Insulin stimulation of water intake in humans

Vijande, M.; López-Sela, P.; Brime, J.I.; Bernardo, Rachel; Díaz, Francisco J.; Costales, M.; Marín, B

doi:10.1016/0195-6663(90)90041-6

Cited by 4 publications

(4 citation statements)

References 13 publications

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“…It has been observed that plasma glucose decreased significantly in individuals after treatment with Insulin and the time of the maximum decrease (30 min) was synchronized with the beginning of water intake. [6] Hence there is a strong relationship between water and the function of Insulin that is yet to be understood at a molecular level. These two chains are inter-connected though two disulphide bridges formed between A7-B7 and A20-B19.…”

Section: Introductionmentioning

confidence: 99%

“…It has been observed that plasma glucose decreased significantly in individuals after treatment with Insulin and the time of the maximum decrease (30 min) was synchronized with the beginning of water intake. [6] Hence there is a strong relationship between water and the function of Insulin that is yet to be understood at a molecular level. Despite extensive structural studies that have been done on Insulin, [7][8][9][10] relatively little research have been focused on the molecular dynamics of water molecules around this protein or on dynamics of this protein in water.…”

Section: Introductionmentioning

confidence: 99%

“…It is a known fact that water intake can significantly stimulate the function and dynamics of insulin. It has been observed that plasma glucose decreased significantly in individuals after treatment with insulin and the time of the maximum decrease (30 min) was synchronized with the beginning of water intake . Hence, there is a strong relationship between water and the function of insulin that is yet to be understood at a molecular level.…”

Section: Introductionmentioning

confidence: 99%

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Sensitivity of Water Dynamics to Biologically Significant Surfaces of Monomeric Insulin: Role of Topology and Electrostatic Interactions

Bagchi¹,

Roy

2014

J. Phys. Chem. B

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In addition to the biologically active monomer of the protein insulin circulating in human blood, the molecule also exists in dimeric and hexameric forms that are used as storage. The insulin monomer contains two distinct surfaces, namely, the dimer forming surface (DFS) and the hexamer forming surface (HFS), that are specifically designed to facilitate the formation of the dimer and the hexamer, respectively. In order to characterize the structural and dynamical behavior of interfacial water molecules near these two surfaces (DFS and HFS), we performed atomistic molecular dynamics simulations of insulin with explicit water. Dynamical characterization reveals that the structural relaxation of the hydrogen bonds formed between the residues of DFS and the interfacial water molecules is faster than those formed between water and that of the HFS. Furthermore, the residence times of water molecules in the protein hydration layer for both the DFS and HFS are found to be significantly higher than those for some of the other proteins studied so far, such as HP-36 and lysozyme. In particular, we find that more structured water molecules, with higher residence times (∼ 300-500 ps), are present near HFS than those near DFS. A significant slowing down is observed in the decay of associated rotational auto time correlation functions of O-H bond vector of water in the vicinity of HFS. The surface topography and the arrangement of amino acid residues work together to organize the water molecules in the hydration layer in order to provide them with a preferred orientation. HFS having a large polar solvent accessible surface area and a convex extensive nonpolar region, drives the surrounding water molecules to acquire predominantly an outward H-atoms directed, clathrate-like structure. In contrast, near the DFS, the surrounding water molecules acquire an inward H-atoms directed orientation owing to the flat curvature of hydrophobic surface and the interrupted hydrophilic residual alignment. We have followed escape trajectory of several such quasi-bound water molecules from both the surfaces that reveal the significant differences between the two hydration layers.

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Section: Introductionmentioning

confidence: 99%

“…It has been observed that plasma glucose decreased significantly in individuals after treatment with Insulin and the time of the maximum decrease (30 min) was synchronized with the beginning of water intake. [6] Hence there is a strong relationship between water and the function of Insulin that is yet to be understood at a molecular level. Despite extensive structural studies that have been done on Insulin, [7][8][9][10] relatively little research have been focused on the molecular dynamics of water molecules around this protein or on dynamics of this protein in water.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sensitivity of Water Dynamics to Biologically Significant Surfaces of Monomeric Insulin: Role of Topology and Electrostatic Interactions

Bagchi¹,

Roy

2014

J. Phys. Chem. B

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“…Notably, the previous studies reported that insulin, an important hormone in the control of sugar levels in the body, stimulated water intake in human [32], and intake of sucrose affected thirst responses [28], suggesting that over intake of sugar and abnormal metabolism of this carbohydrate in the body may influence thirst and drinking behavior. However, it is unknown whether over consumption of sweeten food and beverages during pregnancy may have effects on the development of dipsogenic behavior.…”

Section: Introductionmentioning

confidence: 99%

Altered dipsogenic responses and expression of angiotensin receptors in the offspring exposed to prenatal high sucrose

Mao

Liu

et al. 2011

Peptides

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The present study determined water and salt intake as well as expression of AT1 and AT2 receptors in the brain and kidney in the adult offspring rats prenatally exposed to high sucrose. Following the exposure during pregnancy, water intake and salt intake at baseline levels were not changed in the adult offspring. However, after 24 hour water deprivation, consumption of water and salt was significantly increased compared to that of the control. Plasma sodium and osmolality levels remained the same between the offspring in the control and the exposed groups, while hematocrit was higher in the offspring exposed to prenatal high sucrose immediately following water deprivation. Density of renal AT1 receptor protein was the same between the control and the exposed group, while AT2 receptor protein in the kidney was significantly increased in the offspring exposed to prenatal high sucrose in association of thicker basal membrane of glomerular. In the forebrain, both AT1 and AT2 receptor levels were significantly increased in the offspring with history of prenatal high sucrose. In addition, water deprivation induced more c-fos expression in the central dipsogenic areas, including the paraventricular and supraoptic nuclei in the offspring exposed to prenatal high sucrose. The results suggested that prenatal high intake of sucrose may affect development of pathways in regulation of dipsogenic behavior in face of dehydration, which was associated with altered expression of AT1 or/and AT2 receptors in the kidney and brain.

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