Intake of trans fatty acid–rich hydrogenated fat during pregnancy and lactation inhibits the hypophagic effect of central insulin in the adult offspring

Albuquerque, Kelse Tibau de; Sardinha, Fátima Lúcia de Carvalho; Telles, Mônica Marques; Watanabe, Regina Lúcia Harumi; Nascimento, Cláudia Maria Oller do; Carmo, Maria G. Tavares do; Ribeiro, Eliane

doi:10.1016/j.nut.2006.04.009

Cited by 55 publications

(39 citation statements)

References 56 publications

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“…There is some evidence that they are inversely related to PUFA in breast milk, which may compromise benefits [Innis and King, 1999]. Combined with experimental data [Albuquerque et al, 2006;Morrison et al, 2008;Pisani et al, 2008aPisani et al, , 2008b, sufficient data exist on TFA to warrant caution against consumption of foods with PHVO in pregnancy and lactation, though the data in humans are largely associational and do not permit setting of quantitative targets.…”

Section: Dietary Fat Intake In Pregnancy and Lactationmentioning

confidence: 99%

Background Paper on Fat and Fatty Acid Requirements during Pregnancy and Lactation

2009

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Section: Dietary Fat Intake In Pregnancy and Lactationmentioning

confidence: 99%

Background Paper on Fat and Fatty Acid Requirements during Pregnancy and Lactation

2009

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“…Impaired insulin-induced hypophagia, as well as impaired hypothalamic insulin signalling, have been shown in adult rats submitted to intrauterine food restriction, in rats fed a trans fatty acid-enriched, and in rats fed a soybean oil-enriched diet (4,25,59). …”

Section: We Did Not Find Any Differences In Hypothalamic Levels Of Irmentioning

confidence: 99%

“…Perturbations in tissue fatty acid composition have been reported in a number of health conditions, such as cardiovascular and metabolic diseases, cancer, neurodegenerative and behavioural disorders (21)(22)(23)(24). These perturbations are manifested mainly by increased saturated, trans and omega 6 fatty acids, and concomitant decreased omega 3 fatty acids (5,(25)(26)(27).…”

Section: Introductionmentioning

confidence: 99%

Deleterious effects of lard-enriched diet on tissues fatty acids composition and hypothalamic insulin actions

Dornellas

Watanabe

Pimentel

et al. 2015

Prostaglandins, Leukotrienes and Essential Fatty Acids

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“…Nutr., Campinas, 22(1):163-171, jan./fev., 2009 Revista de Nutrição obesity, has also been seen in adult male rats whose mothers ate a normocaloric diet rich in trans fatty acids 19 .…”

Section: Interestingly Impairment Of the Hypophagia Induced By Insulmentioning

confidence: 99%

“…By using antiphosphotyrosine as the primary antibody, it is possible to estimate the activation of the initial steps of insulin signaling, i.e., IR and IRSs tyrosine phosphorylation. With this approach, impairment of insulin signaling has been demonstrated in the hypothalamus of obese Zucker rats and of rats undernourished or fed with trans fatty acids intra uterus 9,17,19 .…”

Section: Detecting Brain Proteins: Immunoblot and Proteomicsmentioning

confidence: 99%

Studying the central control of food intake and obesity in rats

Ribeiro

2009

Rev. Nutr.

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A B S T R A C TThe central nervous system regulates energy intake and expenditure through a complex network of neurotransmitters and neuromodulators. It is of great interest to understand the relevance of these systems to the physiological control of energy balance and to the disturbances of obesity. The present paper discusses some of the methods to address this field used at the laboratory of Endocrine Physiology of Universidade Federal de São Paulo. Initially, different experimental models of rat obesity are presented, namely the hypothalamic induced monosodium glutamate model, the Zucker genetic model, and the dietary model. The principles of brain microdialysis are also presented, the technique applied to obtain representative samples of the extracellular fluid of brain sites involved in feeding control. The microdialysate levels of serotonin, an important anorexigenic neurotransmitter, are determined by HPLC with electrochemical detection. The immunoblot technique (Western blot) is used to determine hypothalamic levels of proteins relevant to the anorexigenic effect of serotonin and to analyze the acute activation of the insulin signaling cascade in the hypothalamus. The final section addresses the potential applications of proteomics in the study of the central control of feeding.Indexing terms: Brain microdialysis. Experimental Studies. Food intake. Hypothalamus. Obesity. Rats. R E S U M O

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Intake of trans fatty acid–rich hydrogenated fat during pregnancy and lactation inhibits the hypophagic effect of central insulin in the adult offspring

Cited by 55 publications

References 56 publications

Background Paper on Fat and Fatty Acid Requirements during Pregnancy and Lactation

Background Paper on Fat and Fatty Acid Requirements during Pregnancy and Lactation

Deleterious effects of lard-enriched diet on tissues fatty acids composition and hypothalamic insulin actions

Studying the central control of food intake and obesity in rats

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