Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis

“…In a meta-analysis, intake of vitamin E, almond and other nuts (antioxidants) was inversely associated with the risk of PD (ETMINAN et al, 2005). Vitamin C and β-carotene did not show any protection.…”

Section: Parkinson's Diseasementioning

confidence: 94%

Premature or pathological aging: longevity

Sgarbieri

Pacheco

2017

Braz. J. Food Technol.

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The main objective of this literature review was to summarize and characterize the main factors and events that may negatively influence quality of life and human longevity. The factors that act on premature aging processes are essentially the same as those of natural or healthy aging, but in a more intense and uncontrolled manner. Such factors are: 1) genetic (genome); 2) metabolic (metabolome); 3) environmental (life conditions and style, including diet). Factors 1 and 2 are more difficult to control by individuals; once depending on socioeconomic, cultural and educational conditions. Differently of environmental factors that may be totally controlled by individuals. Unfamiliarity with these factors leads to chronic and/or degenerative diseases that compromise quality of life and longevity.Keywords: Human longevity; Metabolic changes; Aging; Life quality; Diet. ResumoO principal objetivo desta revisão da literatura foi resumir e caracterizar os principais fatores e eventos que podem influenciar negativamente a qualidade de vida e a longevidade humana. Os fatores que atuam nos processos de envelhecimento prematuro são essencialmente os mesmos que aqueles relacionados ao envelhecimento saudável ou natural, mas em uma maior intensidade ou maneira descontrolada. Tais fatores são: 1) genéticos (genoma); 2) metabólicos (metaboloma); 3) ambientais (condições e estilos de vida, incluindo a alimentação). Os fatores dos itens 1 e 2 são mais difíceis de ser controlados, pois dependem das condições socioeconômicas, culturais e educacionais. Diferentemente dos fatores ambientais que podem ser controlados pelo indivíduo. A falta de familiaridade com esses fatores leva a doenças crônicas e/ou degenerativas que comprometem a qualidade de vida e a longevidade. Palavras-chave:Longevidade; Alterações metabólicas; Envelhecimento; Qualidade de vida; Alimentação.

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“…The potential benefits seen are explained to be linked to its chain-breaking capabilities in biological membranes, preventing induced oxidative damage by trapping reactive oxyradicals. Interestingly, a meta-analysis showed a protective effect against PD in humans with both moderate and high intake of vitamin E, the effect being more significant in men [13]. Data for a protective or preventative role of vitamin E appears to be stronger than other vitamins.…”

Section: Neuroprotective Nutrients Vitaminsmentioning

confidence: 99%

“…Previously, vitamin A and β-carotene were shown to inhibit alpha-synuclein fibril formation and destabilize formed fibrils in dose-dependent manner in vitro [12]. Although several human studies failed to identify a link with vitamin A and PD [13], one study reported a protective effect of β-carotene in PD in a Japanese population [14]. In mice, pretreatment with β-carotene partially protected against MPTP-induced neurotoxicity [15,16], but not in primates.Lycopene, another carotenoid compound, reduces oxidative stress and cognitive decline in a rotenone-induced rodent model of PD [17].…”

Section: Neuroprotective Nutrients Vitaminsmentioning

confidence: 99%

“…Interestingly, high doses of vitamin C and E given to early stage PD patients, demonstrated a decrease in disease progression. However, subsequent studies found no significant association between intake of dietary vitamin C or vitamin C supplements and risk of PD [13]. Vitamin C was found to increase dopamine synthesis in human neuroblastoma cell line [20].…”

Section: Neuroprotective Nutrients Vitaminsmentioning

confidence: 99%

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Current Understanding on the Beneficial Role of Nutrition in Parkinson’s Disease –An Overview

Muralidhara¹,

Sv²,

SC³

2017

J Aging Sci

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Various nutritional components belonging to different classes of natural dietary origin display modulatory (protective) properties against age-related neurodegenerative disorders (NDD) such as Parkinson's disease (PD) and Alzheimer's disease. These compounds termed as nutraceuticals which have been shown to act at various biochemical and metabolic levels and exhibit different degree of neuroprotective properties. Present review aims to summarize the current status on the modulatory impact of some of the major nutritional compounds on the pathophysiology of PD, the second most common NDD in humans. Primarily, we have examined the data demonstrated in animal models and postulated through epidemiological studies on the compounds/molecules/life style factors which reduce the risk associated with PD and probable mechanism/s through which they elicit neuroprotection. Further we also included some of the conflicting information about the compounds which may enhance the risk associated with PD. Additionally, emphasis is also given about the new approaches to understand the impact of nutrition on the epigenome in relation to the development of NDD with a short note on emerging ideas relating to nutritional genomics.

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Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis

Cited by 256 publications

References 25 publications

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

Premature or pathological aging: longevity

Current Understanding on the Beneficial Role of Nutrition in Parkinson’s Disease –An Overview

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