Integrated Multiprocess Microfluidic Systems for Automating Analysis

Abstract

M icrofluidic technologies have been applied extensively in rapid sample analysis. Some current challenges for standard microfluidic systems are relatively high detection limits, and reduced resolving power and peak capacity compared with conventional approaches. The integration of multiple functions and components onto a single platform can overcome these separation and detection limitations of microfluidics. Multiplexed systems can greatly increase peak capacity in multidimensional separations and can increase sample throughput by analyzing many samples simultaneously. On-chip sample preparation, including labeling, preconcentration, cleanup, and amplification, can all serve to speed up and automate processes in integrated microfluidic systems. This article summarizes advances in integrated multiprocess microfluidic systems for automated analysis, their benefits, and areas for needed improvement.

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