Integrated Low Cost Optical Biosensor for High Resolution Sensing of Myeloperoxidase (MPO) Activity Through Carbon Nanotube Degradation

Nandeshwar, Ruchira; Tallur, Siddharth

doi:10.1109/jsen.2020.3020705

Cited by 12 publications

(3 citation statements)

References 66 publications

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“…Early detection and accurate diagnosis of the virus can prevent the spread of coronavirus infection. In addition, diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for tracking the route of transmission and suitable treatment for patients in the event of a pandemic [ 214 , 215 ]. Pinals, R et al introduced an SWCNT-based optical sensing approach toward this end [ 179 ].…”

Section: Applications Of Carbon Nanotubes As Biosensorsmentioning

confidence: 99%

Carbon Nanotube and Its Derived Nanomaterials Based High Performance Biosensing Platform

Mondal

Surwase

et al. 2022

Biosensors

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After the COVID-19 pandemic, the development of an accurate diagnosis and monitoring of diseases became a more important issue. In order to fabricate high-performance and sensitive biosensors, many researchers and scientists have used many kinds of nanomaterials such as metal nanoparticles (NPs), metal oxide NPs, quantum dots (QDs), and carbon nanomaterials including graphene and carbon nanotubes (CNTs). Among them, CNTs have been considered important biosensing channel candidates due to their excellent physical properties such as high electrical conductivity, strong mechanical properties, plasmonic properties, and so on. Thus, in this review, CNT-based biosensing systems are introduced and various sensing approaches such as electrochemical, optical, and electrical methods are reported. Moreover, such biosensing platforms showed excellent sensitivity and high selectivity against not only viruses but also virus DNA structures. So, based on the amazing potential of CNTs-based biosensing systems, healthcare and public health can be significantly improved.

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Section: Applications Of Carbon Nanotubes As Biosensorsmentioning

confidence: 99%

Carbon Nanotube and Its Derived Nanomaterials Based High Performance Biosensing Platform

Mondal

Surwase

et al. 2022

Biosensors

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“…Nandeshwar et al [ 209 ] developed a novel colourimetric technique based upon the degradation of SWCNTs. The enzyme myeloperoxidase is an early warning biomarker for cardiovascular disease.…”

Section: Biosensors Based On Carbon Nanotubesmentioning

confidence: 99%

Carbon Nanotube (CNT)-Based Biosensors

2021

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This review focuses on recent advances in the application of carbon nanotubes (CNTs) for the development of sensors and biosensors. The paper discusses various configurations of these devices, including their integration in analytical devices. Carbon nanotube-based sensors have been developed for a broad range of applications including electrochemical sensors for food safety, optical sensors for heavy metal detection, and field-effect devices for virus detection. However, as yet there are only a few examples of carbon nanotube-based sensors that have reached the marketplace. Challenges still hamper the real-world application of carbon nanotube-based sensors, primarily, the integration of carbon nanotube sensing elements into analytical devices and fabrication on an industrial scale.

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“…These sensors are advantageous compared to the immunoassay as they allow the detection of active MPO. Similarly, Ruchira et al developed an optical sensor to detect MPO by quantifying the degradation of carbon nanotubes induced by the oxidizing activity of this enzyme [ 20 ]. However, all these sensor approaches require complex protocols for sample preparation, and specialized electronic devices or supporting reagents, limiting their wider use.…”

Section: Introductionmentioning

confidence: 99%

Rapid Colorimetric Detection of Wound Infection with a Fluidic Paper Device

Hoyo

Bassegoda

Ferreres

et al. 2022

IJMS

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Current procedures for the assessment of chronic wound infection are time-consuming and require complex instruments and trained personnel. The incidence of chronic wounds worldwide, and the associated economic burden, urge for simple and cheap point-of-care testing (PoCT) devices for fast on-site diagnosis to enable appropriate early treatment. The enzyme myeloperoxidase (MPO), whose activity in infected wounds is about ten times higher than in non-infected wounds, appears to be a suitable biomarker for wound infection diagnosis. Herein, we develop a single-component foldable paper-based device for the detection of MPO in wound fluids. The analyte detection is achieved in two steps: (i) selective immunocapture of MPO, and (ii) reaction of a specific dye with the captured MPO, yielding a purple color with increasing intensity as a function of the MPO activity in infected wounds in the range of 20–85 U/mL. Ex vivo experiments with wound fluids validated the analytic efficiency of the paper-based device, and the results strongly correlate with a spectrophotometric assay.

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Integrated Low Cost Optical Biosensor for High Resolution Sensing of Myeloperoxidase (MPO) Activity Through Carbon Nanotube Degradation

Cited by 12 publications

References 66 publications

Carbon Nanotube and Its Derived Nanomaterials Based High Performance Biosensing Platform

Carbon Nanotube and Its Derived Nanomaterials Based High Performance Biosensing Platform

Carbon Nanotube (CNT)-Based Biosensors

Rapid Colorimetric Detection of Wound Infection with a Fluidic Paper Device

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