This paper firstly divides the enterprise informatization strategy into three objectives, namely cost (C), time (T) and performance (P), so as to form a triangle with mutual constraints and equilibrium. Secondly, based on demand effect curve fitting, establish the product sales revenue effect function to find the product price that maximizes sales revenue. And under the cumulative effect of the multi-period business decision-making scheme, the traditional Markov process model is improved to form a multi-period business decision-making optimization method based on the Markov process. Finally, using Enterprise A as a study case in the horizontal expansion stage, simulation and sensitivity analysis of the enterprise’s business decision-making scheme are performed. The results show that in the 8-year operation cycle, as the target profit margin increases from 0.05 to 0.20, the cumulative profit level decreases from 11.43 to 8.38. Enterprises can select the scheme that obtains the optimal comprehensive ability in one aspect according to their own internal and external environments as the final implementation scheme.