and editing of the paper and its final contents. HHS Public AccessAuthor manuscript Am Heart J. Author manuscript; available in PMC 2016 August 01. Author Manuscript Author Manuscript Author Manuscript Author ManuscriptDue to significant improvements in early detection and adjuvant therapy, early breast cancer patients are now expected to live long enough to be at risk for competing causes of death. 1 Cardiovascular disease (CVD) is rapidly becoming the predominant cause of mortality in breast cancer survivors over 60 years of age. 2 The magnitude of this problem is likely to increase with the aging of the US population, improvements in breast cancer-specific survival, and the continued use of antineoplastic agents with cardiovascular toxicities. Thus, given the nearly 3 million breast cancer survivors in the US, the number of women at excess risk for CVD is likely to increase dramatically over the next two decades, requiring specific strategies to predict and mitigate these risks.Adjuvant therapies used in the current treatment of early breast cancer are associa...

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Section: Additional Mechanisms Leading To Autonomic Dysfunction In Brmentioning

confidence: 99%

Autonomic dysfunction in early breast cancer: Incidence, clinical importance, and underlying mechanisms

Lakoski

Jones

Krone

et al. 2015

American Heart Journal

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“…They could be an independent clinical disorder or a symptom of a clinical syndrome. They usually have direct and indirect effects on the daily functioning and quality of life of sufferer and could lead to significant healthcare costs for the society [2], [3], [4], [5]. Each year they affect many individuals and cause intrapersonal and interpersonal impairments [6].…”

Section: Introductionmentioning

confidence: 99%

Does abstinence resolve poor sleep quality in former methamphetamine dependents?

et al. 2016

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Background and objectiveAmong substances that have a significant effect on sleep are stimulants, including amphetamines. As there are few studies assessing sleep quality in methamphetamine withdrawal this study aims to evaluate changes in sleep quality of methamphetamine dependent patients during early remission period by controlling depression and anxiety as confounding variables.MethodsThis study was conducted in Mashhad, Iran. Ninety amphetamine dependent patients, who were admitted in residential centers during 2012–2014 and met our inclusion criteria, were chosen by purposive nonprobability sampling method. Sleep quality was assessed by Pittsburg sleep questionnaire, in the first, second, and after the fourth week of abstinence. Additionally all participants were assessed by Beck Depression Inventory-2 and Beck Anxiety Inventory for controlling depressive and anxiety symptoms.ResultsThe prevalence of improper quality of sleep was very high (97.8%) within the first week of withdrawal, but it reduced considerably four weeks after abstinence (52.2%), which was statistically significant (P=0.00). The variations of depression and anxiety levels within four weeks after quitting methamphetamine, have low impact on variation of patients' sleep quality (adjusted R2<0.5). Furthermore, the effectiveness of these two intervening variables on patients' quality of sleep was dwindled over time after abstinence.ConclusionsThis study showed that the patients' quality of sleep improved significantly four weeks after abstinence and its variation was independent from variations in anxiety and depressive symptoms.

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“…1 Despite the availability of effective behavioral treatments for insomnia, pharmacotherapy remains the most widely used treatment method. 2 Benzodiazepine-receptor agonists are the most frequently prescribed drugs for insomnia, and, despite the advent of new nonbenzodiazepine agents (zolpidem, zaleplon, zopiclone), traditional benzodiazepines (BZ) are still widely prescribed for sleep. Although BZ can be indicated and effective for the short-term management of insomnia, 3 most patients for whom a hypnotic is prescribed, particularly older adults, continue using it for prolonged periods.…”

Section: Introductionmentioning

confidence: 99%

Sleep EEG Power Spectra, Insomnia, and Chronic Use of Benzodiazepines

Bastien¹,

LeBlanc²,

Carrier³

et al. 2003

Sleep

Self Cite

148

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The findings show that spectral analysis is an efficient tool to detect and quantify the effects of benzodiazepine use on sleep structure, particularly with older adults, a group for whom macrostructure sleep alterations due to physiologic aging are hard to distinguish from sleep changes induced by insomnia and the use of hypnotic drugs. In addition, these results raise important questions about the effects and indications of prolonged use of benzodiazepine medications in older adults with insomnia complaints.

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Insomnia in adults

Cited by 11 publications

References 31 publications

Autonomic dysfunction in early breast cancer: Incidence, clinical importance, and underlying mechanisms

Autonomic dysfunction in early breast cancer: Incidence, clinical importance, and underlying mechanisms

Does abstinence resolve poor sleep quality in former methamphetamine dependents?

Sleep EEG Power Spectra, Insomnia, and Chronic Use of Benzodiazepines

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