Insulin dependant diabetes mellitus: implications for male reproductive function

Agbaje, Ishola; Rogers, Deirdre; McVicar, Carmel; McClure, Neil; Atkinson, A. B.; Mallidis, Con; Lewis, Sheena

doi:10.1093/humrep/dem077

Cited by 440 publications

(356 citation statements)

References 89 publications

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“…Pathophysiological dysfunctions in diabetes is associated with oxidative stress which is likely to contribute abnormalities in sperm nuclear DNA. The earlier study has reported an increase in sperm nuclear abnormalities in diabetic patients [2]. Since human studies have ethical and technical limitations to find an exact relationship between blood glucose level and sperm chromatin integrity, we assessed sperm DNA damage in controlled hyperglycemic condition for a period two spermatogenesis cycles and then correlated with blood glucose level.…”

Section: Discussionmentioning

confidence: 99%

“…Earlier studies have shown that patients with DM have diminished sperm quality which is possibly due to endocrine dysfunction as the alteration in testosterone level in DM is associated with steroidogenic defect in Leydig cells [1][2][3]. In addition, it has been shown that diabetic men have a significantly higher percentage of spermatozoa with nuclear DNA damage [2] possibly due to oxidative stress. Sperm DNA integrity is essential for accurate transmission of genetic information to the offspring.…”

Section: Introductionmentioning

confidence: 99%

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Germ cell abnormalities in streptozotocin induced diabetic mice do not correlate with blood glucose level

Bose

Adiga

D’Souza

et al. 2012

J Assist Reprod Genet

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Purpose To assess the effect of streptozotocin induced hyperglycemia on germ cell integrity, DNA ploidy and methylation status for a period of two spermatogenesis cycles in adult male Swiss albino mice. Methods Streptozotocin injected mice were monitored for hyperglycemia at a regular interval for a period of 36 and 72 days. The DNA integrity in epididymal spermatozoa was determined by the comet assay. Flow cytometric analysis was done in germ cells to assess the DNA ploidy. The global methylation analysis in germ cells was done by 5-methyl cytosine immunostaining.Results Streptozotocin administration successfully resulted in hyperglycemic response which significantly affected serum testosterone level, sperm DNA integrity and DNA ploidy at the end of 36 days. However, no changes were observed in either epididymal sperm concentration or germ cell methylation status. In contrast, at the end of 76 days, although serum testosterone level, sperm DNA integrity and DNA ploidy status were unperturbed significantly in hyperglycemic group, the epididymal sperm concentration and methylation status of preleptotene/zygotene cells were significantly altered. Importantly, an attempt to find out the association between the blood glucose levels and the abnormalities in hyperglycemic group failed to demonstrate any correlation. Conclusions The germ cell abnormalities observed in hyperglycemic group could be interpreted as a primary effect of streptozotocin and not due to hyperglycemia. Our results call for further evaluation of streptozotocin before its application to study the hyperglycemic responses on male germ cells.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Germ cell abnormalities in streptozotocin induced diabetic mice do not correlate with blood glucose level

Bose

Adiga

D’Souza

et al. 2012

J Assist Reprod Genet

View full text Add to dashboard Cite

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“…Of these, translocation is most common chromosomal abnormality. A study showed that the frequency of chromosomal translocations was 2.1% in infertile men [46]. Chromosomal translocations can be of many typesRobertsonian translocation, reciprocal translocation and these account for 10% of the causes of male infertility [47].…”

Section: Molecular Insight Into Male Infertilitymentioning

confidence: 99%

Male Infertility; Evidences, Risk Factors, Causes, Diagnosis and Management in Human

Sharma¹

2017

Ann Clin Lab Res

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Infertility has become ominous problem. On an average, about 10% of all couples face difficulty in starting a family and this creates a feeling of great personal failure, particularly in India where religious and socio-economic traditions have made it almost imperative for everyone to have children. A significant association had been found between impaired semen quality including sperm count, motility and morphology. In this review, the various contributory etiological factors i.e., exposure to heavy metals, pesticides, industrial chemicals, endocrine factors, genetics causes and modern life style had been discussed which have a serious impact on male infertility. In this article we analyzed data from different sources and present evidences of the possible etiology and risk factors for male infertility. There is a need to emerge at the indiscriminate use and disposal of environmental chemicals. Especially pesticides and industrial chemicals as the chemicals enter the food chain, surface and ground water which had potential for exposure during the critical period of development further avoiding tobacco smoking, excessive alcoholism, excessive heat exposure to the testes can help in improving the semen quality.

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“…Vignon et al (1990) have previous reported a significant increase in sperm concentration in TIDM patients, while Garcia-Diez (1991) has reported a significant decrease in sperm count, motility and percentage of spermatozoa with normal morphology. However, Agbaje et al (2007) have found an insignificant increase in sperm concentration and total sperm output with an insignificant decrease in sperm motility, and normal sperm morphology. The authors suggested Leydig cell hyperplasia as the cause of the enhanced spermatogenesis, though with poor motility.…”

Section: Effect Of Diabetes Mellitus On Spermatogenesismentioning

confidence: 95%

Diabetes mellitus-induced male reproductive impairment: The role of natural products: A review

2017

J App Pharm Sci

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Diabetes mellitus (DM) is a metabolic disorder characterized by persistent hyperglycaemia, with multi-organ complications. DM is known to trigger oxidative stress in virtually all tissues of the body including male reproductive organs. Several experimental and clinical studies have reported varying degrees of male reproductive impairment in DM. Disruption in the hypothalamic-pituitary-gonadal axis, abnormal testicular energy metabolism, testicular and epididymal oxidative stress and oxidative stress-induced germ cell apoptosis have been reported in DM. The use of natural products in the treatment of various diseases is gaining more attention in experimental and clinical studies for the management and/or treatment of various diseases. In this review, the effects of DM on male reproductive system at pre-testicular, testicular and post-testicular levels are discussed. The role of various natural products including whole plant extracts and some pure compounds isolated from plants, with their suggested mechanism of actions is also reviewed.

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Insulin dependant diabetes mellitus: implications for male reproductive function

Abstract: Diabetes is associated with increased sperm nuclear and mtDNA damage that may impair the reproductive capability of these men.

Cited by 440 publications

References 89 publications

Germ cell abnormalities in streptozotocin induced diabetic mice do not correlate with blood glucose level

Germ cell abnormalities in streptozotocin induced diabetic mice do not correlate with blood glucose level

Male Infertility; Evidences, Risk Factors, Causes, Diagnosis and Management in Human

Diabetes mellitus-induced male reproductive impairment: The role of natural products: A review

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