Insulinotropic Activity of Standardized Methanolic Extracts of <i>Ficus deltoidea</i> from Seven Varieties

Yahaya, Nurshieren; Dom, Nur Sumirah Mohd; Adam, Zainah; Hamid, Muhajir

doi:10.1155/2018/3769874

Cited by 10 publications

(7 citation statements)

References 26 publications

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“…Additionally, FD stimulates insulin secretion due to its content of water-soluble insulin-secreting compounds and its involvement in the K + -ATP-dependent pathway. These insulinotropic actions of FD differ according to the extract's contents of the antidiabetic compounds (61) .…”

Section: Discussionmentioning

confidence: 99%

Ficus deltoideaextract down-regulates protein tyrosine phosphatase 1B expression in a rat model of type 2 diabetes mellitus: a new insight into its antidiabetic mechanism

et al. 2020

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Ficus deltoidea var. deltoidea Jack (FD) is a well-known plant used in Malay folklore medicine to lower blood glucose in diabetic patients. For further research of the antihyperglycemic mechanisms, the protein tyrosine phosphatase 1B (PTP1B)-inhibitory effect of FD was analysed both in vitro and in vivo. To optimise a method for FD extraction, water, 50, 70, 80, 90 and 95 % ethanol extracts were prepared and determined for their total phenolic and triterpene contents, and PTP1B-inhibition capacity. Among the tested extracts, 70 % ethanol FD extract showed a significant PTP1B inhibition (92·0 % inhibition at 200 µg/ml) and high phenolic and triterpene contents. A bioassay-guided fractionation of the 70 % ethanol extract led to the isolation of a new triterpene (3β,11β-dihydroxyolean-12-en-23-oic acid; F3) along with six known compounds. In vivo, 4 weeks’ administration of 70 % ethanol FD extract (125, 250 and 500 mg/kg/d) to streptozotocin–nicotinamide-induced type 2 diabetic rats reversed the abnormal changes of blood glucose, insulin, total Hb, GLUT2, lipid profile, and oxidative stress in liver and pancreas. Moreover, FD reduced the mRNA expression of the key gluconeogenic enzymes (phosphoenolpyruvate carboxykinase and glucose 6-phosphatase) and restored insulin receptor and GLUT2 encoding gene (Slc2a2) expression. In addition, FD significantly down-regulated the hepatic PTP1B gene expression. These results revealed that FD could potentially improve insulin sensitivity, suppress hepatic glucose output and enhance glucose uptake in type 2 diabetes mellitus through down-regulation of PTP1B. Together, our findings give scientific evidence for the traditional use of FD as an antidiabetic agent.

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Section: Discussionmentioning

confidence: 99%

Ficus deltoideaextract down-regulates protein tyrosine phosphatase 1B expression in a rat model of type 2 diabetes mellitus: a new insight into its antidiabetic mechanism

et al. 2020

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“…ns: not significant vs glibenclamide transduction [14]. The compounds of F5 fraction induces its hypoglycemic effect in normoglycemic rats probably by insulin release, such as a traditional antidiabetic plant Ficus deltoidea var.trengganuensis which triggers insulin secretion from pancreatic beta cells[15].…”

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confidence: 99%

Opposite Effects of F1 and F5 Fractions of Total Methanol Leaf-extract of Dialium guineense (Cesalpiniaceae) on Blood Glucose in Rat

