Integrated block copolymer prodrug nanoparticles for combination of tumor oxidative stress amplification and ROS-responsive drug release

Yin, Wei; Ke, Wei; Chen, Weijian; Xi, Longchang; Zhou, Qinghao; Mukerabigwi, Jean Felix; Ge, Zhishen

doi:10.1016/j.biomaterials.2018.12.032

Cited by 175 publications

(108 citation statements)

References 65 publications

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“…The controllably supramolecular nanoassemblies in response to various stimuli, such as light, redox, pH, and temperature, have been explored in drug/gene/protein delivery and tissue engineering applications . A series of materials containing boric acid ester, ferrocene (Fc), thioketal, or peroxalate ester can respond to reactive oxygen species (ROS) microenvironment.…”

Section: Introductionmentioning

confidence: 99%

Oxidation‐Responsive Nanoassemblies for Light‐Enhanced Gene Therapy

Zhang

Wang

et al. 2019

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Microenvironment‐responsive supramolecular assemblies have attracted great interest in the biomedical field due to their potential applications in controlled drug release. In this study, oxidation‐responsive supramolecular polycationic assemblies named CPAs are prepared for nucleic acid delivery via the host–guest interaction of β‐cyclodextrin based polycations and a ferrocene‐functionalized zinc tetraaminophthalocyanine core. The reactive oxygen species (ROS) can accelerate the disassembly of CPA/pDNA complexes, which would facilitate the release of pDNA in the complexes and further benefit the subsequent transfection. Such improvement in transfection efficiency is proved in A549 cells with high H2O2 concentration. Interestingly, the transfection efficiencies mediated by CPAs are also different in the presence or absence of light in various cell lines such as HEK 293 and 4T1. The single oxygen (1O2), produced by photosensitizers in the core of CPAs under light, increases the ROS amount and accelerates the disassembly of CPAs/pDNA complexes. In vitro and in vivo studies further illustrate that suppressor tumor gene p53 delivered by CPAs exhibits great antitumor effects under illumination. This work provides a promising strategy for the design and fabrication of oxidation‐responsive nanoassemblies with light‐enhanced gene transfection performance.

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Section: Introductionmentioning

confidence: 99%

Oxidation‐Responsive Nanoassemblies for Light‐Enhanced Gene Therapy

Zhang

Wang

et al. 2019

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“…In particular, H 2 O 2 enrichment in tumor sites (ca. 1 m m ) makes it a superior stimulus for drug release, and it presents stimuli‐responsive release behavior if the chemotherapeutic drugs are conjugated onto the polymers through H 2 O 2 ‐cleavable thioketal or thioether linkages . On this basis, Liu et al.…”

Section: Stimuli‐responsive Drug‐release Nanosystemsmentioning

confidence: 99%

Strategies To Design and Synthesize Polymer‐Based Stimuli‐Responsive Drug‐Delivery Nanosystems

Qin

2020

ChemBioChem

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The emergence and development of nanomedicine have alleviated problems existing in traditional chemotherapy drugs, such as short lifetime, concomitant side effects, and weak tumor‐targeting capability. Nevertheless, the further applications of drug‐loaded nanocarriers are still limited by their premature leakage, weak targeting capability, and insufficient intracellular release. In past decades, various nanocarriers, including gold nanoparticles, porous silica nanoparticles, carbon‐based nanoparticles, micelles, liposomes, and polymer–drug conjugates, have been intensively investigated for tumor therapy. Among these, polymer‐based nanocarriers have attracted more attention due to their biocompatibilities and capability of being modified for stimuli‐responsive drug release. In this review, three popular strategies to design and synthesize polymer‐based stimuli‐responsive nanocarriers are discussed. The discussion goes from stimuli‐responsive polymers with responsive backbones or modified by responsive functional groups for drug encapsulation and release to polymer–drug conjugates with responsive covalent linkages. In particular, due to the facile synthetic processes and mild reaction conditions for crosslinked structures, the latest progress in responsive crosslinked structures is emphasized. Finally, future perspectives for these nanomaterials are given, which are expected to provide inspiration for researchers to design more effective and safer tumor‐killing nanomedicines.

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“…Russel反应机制催化纳米粒子表面的LAHP分解产生 1 O 2 , 无需外加化疗药物即可有效杀死肿瘤细胞(图 4) [59] . 图 3 Lapa负载的聚前药两亲分子(PEG-b-PTCPT)胶束组装体用于CT和CDT协同治疗 [51] (网络版彩图) 除单独使用外, ION还可以与其他ROS产生剂协同作用. Gao等 [59] 同时将Lapa和ION负载到pH敏感的 [58] (网络版彩图) Figure 4 Schematic illustration of the fabrication of hybrid iron oxide nanoparticles by tethering hydrophobic (p1) and hydrophilic (p2) polymers onto the surface.…”

Section: 细胞的酸性细胞器中释放铁离子铁离子进一步通过unclassified

“…Schematic illustration of the fabrication of β-lapachone-loaded micelles self-assembled from PEG-b-PTCPT diblock copolymer[51] (color online).…”

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confidence: 99%

Fabrication of smart polymeric nanovectors to amplify intracellular oxidative stress for chemodynamic therapy

Hu¹,

Liu²

2020

Sci. Sin.-Chim

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Integrated block copolymer prodrug nanoparticles for combination of tumor oxidative stress amplification and ROS-responsive drug release

Cited by 175 publications

References 65 publications

Oxidation‐Responsive Nanoassemblies for Light‐Enhanced Gene Therapy

Oxidation‐Responsive Nanoassemblies for Light‐Enhanced Gene Therapy

Strategies To Design and Synthesize Polymer‐Based Stimuli‐Responsive Drug‐Delivery Nanosystems

Fabrication of smart polymeric nanovectors to amplify intracellular oxidative stress for chemodynamic therapy

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