Insulin Resistance Increases the Risk of Spontaneous Abortion after Assisted Reproduction Technology Treatment

Tian, Li; Shen, Huan; Lü, Qun; Norman, Robert J.; Wang, Jim

doi:10.1210/jc.2006-1123

Cited by 126 publications

(90 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We speculated that such an association was at least in part because of common risk factors or shared pathological mechanisms of spontaneous abortion and GDM. For instance, in a cohort study (Tian, 2007) of Chinese women undergoing infertility treatment, insulin resistance, which was a key component of the pathogenesis of GDM, was a strong independent risk factor of spontaneous abortion [20]. The underlying biological mechanisms for such an association, however, are still unclear and warrant further investigations.…”

Section: Discussionmentioning

confidence: 99%

Risk factors of gestational diabetes mellitus in Wuhan city of China--a case control study

Liu¹,

Dai²,

Yang³

et al. 2017

J Pregnancy Reprod

View full text Add to dashboard Cite

Objective: To explore the main risk factors of gestational diabetes mellitus in Wuhan, China.Methods: 206 women with gestational diabetes mellitus who were diagnosed in Hubei Maternal and Child Health Hospital between January 2014 and December 2015 were selected as case group. Meanwhile, 286 healthy pregnant women, who were delivered at the same time, were selected as control group. Maternal age, occupation, race/ethnicity, gestation status, and family history, etc. were obtained from the face-to-face interviews as well as their medical records. Univariate logistic regression analysis and multivariate logistic regression analysis were conducted to explore the risk factors. Results:The factors included into multivariate logistic regression model were maternal age, menarche age, history of menstrual cycle disorder, spontaneous abortion frequency, maternal history of diabetes, and paternal history of diabetes. The Odds Ratios (95%CI) were 1.50 (1.14～2.04), 0. 36 (0.16～0.84), 3.85 (1. 59～9. 36), 3.00 (1.56～5.77), 3.89 (1.15～13.17) and 6.54 (2.42～17.69), respectively. Conclusion:The risk factors of gestational diabetes mellitus were advanced maternal age, history of menstrual cycle disorder, spontaneous abortion frequency, maternal history of diabetes, and paternal history of diabetes, while advanced menarche age was a protective factor for gestational diabetes mellitus.

show abstract

Section: Discussionmentioning

confidence: 99%

Risk factors of gestational diabetes mellitus in Wuhan city of China--a case control study

Liu¹,

Dai²,

Yang³

et al. 2017

J Pregnancy Reprod

View full text Add to dashboard Cite

show abstract

“…Some authors have argued that insulin resistance is a key factor in explaining the association between obesity, PCOS and recurrent miscarriages. 56 Moreover, evidence has shown a possible association between insulin resistance, hyperhomocysteinaemia and the risk of PCOS. 57 Recent studies have highlighted the presence of hypofibronolysis associated with high levels of PAI-1 as being a potential cause of RPL in women with PCOS.…”

Section: Polycystic Ovary Syndromementioning

confidence: 99%

Hormonal causes of recurrent pregnancy loss (RPL)

Pluchino¹,

Drakopoulos²,

Wenger³

et al. 2014

View full text Add to dashboard Cite

Endocrine disorders play a major role in approximately 8% to 12% of recurrent pregnancy loss (rPL). Indeed, the local hormonal milieu is crucial in both embryo attachment and early pregnancy. Endocrine abnormalities, including thyroid disorders, luteal phase defects, polycystic ovary syndrome, hyperprolactinaemia and diabetes have to be evaluated in any case of rPL. Moreover, elevated androgen levels and some endocrinological aspects of endometriosis are also factors contributing to rPL. In the present article, we review the significance of endocrine disease on rPL.

show abstract

“…Women who are obese or overweight (BMI $25 kg/m 2 ) have been shown to be significantly more likely to miscarry chromosomally normal embryos than women with BMI ,25 kg/m 2 , 52,53 which suggests that alternative factors predispose this population to early pregnancy loss. Insulin resistance has been described as an independent risk factor for spontaneous miscarriage, 54 and insulin-sensitizing agents such as metformin have been shown to reduce miscarriage rates. 55 …”

Section: Early Offspring Outcomes: In Utero Miscarriagementioning

confidence: 99%

Effects of maternal obesity on early and long-term outcomes for offspring

Stirrat¹,

Reynolds²

2014

RRN

View full text Add to dashboard Cite

Abstract:The prevalence of maternal obesity has increased significantly in recent years, and obesity is currently the most common comorbidity of pregnancy. Pregnancies of obese women are often defined as "high-risk" for the purposes of clinical care, with many well documented risks to the mother and developing baby. Maternal physiology and metabolism is dysregulated in the context of obesity, which may contribute to some of the adverse outcomes during pregnancy. Furthermore, maternal obesity has been hypothesized to cause harmful effects for the developing baby through "early life programming." This review will examine evidence from human studies for outcomes of offspring from obese women during pregnancy, during labor, during the neonatal period, and later in life.

show abstract

Insulin Resistance Increases the Risk of Spontaneous Abortion after Assisted Reproduction Technology Treatment

Cited by 126 publications

References 18 publications

Risk factors of gestational diabetes mellitus in Wuhan city of China--a case control study

Risk factors of gestational diabetes mellitus in Wuhan city of China--a case control study

Hormonal causes of recurrent pregnancy loss (RPL)

Effects of maternal obesity on early and long-term outcomes for offspring

Contact Info

Product

Resources

About