Barboza

Sène

Doupa

et al. 2020

JAMPS

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The purpose of this study is to investigate the effects of total methanol leaf-extract of Dialium guineense (Cesalpiniaceae) and its fractions on blood glucose in rat. The fractions of methanol extract were obtained by chromatography Sephadex LH 20 gel, numbered F1 to F5. Experiments were performed in normoglycemic, glucose tolerance test, and type 2 diabetic rats. The total methanol leaf-extract (300 mg/kg, per os), induced a significant increase of blood glucose level in normoglycemic rats (2.27±0.12 vs 0.94±0.03 g/L) (p<0.05, n=5). F1 and F2 fractions (100 mg/kg, per os) increased the blood glucose level. Glycaemia respectively varied from 0.90 ± 0.03 to 2. 28 ± 0.22 g/L and 0.91 ± 0.03 to 1.43 ± 0.04 g /L (p<0.05, n=5). However, F5 fraction (300 mg/kg, per os), induced hypoglycemia (0.61 ± 0.01 vs 0. 80 ± 0.03 g/L) (p<0.05, n=5). F5 fraction prevented the pic of hyperglycemia caused by glucose (4 g/kg, per os). In type 2 diabetic rats, the daily oral administration of F5 fraction (300 mg/kg) induced an anti-hyperglycemic effect (1.28 ± 0.15 vs 4.48 ± 0.08 g/L). Fractionation by gel permeation chromatography allowed to highlight the presence of compounds both hyper-and hypoglycemic in total methanol leaf-extract of D. guineense. The lack of hypoglycemic effect in normoglycemic rats of total methanol leaf-extract, could respectively be related to the presence of both hyper- and hypoglycemic compounds in F1 and F5 fractions, which induced opposite effects.

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“…Plant Name Antidiabetic Activity [46][47][48][49][50] Teucrium polium Increase insulin secretion [51] Tabernaemontana divaricata Increase blood insulin and promote pancreatic β-cells regeneration in mice [52] Gymnema sylvestre Increase insulin and pancreatic β-cells regeneration in rodent [53] Ficus deltoidea Increase insulin secretion [54] Bidens pilosa Increase insulin secretion…”

Section: Referencesmentioning

confidence: 99%

Teucrium polium: Potential Drug Source for Type 2 Diabetes Mellitus

Albadr

Crowe

Caccetta

2022

Biology

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The prevalence of type 2 diabetes mellitus is rising globally and this disease is proposed to be the next pandemic after COVID-19. Although the cause of type 2 diabetes mellitus is unknown, it is believed to involve a complex array of genetic defects that affect metabolic pathways which eventually lead to hyperglycaemia. This hyperglycaemia arises from an inability of the insulin-sensitive cells to sufficiently respond to the secreted insulin, which eventually results in the inadequate secretion of insulin from pancreatic β-cells. Several treatments, utilising a variety of mechanisms, are available for type 2 diabetes mellitus. However, more medications are needed to assist with the optimal management of the different stages of the disease in patients of varying ages with the diverse combinations of other medications co-administered. Throughout modern history, some lead constituents from ancient medicinal plants have been investigated extensively and helped in developing synthetic antidiabetic drugs, such as metformin. Teucrium polium L. (Tp) is a herb that has a folk reputation for its antidiabetic potential. Previous studies indicate that Tp extracts significantly decrease blood glucose levels r and induce insulin secretion from pancreatic β-cells in vitro. Nonetheless, the constituent/s responsible for this action have not yet been elucidated. The effects appear to be, at least in part, attributable to the presence of selected flavonoids (apigenin, quercetin, and rutin). This review aims to examine the reported glucose-lowering effect of the herb, with a keen focus on insulin secretion, specifically related to type 2 diabetes mellitus. An analysis of the contribution of the key constituent flavonoids of Tp extracts will also be discussed.

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Insulinotropic Activity of Standardized Methanolic Extracts of Ficus deltoidea from Seven Varieties

Cited by 10 publications

References 26 publications

Ficus deltoideaextract down-regulates protein tyrosine phosphatase 1B expression in a rat model of type 2 diabetes mellitus: a new insight into its antidiabetic mechanism

Ficus deltoideaextract down-regulates protein tyrosine phosphatase 1B expression in a rat model of type 2 diabetes mellitus: a new insight into its antidiabetic mechanism

Opposite Effects of F1 and F5 Fractions of Total Methanol Leaf-extract of Dialium guineense (Cesalpiniaceae) on Blood Glucose in Rat

Teucrium polium: Potential Drug Source for Type 2 Diabetes Mellitus

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